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How bio-inspired materials might inform the design of next-generation computers

Ralph Lydic, professor in the UT Department of Psychology, and Dmitry Bolmatov, a research assistant professor in the UT Department of Physics and Astronomy, are part of a UT/ORNL research team studying how bio-inspired materials might inform the design of next-generation computers. Their results, published recently in the Proceedings of the National Academy of Sciences, could have big implications for both edge computing and human health.

Scientists at ORNL and UT discovered an artificial is capable of long-term potentiation, or LTP, a hallmark of biological learning and memory. This is the first evidence that a cell alone—without proteins or other biomolecules embedded within it—is capable of LTP that persists for many hours. It is also the first identified nanoscale structure in which memory can be encoded.

“When facilities were shut down as a result of COVID, this led us to pivot away from our usual membrane research,” said John Katsaras, a biophysicist in ORNL’s Neutron Sciences Directorate specializing in neutron scattering and the study of biological membranes at ORNL. “Together with postdoc Haden Scott, we decided to revisit a system previously studied by Pat Collier and co-workers, this time with an entirely different electrical stimulation protocol that we termed ‘training.’”.

Variety of healthy eating patterns linked with lower risk of premature death

A variety of healthy eating patterns are linked to reduced risk of premature death, according to a new study led by Harvard T.H. Chan School of Public Health researchers. They found that participants who scored high on adherence to at least one of four healthy eating patterns were less likely to die during the study period from any cause and less likely to die from cardiovascular disease, cancer, or respiratory disease, compared with people with lower scores. The findings are consistent with the current Dietary Guidelines for America, which recommend multiple healthy eating patterns.

“The Dietary Guidelines for Americans are intended to provide science-based dietary advice that promotes and reduces major chronic diseases. Thus, it is critical to examine the associations between DGAs-recommended dietary patterns and long-term outcomes, especially mortality,” said corresponding author Frank Hu, Fredrick J. Stare Professor of Nutrition and Epidemiology and chair of the Department of Nutrition.

The study will be published online January 9, 2023, in JAMA Internal Medicine.

Dr. Richard Burt MD — Pioneering Hematopoietic Stem Cell Transplants (HSCT) For Autoimmune Disorders

Pioneering Hematopoietic Stem Cell Transplants (HSCT) For Autoimmune Disorders — Dr. Richard K. Burt


Dr. Richard K. Burt MD (https://astemcelljourney.com/about/drrichardburt/) is a Fulbright Scholar, Professor of Medicine at Scripps Health Care, tenured retired Professor of Medicine at Northwestern University where he served as Chief of Immunotherapy and Autoimmune Diseases, and CEO of Genani Biotechnology.

Dr. Burt endeavored for thirty-five years, first with animal models and then with some of the world’s first clinical trials, to bring the field of stem cell and cellular therapy to the patient’s bedside.

Dr. Burt has published more than 145 mostly first author articles and is the Editor of four medical textbooks. He was the first Autoimmune Committee Chairperson for the International Bone Marrow Transplant Registry (IBMTR) and was the principal investigator of a National Institute of Health (NIH) $10,000,000 multi-center contract to develop stem cell clinical trials for autoimmune diseases.

Dr. Burt performed America’s first hematopoietic stem cell transplant (HSCT) for multiple sclerosis (MS), systemic lupus erythematosus (SLE), Crohn’s disease (CD), stiff person syndrome (SPS), and chronic inflammatory demyelinating polyneuropathy (CIDP) and published the world’s first randomized clinical stem cell transplantation trials for systemic sclerosis and multiple sclerosis.

Researchers discover exploiting microbiome bacteria in patients with lung infections improves low oxygen levels

Newspaper headlines from the U.S. to the U.K. and most places in between highlight the surge in sick patients suffering from respiratory viruses. The so-called “tripledemic” of lung infections including respiratory synclinal virus (RSV), influenza (flu) and COVID-19 (coronavirus) is likely to last throughout the winter season. This explosion of infections requires more treatment options to support overloaded hospitals and overworked medics as they restore people’s health.

It has been known for a long time that intubation of an infant with any , or even an adult with severe COVID-19 using either ventilation or extra-corporeal membrane oxygenation (ECMO), comes with risks and that could cause permanent damage not limited to the lungs. However, hypoxia, which means , is a that is a common complication of severe . If not treated, it can lead to severe disability and even death.

A New Weapon Against Antibiotic-Resistant Bacteria

UNIGE researchers have discovered that a medication commonly used to treat herpes can combat an antibiotic-resistant bacterium by disrupting its defense mechanisms.

Antibiotic resistance, or the ability of bacteria to develop resistance to treatment with antibiotics, has become a major concern for global health. The World Health Organization (WHO) considers it one of the greatest threats to health. The overuse of antibiotics has contributed to the emergence of antibiotic-resistant bacteria, which can cause serious illness and death. One example of an antibiotic-resistant pathogen is Klebsiella pneumoniae, a bacterium commonly found in hospitals and known for its virulence. Without effective treatment options, we could see a resurgence of diseases such as pneumonia and salmonella, which were once easily treated with antibiotics.

Researchers at the University of Geneva (UNIGE) have found that edoxudine, an anti-herpes molecule developed in the 1960s, can disrupt the protective surface of Klebsiella bacteria and make them more vulnerable to being eliminated by immune cells. The researchers’ findings were recently published in the journal PLOS ONE.

Consumer Health: Do you know the symptoms of glaucoma?

January is National Glaucoma Awareness Month, which makes this a good time to learn more about treating this group of eye conditions.

About 3 million people in the U.S. have glaucoma, and it’s the second-leading cause of blindness worldwide, according to the Centers for Disease Control and Prevention.

Glaucoma is a group of eye conditions that damage the optic nerve, often due to abnormally high pressure in your eye. Elevated eye pressure is due to a buildup of the fluid that flows throughout the inside of your eye. When this fluid is overproduced or the drainage system doesn’t work properly, the fluid can’t flow out at its normal rate and eye pressure increases.

New Alzheimer’s Drug Approved by FDA, Promises to Slow Disease

U.S. health regulators gave early approval to a new Alzheimer’s drug from Eisai Co. and Biogen Inc., the most promising to date in a new class of medicines that may help slow cognitive decline caused by the disease.

The Food and Drug Administration granted conditional approval to the drug, called lecanemab, based on an early study finding it reduced levels of a sticky protein called amyloid from the brains of people with early-stage Alzheimer’s. The companies will sell it under the brand name Leqembi.

Geometry of brain, dimensions of mind: Researchers identify new ways to characterize states of consciousness

What it means to be conscious is more than just a philosophical question. Researchers continue to investigate how conscious experience arises from the electrochemical activity of the human brain. The answer has important implications for the way brain health is understood—from coma, wherein a person is alive but unable to move or respond to his or her environment, to surgical anesthesia, to the altered thought processes of schizophrenia.

Recent research suggests that there’s no one location in the brain that causes consciousness, pointing to a network phenomenon. However, tracing the various linkages between regions in the brain networks that give rise to awareness and wakefulness has been elusive.

A new approach using functional MRI, an imaging technique that allows you to see and measure brain activity through changes in blood flow over time, provides new insight into how we describe and study conscious states.

Intense exercise encourages coronary artery calcification

Exercise and physical activity reduce the risk of cardiovascular disease (CVD). It has been observed that an active individual is at a 30% to 40% lower risk of CVD. However, previous cross-sectional studies have failed to determine whether exercise has a significant impact on expediting coronary atherosclerosis and plaque morphology. A recent Circulation journal paper has focused on investigating the relationship between exercise volume and intensity and the progression of coronary atherosclerosis in middle-aged and older male athletes.

Study: Exercise Volume Versus Intensity and the Progression of Coronary Atherosclerosis in Middle-Aged and Older Athletes: Findings From the MARC-2 Study. Image Credit: sciencepics / Shutterstock.

Dr. Stuart Minchin, Ph.D. — Sustainable Pacific Development Through Science, Knowledge & Innovation

Is the Director General of the Pacific Community (SPC — https://www.spc.int/about-us/director-general) which is the largest intergovernmental organization in the Pacific and serves as a science and technology for development organization owned by the 26 Member countries and territories in the Pacific region.

SPC’s 650 member staff deliver services and scientific advice to the Pacific across the domains of Oceans, Islands and People, and has deep expertise in food security, water resources, fisheries, disasters, energy, maritime, health, statistics, education, human rights, social development and natural resources.

Dr. Minchin previously served as the Chief of the Environmental Geoscience Division of Geoscience Australia, and has an extensive background in the management and modelling of environmental data and the online delivery of data, modelling and reporting tools for improved natural resource management. He has a long track record of conceiving, developing and delivering transformational and innovative projects in the Environmental and Natural Resource Management domains.

Dr. Minchin has represented Australia in key international forums and was Australia’s Principal Delegate to both the UN Global Geospatial Information Management Group of Experts (UNGGIM) and the Intergovernmental Group on Earth Observations (GEO).

Dr. Minchin has previously been responsible for the Environmental Observation and Landscape Science (EOLS) research program in CSIRO and prior to that was a Principal Scientist with the Victorian Department of Sustainability and Environment.

Dr. Minchin has a PhD in Aquatic/Environmental Chemistry, from Monash University, where he also did his undergraduate work in Chemistry achieving a BSc (Hons). He also holds a BSc (Aquatic Science), Aquatic Chemistry and Aquatic Biology from Deakin University.

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