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Australian researchers have uncovered a new form of antimicrobial resistance (AMR), undetectable using traditional laboratory testing methods, in a discovery set to challenge existing efforts to monitor and tackle one of the world’s greatest health threats.

AMR is expected to claim 10 million lives a year by 2050, with scientists racing to understand and get ahead of the diminishing benefits of antibiotics.

Now, a team led by Dr. Timothy Barnett, Head of the Strep A Pathogenesis and Diagnostics team at the Wesfarmers Centre of Vaccines and Infectious Diseases, based at Telethon Kids Institute in Perth, Western Australia, has unearthed a critical clue to the way some bacteria are managing to dodge antibiotics—a finding expected to be the tip of the iceberg.

If you enjoyed this video, you might like my book: https://ageless.link/

I saw a Twitter thread about Bryan Johnson’s ‘Blueprint’, claiming that he’d made himself biologically younger with a highly optimised combination of diet, supplements and exercise. What could that mean? And should we all start chugging 25 pills a day to start on the Blueprint ourselves? Probably not…but the biology behind it is surprisingly interesting.

*Chapters*

00:00 A tweet goes viral.
00:44 Getting ‘biologically younger’
01:23 NAD levels.
03:09 Maximum heart rate.
04:12 Epigenetic clocks.
07:12 Step 1: the Blueprint diet.
09:23 Step 2: ALL THE SUPPLEMENTS
11:43 Step 3: track progress.
12:40 Conclusion.

*Sources and further reading*

My book, Ageless: The new science of getting older without getting old, goes into far more depth about rapamycin, metformin and epigenetic clocks, and lots more! https://ageless.link/

Colon cancer is the second deadliest cancer in the US. Early detection is important but finding and diagnosing polyps is difficult. 2 AI-powered endoscopes have been developed in Japan to tackle the problem. One can judge a lesion’s malignancy in 0.4 second with almost 100% accuracy. The other indicates lesions during an exam, even indistinct ones, like a car navigation system. We also introduce fermented Japanese foods that are beneficial for gut health and explain how they should be eaten.

Year 2021 face_with_colon_three


While the Apple Watch has evolved from a fashionable phone accessory to a high-tech health monitor—capable of scanning for heart conditions and calling for help after injuries—future generations may tap into a deeper set of features to track the body’s inner workings.

This could include long-rumored blood sugar readings, from the wrist-worn gadget, plus blood pressure measurements, hydration levels and more, following newly divulged arrangements with the sensor maker Rockley Photonics.

As first reported by The Daily Telegraph, Rockley now lists Apple as its biggest customer and contributor of the lion’s share—or potentially nearly all—of its revenues dating back to 2019.

The technology, which was created by Barcelona-based researchers at the Centre for Genomic Regulation (CRG) and the Institute for Research in Biomedicine (IRB Barcelona), combines high-resolution microscopy with sophisticated computer modeling. It is the most comprehensive technique to date for studying the shape of genes.

The new technique allows researchers to create and digitally navigate three-dimensional models of genes, seeing not just their architecture but also information on how they move or how flexible they are. Understanding how genes function might help us better understand how they influence the human body in both health and disease since almost every human disease has some genetic basis.

Scientists at University of Florida (UF) Scripps Biomedical Research have developed a potential medicine for a leading cause of ALS and dementia that works by eliminating disease-causing segments of RNA. The compound restored the health of neurons in the lab and rescued mice with the disease.

The potential medication is described this week in the scientific journal Proceedings of the National Academy of Sciences. It is designed to be taken as a pill or an injection, said the lead inventor, professor Matthew Disney, Ph.D., chair of the UF Scripps chemistry department. Importantly, experiments showed that the compound is small enough to cross the blood-brain barrier, a hurdle other approaches have failed to clear, he said.

Amyotrophic lateral sclerosis, or ALS, progressively destroys neurons that control muscles, leading to worsening muscle loss and eventually death. The mutation, a leading cause of inherited ALS, is referred to as “C9 open reading frame 72,” or C9orf72. This mutation also leads to one form of frontotemporal dementia, a brain disease that causes the brain’s frontal and to shrink, resulting in changes in personality, behavior and speech, ultimately resulting in death.

In space — Recent (China Manned Space Agency — No access Chinese mainland) 1. Various of Shenzhou-14 astronaut Cai Xuzhe unpacking packages 2. Various of Shenzhou-14 crew checking facilities, opening boxes and inspecting equipment 3. Shenzhou-14 crew installing and trying out microgravity resistance exercise device 4. Shenzhou-14 astronaut Liu Yang exercising with microgravity resistance exercise device.

The Shenzhou-14 astronauts have completed several missions over the last two weeks, including the installation of equipment in the work area of the Mengtian lab module which they entered for the first time on Nov. 3. Among the scientific and basic living equipment, the astronauts have also set up a small home gym to help them stay fit. The crew members-Chen Dong, Liu Yang and Cai Xuzhe can now keep fit in the lab with a special microgravity resistance exercise device similar to a rowing machine with which astronauts can do squats, heel lifts, hard pulls, rowing and shoulder exercise. Resistance exercise is especially important for astronauts living in zero gravity conditions which can rapidly reduce muscle mass and bone density.

On Sunday, the trio entered the Tianzhou-5 cargo craft to fetch supplies for the Tiangong space station.

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Cancer; The Integrative Perspective — Documentary Film.

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Researchers at Karolinska Institutet in Sweden have identified the bacteria most commonly found in severe oral infections. Few such studies have been done before, and the team now hopes that the study can provide deeper insight into the association between oral bacteria and other diseases. The study is published in Microbiology Spectrum.

Previous studies have demonstrated clear links between and , such as cancer, , diabetes and Alzheimer’s disease. However, there have been few identifying which occur in infected oral-and maxillofacial regions. Researchers at Karolinska Institutet have now analyzed samples collected between 2010 and 2020 at the Karolinska University Hospital in Sweden from patients with severe oral infections and produced a list of the most common bacteria.

This was a collaborative study that was performed by Professor Margaret Sällberg Chen and adjunct Professor Volkan Özenci’s research groups.