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Category: health – Page 173

Challenges in Producing and Analyzing Organoids

Recent advancements in our comprehension of human health and disease have been propelled by pioneering research utilizing in vitro 3D cell culture models, including both single-cell spheroids and multicellular organoids.

The refinement of these 3D cell culture models hinges on the capacity to visualize, measure, and track their development and expansion over time. Nonetheless, the methods employed to evaluate and scrutinize these intricate cell models are not without their challenges.

This video explores the challenges associated with characterizing organoids and introduces some solutions to these challenges.

Learn more about our solutions: https://www.sartorius.com/en/applicat…

Follow us on LinkedIn: / incucyte-live-cell-analysis-systems.

#organoids #3dcells #cellculture #3dcellculture #drugdiscovery

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New study provides genomic insights into kidney cancer risk

MEDIA ADVISORY: An international team of researchers, led by NCI scientists, has identified 50 new areas across the human genome that are associated with the risk of developing kidney cancer.

In a new analysis of genetic susceptibility to kidney cancer, an international team of researchers has identified 50 new areas across the genome that are associated with the risk of developing kidney cancer. These insights could one day be used to advance our understanding of the molecular basis of kidney cancer, inform screening efforts for those at highest risk, and identify new drug targets. The study was led by scientists at the National Cancer Institute (NCI), part of the National Institutes of Health (NIH).

A previous genome-wide association study (GWAS) of people of European ancestry identified 13 regions of the genome that are associated with kidney cancer risk. However, the study population was not diverse. To identify additional regions, researchers conducted a GWAS in participants of many different genetic ancestries that included 29,020 people with kidney cancer and 835,670 people without kidney cancer. Analysis of the data, which came from published studies, biobanks, and a new study, resulted in the identification of 50 new regions associated with the risk of developing kidney cancer, bringing the total number of such regions to 63.

Among the newly identified genetic variants were several associated with a risk of developing papillary renal cell carcinoma, the second most common subtype of renal cell carcinoma. Another variant, in the VHL gene, was common in individuals of African ancestry and was associated with an estimated three times higher risk of developing clear cell renal cell carcinoma, the most common type of kidney cancer.

In a first, scientists use new tech to see inside cancer cells

Technology views living cancer cell:

This technique could provide valuable insights into how different types of cancer respond to treatments. It might also help doctors understand the impact of irradiation on cells, specifically how some cancer cells resist radiation treatment. This resistance may result in relapse of the cancer.

A deeper understanding of cancer biology may lead to the development of more effective treatments in the future.

Moreover, the researchers state that studying lipids inside single cells may help various health areas, including immunity, and infectious diseases.

Combating the Next Pandemic: Experts Call for Global Genetic Warning System

Scientists champion global genomic surveillance using the latest technologies and a ‘One Health’ approach to protect against novel pathogens like avian influenza and antimicrobial resistance, catching epidemics before they start.

The COVID-19 pandemic turned the world upside down. In fighting it, one of our most important weapons was genomic surveillance, based on whole genome sequencing, which collects all the genetic data of a given microorganism. This powerful technology tracked the spread and evolution of the virus, helping to guide public health responses and the development of vaccines and treatments.

But genomic surveillance could do much more to reduce the toll of disease and death worldwide than just protect us from COVID-19. Writing in the journal Frontiers in Science, an international collective of clinical and public health microbiologists from the European Society for Clinical Microbiology and Infectious Diseases (ESCMID) calls for investment in technology, capacity, expertise, and collaboration to put genomic surveillance of pathogens at the forefront of future pandemic preparedness.

UnitedHealth says Change hackers stole health data on ‘substantial proportion of people in America’

The gang, which calls itself RansomHub, published several files on its dark web leak site containing personal information about patients across an array of documents, some of which included internal files related to Change Healthcare. RansomHub said it would sell the stolen data unless Change Healthcare paid a ransom.

In a statement provided to TechCrunch, UnitedHealth spokesperson Tyler Mason confirmed the company paid the cybercriminals. “A ransom was paid as part of the company’s commitment to do all it could to protect patient data from disclosure.” The company would not confirm the amount it paid.

RansomHub is the second gang to demand a ransom from Change Healthcare. The health tech giant reportedly paid $22 million to a Russia-based criminal gang called ALPHV in March, which then disappeared, stiffing the affiliate that carried out the data theft out of their portion of the ransom.

Traditional Japanese Diet associated with Less Brain Shrinkage in Women compared to Western Diet, says research

Cognitive decline and dementia already affect more than 55 million people worldwide. This number is projected to skyrocket over the next few decades as the global population ages.

There are certain risk factors of cognitive decline and dementia that we cannot change – such as having a genetic predisposition to these conditions. But other risk factors we may have more power over – with research showing certain modifiable lifestyle habits, such as smoking, obesity and lack of exercise, are all linked to higher risk of dementia.

What role nutrition plays in preventing cognitive decline and dementia has also been the focus of scientific research for quite some time.

Machine Learning Uncovers New Ways to Kill Bacteria With Non-Antibiotic Drugs

Human history was forever changed with the discovery of antibiotics in 1928. Infectious diseases such as pneumonia, tuberculosis and sepsis were widespread and lethal until penicillin made them treatable.

Surgical procedures that once came with a high risk of infection became safer and more routine. Antibiotics marked a triumphant moment in science that transformed medical practice and saved countless lives.

But antibiotics have an inherent caveat: When overused, bacteria can evolve resistance to these drugs. The World Health Organization estimated that these superbugs caused 1.27 million deaths around the world in 2019 and will likely become an increasing threat to global public health in the coming years.

A National Security Insider Does the Math on the Dangers of AI

Jason Matheny is a delight to speak with, provided you’re up for a lengthy conversation about potential technological and biomedical catastrophe.

Now CEO and president of Rand Corporation, Matheny has built a career out of thinking about such gloomy scenarios. An economist by training with a focus on public health, he dived into the worlds of pharmaceutical development and cultivated meat before turning his attention to national security.

As director of Intelligence Advanced Research Projects Activity, the US intelligence community’s research agency, he pushed for more attention to the dangers of biological weapons and badly designed artificial intelligence. In 2021, Matheny was tapped to be President Biden’s senior adviser on technology and national security issues. And then, in July of last year, he became CEO and president of Rand, the oldest nonprofit think tank in the US, which has shaped government policy on nuclear strategy, the Vietnam War, and the development of the internet.

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