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The study investigated whether electrical therapy, coupled with exercise, would show promise in treating tendon disease or ruptures. It showed that tendon cell function and repair can be controlled through electrical stimulation from an implantable device which is powered by body movement.

Researchers at CÚRAM, the SFI Research Centre for Medical Devices based at NUI Galway, have shown how the simple act of walking can power an implantable stimulator device to speed up treatment of musculoskeletal diseases.

The results of have been published in the prestigious journal Advanced Materials.

Continue reading “Researchers discover way to switch on and speed up tendon healing” »

Trial also will test pausing immunosuppressive medication to improve antibody response.

The National Institutes of Health has begun a clinical trial to assess the antibody response to an extra dose of an authorized or approved COVID-19 vaccine in people with autoimmune disease who did not respond to an original COVID-19 vaccine regimen. The trial also will investigate whether pausing immunosuppressive therapy for autoimmune disease improves the antibody response to an extra dose of a COVID-19 vaccine in this population. The Phase 2 trial is sponsored and funded by the National Institute of Allergy and Infectious Diseases (NIAID), part of NIH, and is being conducted by the NIAID-funded Autoimmunity Centers of Excellence.

“Many people who have an autoimmune disease that requires immunosuppressive therapy have had a poor immune response to the authorized and approved COVID-19 vaccines, placing these individuals at high risk for the disease,” said NIAID Director Anthony S. Fauci, M.D. “We are determined to find ways to elicit a protective immune response to the vaccines in this population. This new study is an important step in that direction.”

Wide Area Networks (WANs), the global backbones and workhorses of today’s internet that connect billions of computers over continents and oceans, are the foundation of modern online services. As COVID-19 has placed a vital reliance on online services, today’s networks are struggling to deliver high bandwidth and availability imposed by emerging workloads related to machine learning, video calls, and health care.

To connect WANs over hundreds of miles, fiber optic cables that transmit data using light are threaded throughout our neighborhoods, made of incredibly thin strands of glass or plastic known as optical fibers. While they’re extremely fast, they’re not always reliable: They can easily break from weather, thunderstorms, accidents, and even animals. These tears can cause severe and expensive damage, resulting in 911 service outages, lost connectivity to the internet, and inability to use smartphone apps.

Continue reading “ARROW, a reconfigurable fiber optics network, aims to take on the end of Moore’s law” »

The global revenue of the pharmaceutical market is 1.2 trillion dollars. With such capital at stake and with the pace of technological disruption, the pharma industry has to embrace new technologies, therapies, and innovations and put a greater focus on prevention and digital health.

In this video, we take a dive into the five trends of how big pharma will adapt to these changing times:

Continue reading “5 Things Big Pharma Can Expect from the 2020s / Episode 13 — The Medical Futurist” »

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Papers referenced in the video:
Human microbiome: an academic update on human body site specific surveillance and its possible role.
https://pubmed.ncbi.nlm.nih.gov/32524177/

Continue reading “Which Gut Bacteria Are Associated With Poor Health, And How Can We Limit Them?” »

Mutations are a part of life. Every time a virus replicates, there is a chance that its genetic code won’t be copied accurately. These typos travel inside new virus particles as they leave one body and move on to infect the next. Some of these mutations die out; others survive and circulate widely. Some mutations are harmless; others increase infectivity or allow a virus to better escape the immune system—that’s when public health bodies might deem that strain a variant of concern.

Swaps or deletions of single amino acids can change the shapes of different proteins. Mutations can happen in any of the proteins of SARS-CoV-2, and these may change the virus’s properties. Many of the worrisome mutations are found on the spike protein, as it is the target of antibody treatments and is mimicked by the currently authorized COVID-19 vaccines. Researchers are especially troubled when typos occur in two parts of the spike protein—the N-terminal domain, which is at the beginning of the protein and which some antibodies target, and the receptor-binding domain (RBD), which grabs hold of ACE2 receptors on human cells and starts the process of infection.

To understand how specific mutations affect the structure and function of the spike protein and what those changes mean for treatments and vaccines, C&EN talked to Priyamvada Acharya, Rory Henderson, and Sophie Gobeil at Duke University. With colleagues, these researchers have combined biochemical assays, cryo-electron microscopy, and modeling to show how the mutations seen in the variants of concern work together to change the stability of the spike protein. The spike is a trimer of three identical protein strands folded and interwoven together. Before the virus has infected a cell, the spike takes on two conformations: a down state, in which the RBD is hidden, and an up state, in which the RBD faces out, ready to bind to ACE2. The team found that different mutations can increase binding in different ways. This process, in which similar features are arrived at independently, is called convergent evolution.

Continue reading “COVID-19: What you need to know about SARS-CoV-2 variants” »

TOKYO, Aug 28 (Reuters) — Two people died after receiving Moderna Inc (MRNA.O) COVID-19 vaccine shots that were among lots later suspended following the discovery of contaminants, Japan’s health ministry said on Saturday.

The men in their 30s died this month within days of receiving their second Moderna doses, the ministry said in a release. Each had a shot from one of three manufacturing lots suspended on Thursday. The causes of death are being investigated.

Ultrasound imaging techniques have proved to be highly valuable tools for diagnosing a variety of health conditions, including peripheral artery disease (PAD). PAD, one of the most common diseases among the elderly, entails the blocking or narrowing of peripheral blood vessels, which limits the supply of blood to specific areas of the body.

Ultrasound imaging methods are among the most popular means of diagnosing PAD, due to their many advantageous characteristics. In fact, unlike other imaging methods, such as computed tomography angiography and magnetic resonance angiography, ultrasound imaging is non-invasive, low-cost and radiation-free.

Most existing ultrasound imaging techniques are designed to capture two-dimensional images in real time. While this can be helpful in some cases, their inability to collect three-dimensional information reduces the reliability of the data they gather, increasing their sensitivity to variations in how individual physicians used a given technique.

Almost a third of working Americans are in some form of medical debt, with nearly a quarter of those with an outstanding balance owing $10,000 or more. Many Americans feel anxious about health care costs and are depleting their own savings to pay the bills, or avoiding going to the doctor due to the cost, and in some cases, as in the case of William Osman, embarking on bizarre projects to highlight the issue.

The YouTuber and engineer, who is known for his bizarre projects that combine engineering and entertainment, posted a video last week outlining how a recent hospital visit requiring X-rays resulted in a staggering $69,210.32 bill.

Continue reading “Engineer Builds His Own X-Ray After Hospital Charges Him $69K” »