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Category: health – Page 139

Is Director of the Division of Research, Innovation and Ventures (DRIVe — https://drive.hhs.gov/) at the Biomedical Advanced Research and Development Authority (https://aspr.hhs.gov/AboutASPR/ProgramOffices/BARDA/Pages/default.aspx), a U.S. Department of Health and Human Services (HHS) office responsible for the procurement and development of medical countermeasures, principally against bioterrorism, including chemical, biological, radiological and nuclear (CBRN) threats, as well as pandemic influenza and emerging diseases.

Dr. Patel is committed to advancing high-impact science, building new products, and launching collaborative programs and initiatives with public and private organizations to advance human health and wellness. As the DRIVe Director, Dr. Patel leads a dynamic team built to tackle complex national health security threats by rapidly developing and deploying innovative technologies and approaches that draw from a broad range of disciplines.

Dr. Patel brings extensive experience in public-private partnerships to DRIVe. Prior to joining the DRIVe team, he served as the HHS Open Innovation Manager. In that role, he focused on advancing innovative policy and funding solutions to complex, long-standing problems in healthcare. During his tenure, he successfully built KidneyX, a public-private partnership to spur development of an artificial kidney, helped design and execute the Advancing American Kidney Health Initiative, designed to catalyze innovation, double the number of organs available for transplant, and shift the paradigm of kidney care to be patient-centric and preventative, and included a Presidential Executive Order signed in July 2019. He also created the largest public-facing open innovation program in the U.S. government with more than 190 competitions and $45 million in awards since 2011.

Prior to his tenure at HHS, Dr. Patel co-founded Omusono Labs, a 3D printing and prototyping services company based in Kampala, Uganda; served as a scientific analyst with Discovery Logic, (a Thomson Reuters company) a provider of systems, data, and analytics for real-time portfolio management; and was a Mirzayan Science and Technology Policy Fellow at The National Academies of Science, Engineering, and Medicine. He also served as a scientist at a nanotechnology startup, Kava Technology.

Continue reading “Dr. Sandeep Patel, Ph.D. — BARDA — Developing Effective Life-Saving Medical Countermeasures For All” | >

Dr. Renee Wegrzyn, Ph.D. is the inaugural director of the Advanced Research Projects Agency for Health (ARPA-H — https://arpa-h.gov/), an agency that supports the development of high-impact research to drive biomedical and health breakthroughs to deliver transformative, sustainable, and equitable health solutions for everyone. ARPA-H’s mission focuses on leveraging research advances for real world impact.

Previously, Dr. Wegrzyn served as a vice president of business development at Ginkgo Bioworks and head of Innovation at Concentric by Ginkgo, where she focused on applying synthetic biology to outpace infectious diseases—including Covid-19—through biomanufacturing, vaccine innovation and biosurveillance of pathogens at scale.

Prior to Ginkgo, Dr. Wegrzyn was program manager in the Biological Technologies Office at DARPA, where she leveraged the tools of synthetic biology and gene editing to enhance biosecurity, promote public health and support the domestic bioeconomy. Her DARPA portfolio included the Living Foundries: 1,000 Molecules, Safe Genes, Preemptive Expression of Protective Alleles and Response Elements and the Detect it with Gene Editing Technologies programs.

Dr. Wegrzyn received the Superior Public Service Medal for her work and contributions at DARPA. Prior to joining DARPA, she led technical teams in private industry in the areas of biosecurity, gene therapies, emerging infectious disease, neuromodulation, synthetic biology, as well as research and development teams commercializing multiplex immunoassays and peptide-based disease diagnostics.

Continue reading “Dr. Renee Wegrzyn, Ph.D. — ARPA-H — Transformative, Sustainable, Equitable Health Solutions For All” | >

What’s next?

Increasingly it seems there is nothing that ChatGPT cannot do, even consulting judges in cases and boosting research. Now, the AI chatbot has been found to score at or around the approximately 60 percent passing threshold for the United States Medical Licensing Exam (USMLE), “with responses that make coherent, internal sense and contain frequent insights.”

This is according to a study published on Thursday in the open-access journal PLOS Digital Health.

AndreyPopov/iStock.

Continue reading “Doctor ChatGPT? AI-bot almost passes the US Medical Licensing Exam” | >

Scientists at the University of Connecticut Health, Yale University, and Johns Hopkins University have discovered that certain cancer cells possess the ability to evade limitations caused by oxygen deprivation, enabling the cancer cells to continue to grow.

The findings were recently published in the journal Cell Systems. The research was led by Kshitiz, an assistant professor in the Department of Biomedical Engineering, in collaboration with scientists Chi V. Dang from Johns Hopkins and Andre Levchenko from Yale.

Nearly a decade ago, the researchers observed a strange phenomenon while looking at cancer cells under hypoxia—or a lack of oxygen.

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An excellent overview of the story of how the U.S. responded to the COVID-19 pandemic along with suggestions for ways to continue making strides in combatting SARS-CoV-2 as well as how we may prepare for future emerging pathogens. The article provides an interesting case study on mechanisms of large-scale human organization, examines ways that we have succeeded in managing so many moving pieces, and explores ways that we could do better in the future. #nih #health #medicine #government #biotechnology

Investment, collaboration, and coordination have been key.

Francis Collins [email protected], Stacey Adam, […], Christine Colvis, Elizabeth Desrosiers, […], Ruxandra Draghia-Akli, Anthony Fauci, Maria Freire, Gary Gibbons, Matthew Hall, […], Eric Hughes, Kathrin Jansen, Michael Kurilla, H. Clifford Lane, Douglas Lowy, Peter Marks, Joseph Menetski, William Pao, Eliseo Pérez-Stable, Lisa Purcell, Sarah Read, Joni Rutter, Michael Santos, Tara Schwetz, Jeffrey Shuren, Timothy Stenzel, Paul Stoffels, Lawrence Tabak, Karen Tountas, Bruce Tromberg, David Wholley, Janet Woodcock, and John Young +29 authors +27 authors +22 authors fewer Authors Info & Affiliations

Science.

Continue reading “The NIH-led research response to COVID-19” | >

A Quebec hospital adopts a novel use of VR to help patients with anxiety, phobias and pain.

In a newswire release today, the Fondation de l’Hôtel-Dieu d’Alma (the Alma Hospital Foundation) announced the launch of a virtual reality (VR) project aimed at improving the mental health of those experiencing increasing anxiety. The Alma Hospital is a regional health centre for the area of Lac St. Jean and the Saguenay River valley to the north of Quebec City.

Jean Lamoureux, the hospital’s Executive Director states, “The number of requests for mental-health consultations is estimated to have increased by 30 to 40 percent during the pandemic. These needs are urgent…and, thanks to the innovation of Paperplane Therapeutics and TELUS, we will transform the way health services are delivered, while having a significant positive impact on patient well-being through technology.”

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Arizona State University has officially begun a new chapter in X-ray science with a newly commissioned, first-of-its-kind instrument that will help scientists see deeper into matter and living things. The device, called the compact X-ray light source (CXLS), marked a major milestone in its operations as ASU scientists generated its first X-rays on the night of Feb. 2.

“This marks the beginning of a new era of science with compact accelerator-based X‑ray sources,” said Robert Kaindl, who directs ASU’s Compact X-ray Free Electron Laser (CXFEL) Labs at the Biodesign Institute and is a professor in the Department of Physics. “The CXLS provides hard X-ray pulses with high flux, stability and ultrashort durations, in a very compact footprint. This way, matter can be resolved at its fundamental scales in space and time, enabling new discoveries across many fields — from next-generation materials for computing and information science, to renewable energy, biomolecular dynamics, drug discovery and human health.”

Building the compact X-ray light source is the first phase of a larger CXFEL project, which aims to build two instruments including a coherent X-ray laser. As the first-stage instrument, the ASU CXLS generates a high-flux beam of hard X‑rays, with wavelengths short enough to resolve the atomic structure of complex molecules. Moreover, its output is pulsed at extremely short durations of a few hundred femtoseconds — well below a millionth of one millionth of a second — and thus short enough to directly track the motions of atoms.

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𝐈𝐝𝐞𝐚𝐥 𝐛𝐥𝐨𝐨𝐝 𝐩𝐫𝐞𝐬𝐬𝐮𝐫𝐞 𝐦𝐚𝐲 𝐫𝐞𝐦𝐨𝐝𝐞𝐥 𝐛𝐫𝐚𝐢𝐧 𝐜𝐥𝐞𝐚𝐫𝐚𝐧𝐜𝐞 𝐩𝐚𝐭𝐡𝐰𝐚𝐲𝐬 𝐥𝐢𝐧𝐤𝐞𝐝 𝐭𝐨 𝐛𝐫𝐚𝐢𝐧 𝐡𝐞𝐚𝐥𝐭𝐡, 𝐝𝐞𝐦𝐞𝐧𝐭𝐢𝐚

𝘾𝙡𝙤𝙨𝙚 𝙧𝙚𝙫𝙞𝙚𝙬 𝙤𝙛 𝙈𝙍𝙄 𝙨𝙘𝙖𝙣𝙨 𝙛𝙤𝙪𝙣𝙙 𝙢𝙤𝙧𝙚 𝙞𝙣𝙩𝙚𝙣𝙨𝙞𝙫𝙚 𝙝𝙞𝙜𝙝 𝙗𝙡𝙤𝙤𝙙 𝙥𝙧𝙚𝙨𝙨𝙪𝙧𝙚 𝙩𝙧𝙚𝙖𝙩𝙢𝙚𝙣𝙩 (𝙩𝙖𝙧𝙜𝙚𝙩𝙚𝙙 𝙩𝙤 𝙖𝙘𝙝𝙞𝙚𝙫𝙚 𝙖 𝙨𝙮𝙨𝙩𝙤𝙡𝙞𝙘 𝙥𝙧𝙚𝙨𝙨𝙪𝙧𝙚 𝙡𝙚𝙨𝙨 𝙩𝙝𝙖𝙣 120 𝙢𝙢 𝙃𝙜) 𝙬𝙖𝙨 𝙢𝙤𝙧𝙚 𝙚𝙛𝙛𝙚𝙘𝙩𝙞𝙫𝙚 𝙩𝙝𝙖𝙣 𝙖 𝙡𝙚𝙨𝙨-𝙞𝙣𝙩𝙚𝙣𝙨𝙚 𝙩𝙧𝙚𝙖𝙩𝙢𝙚𝙣𝙩 𝙜𝙤𝙖𝙡 𝙤𝙛 140 𝙢𝙢 𝙃𝙜 𝙨𝙮𝙨𝙩𝙤𝙡𝙞𝙘 𝙞𝙣 𝙖𝙘𝙝𝙞𝙚𝙫𝙞𝙣𝙜 𝙖 𝙥𝙤𝙨𝙞𝙩𝙞𝙫𝙚 𝙨𝙩𝙧𝙪𝙘𝙩𝙪𝙧𝙖𝙡 𝙘𝙝𝙖𝙣𝙜𝙚 𝙞𝙣 𝙩𝙝𝙚 𝙗𝙧𝙖𝙞𝙣’𝙨 𝙥𝙚𝙧𝙞𝙫𝙖𝙨𝙘𝙪𝙡𝙖𝙧 𝙨𝙥𝙖𝙘𝙚𝙨: 𝙥𝙖𝙩𝙝𝙬𝙖𝙮𝙨 𝙩𝙝𝙖𝙩 𝙖𝙧𝙚 𝙞𝙢𝙥𝙤𝙧𝙩𝙖𝙣𝙩 𝙩𝙤 𝙘𝙡𝙚𝙖𝙧𝙞𝙣𝙜 𝙩𝙤𝙭𝙞𝙣𝙨 𝙖𝙣𝙙 𝙤𝙩𝙝𝙚𝙧 𝙗𝙮𝙥𝙧𝙤𝙙𝙪𝙘𝙩𝙨.

𝙄𝙛 𝙩𝙝𝙚 𝙗𝙧𝙖𝙞𝙣 𝙘𝙖𝙣𝙣𝙤𝙩 𝙥𝙧𝙤𝙥𝙚𝙧𝙡𝙮 𝙘𝙡𝙚𝙖𝙧 𝙢𝙚𝙩𝙖𝙗𝙤𝙡𝙞𝙘 𝙗𝙮𝙥𝙧𝙤𝙙𝙪𝙘𝙩𝙨, 𝙩𝙝𝙚𝙮 𝙖𝙘𝙘𝙪𝙢𝙪𝙡𝙖𝙩𝙚 𝙖𝙣𝙙 𝙢𝙖𝙮 𝙘𝙤𝙣𝙩𝙧𝙞𝙗𝙪𝙩𝙚 𝙩𝙤 𝙩𝙝𝙚 𝙙𝙚𝙫𝙚𝙡𝙤𝙥𝙢𝙚𝙣𝙩 𝙤𝙛 𝙙𝙚𝙢𝙚𝙣𝙩𝙞𝙖, 𝙧𝙚𝙨𝙚𝙖𝙧𝙘𝙝𝙚𝙧𝙨 𝙨𝙖𝙞𝙙.

Embargoed until 4 a.m. CT/5 a.m. ET, Thursday, Feb. 2, 2023

Continue reading “Ideal blood pressure may remodel brain clearance pathways linked to brain health, dementia” | >

Working with hundreds of thousands of high-resolution images, researchers from the Allen Institute for Cell Science, a division of the Allen Institute, put numbers on the internal organization of human cells — a biological concept that has proven incredibly difficult to quantify until now.

The scientists also documented the diverse cell shapes of genetically identical cells grown under similar conditions in their work. Their findings were recently published in the journal Nature.

“The way cells are organized tells us something about their behavior and identity,” said Susanne Rafelski, Ph.D., Deputy Director of the Allen Institute for Cell Science, who led the study along with Senior Scientist Matheus Viana, Ph.D. “What’s been missing from the field, as we all try to understand how cells change in health and disease, is a rigorous way to deal with this kind of organization. We haven’t yet tapped into that information.”

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