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Video games could give ophthalmologists an easy window not into the soul, but into eye health and the eye-brain-body connection — the three-way reciprocal communication that influences our actions.

“Infusing science into games is like sneaking broccoli into ice cream,” said Khizer Khaderi, MD, a clinical associate professor of ophthalmology. “It removes the resistance to do something that may not be viewed as fun, such as eating vegetables.” Or in this case, evaluating your vision health.

In a Stanford Medicine-led study, researchers employed video games to evaluate participants’ field of vision and visual stamina, their ability to distinguish contrast, and other factors that can indicate common eye diseases.

Researchers who previously developed the first 3D human cell culture models of Alzheimer’s disease (AD) that displays two major hallmarks of the condition—the generation of amyloid beta deposits followed by tau tangles—have now used their model to investigate whether the exercise-induced muscle hormone irisin affects amyloid beta pathology.

As reported in the journal Neuron, the Massachusetts General Hospital (MGH)–led team has uncovered promising results suggesting that irisin-based therapies might help combat AD.

Physical exercise has been shown to reduce deposits in various mouse models of AD, but the mechanisms involved have remained a mystery.

For the first time, scientists produced human kidneys out of chimeric embryos containing a mix of pig cells and human stem cells. The same technique can be used to produce heart and pancreas.

A team of Chinese researchers has successfully grown early-stage developing human kidneys into female pigs using chimeric embryos.

“This is the first time a solid human organ has been grown inside an animal species other than humans,” Liangxue Lai, senior study author and a biologist at the Guangzhou Institutes of Biomedicine and Health, told Interesting Engineering.

In findings with potentially important implications for cervical cancer screening, scientists at the Montefiore Einstein Cancer Center (MECC) have developed a test for detecting a type of cervical cancer that Pap tests often miss. The findings published online today in the JNCI: Journal of the National Cancer Institute.

“Our novel test appears sensitive for detecting cervical adenocarcinoma [ADC]—which now accounts for up to 25% of cervical cancer cases—as well as its precursor lesions, adenocarcinoma in situ [AIS], that often develop into ADCs,” said Howard Strickler, M.D., M.P.H., co-senior and corresponding author of the JNCI paper and a member of MECC.

“Because ADCs are often missed by current screening methods, they have higher mortality rates than the more common cervical squamous cell cancer,” Dr. Strickler added. “Our goal is to catch the disease early, before it develops into cancer.” Dr. Strickler is also professor and head of the division of epidemiology and the Harold and Muriel Block Chair in Epidemiology and Population Health at Albert Einstein College of Medicine.

A study has linked the development in kids of any of food allergy, asthma, eczema and rhinitis to a common factor – an unbalanced gut microbiome.

Researchers have long been intrigued by the gut microbiome in the development of allergic diseases. But this Canadian study is unique in identifying a common origin in infancy across the four separate allergic diseases. As well, it explored the composition of gut bacteria in children before and following allergic sensitization.

As each allergic disease has a separate list of symptoms, they are usually studied on their own. “But when you look at what is going wrong at a cellular level, they actually have a lot in common,” notes Dr. Charisse Petersen, co-senior author and a researcher at BC Children’s Hospital Research Institute and BC Children’s Hospital.

The pharmaceutical industry operates under one of the highest failure rates of any business sector. The success rate for drug candidates entering capital Phase 1 trials—the earliest type of clinical testing, which can take 6 to 7 years —is anywhere between 9% and 12%, depending on the year, with costs to bring a drug from discovery to market ranging from $1.5 billion to $2.5 billion, according to Science.

Andreessen Horowitz General Partner Vijay Pande, who oversees the firm’s health and bio fund, joins Bloomberg’s Ed Ludlow to discuss his AI strategy, and how generative AI can help safely engineer medicines at scale, support doctors and patients, and drive greater efficiency and better outcomes.
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The hyperactivity disorder, usually referred to as ADHD, is an independent risk factor for several common and serious mental health issues, finds research published in the open access journal BMJ Mental Health.

It is associated with , post , the eating disorder anorexia nervosa, and , the findings show, prompting the researchers to recommend vigilance by health professionals in a bid to ward off these disorders later on.

Attention-deficit/ (ADHD) is a neurodevelopmental condition in children and teens that extends into adulthood in up to around two thirds of cases. Worldwide, its prevalence is estimated to be around 5% in children/teens and 2.5% in adults.

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