Experts at Adelaide’s Flinders University have made an Alzheimer’s breakthrough that may result in world’s first dementia vaccine. Developed by Australian and US scientists, this vaccine may not only prevent but also reverse early stages of Alzheimer’s, the most common form of dementia.
The Alzheimer’s vaccine may be tested on humans within the next two to three years after being bankrolled by the US Government. Scientists from Flinders University and America’s Institute of Molecular Medicine and University of California developed the vaccine by targeting proteins in the brain that block neurons.
The formula targets tau proteins and abnormal beta-amyloid that cause Alzheimer’s. The scientists are confident that the vaccine would eventually be used as preventative vaccine. According to Flinders University medicine professor Nikolai Petrovsky, the proteins must be removed from the brain as Alzheimer’s, and dementia sufferers have lots of these broken down proteins inside.
I was asked this at Quora.com, where I answer questions under the pen name, ‘Ellery’. But the query deserves a companion question, and so I approached the reply by answering two questions.
You might have asked “Why was Bitcoin designed to have a cap?” But, instead, you asked “Why is the cap set at 21 million bitcoins”. Let’s explore both questions starting with the choice of a circulation cap…
Why set the cap at 21 million BTC?
The choice of a cap number is arbitrary and in fact, it could be 1 or it could be 1 hundred trillion. It makes no difference at all and it has no effect on the economy—even if Bitcoin were to be adopted as a currency all over the world. If it were set to 1 BTC, we would simply discuss nano-BTC instead of 1 BTC for amounts of about $650.
In fact, we already do this today. For many purposes, people are concerned with very small payments. And to best discuss these payments, we have the Satoshi. There are 100,000 Satoshi to each bitcoin (BTC).
What is important, is that the total number of bitcoin (regardless of how many units there are) can be divided into very tiny fractions. That way, the total worldwide supply can be divided into smaller and smaller slivers as market adoption gains traction. Everyone needs to earn, save, spend or pay with a piece of the pie. All users need to know is what fraction of the pie do I control? and not how many ounces, pounds, Kg, or tons is the pie. That is just a number.
Incidentally, the same could be said of gold (it can be shaved very thin), but gold is not quite like computer bits. It has industrial and cosmetic value, and this intrinsic demand for gold (beyond it’s role as a pure monetary instrument) has an effect on supply and demand along with the influence of investment, circulation, savings and reserve.
Why is there a cap at all?
At the beginning of this answer, I suggested another question: Why is Bitcoin capped at all? After all, the monetary supply in every country grows. Even gold production is likely to continue for centuries to come. Why not Bitcoin?
Satoshi designed Bitcoin to eventually become a deflationary currency. I believe that he/she recognized inflation is an insipid tax that constitutes an involuntary redistribution of earned wealth. With a firm cap on the total number of units that exist, governments can still tax, spend and even enforce tax collection. 
They can go about business building bridges, waging war and providing assistance to the needy. But without a printing press in the hands of transient politicians, they can only spend money with the consent of their constituents and residents.
Of course, they could borrow money by issuing bonds. But with a capped currency, each creditor would earnestly believe in the will and ability of the country to repay its debts.
In effect, monetary policy is restricted to the business of the governed, but the money itself is not coined by a domestic treasury. It is the province of something that is far more certain than a human institution. It arises from pure math. It is open and transparent. In effect, everyone is an auditor. That’s because the bookkeeping is crowd sourced.
For prescient legislators and national treasurers, Bitcoin presents far more of an opportunity than a threat. It is good for both government, business and consumers, because it forces everyone to be open and honest. Ultimately, it builds trust in government, because no one can cook the books, water down wealth, or print their way out of debt.
What about recession. Isn’t it a result of deflation?
Deflation doesn’t lead to recession. Rather, it sometimes accompanies a recession. Recession is caused by an uncertain job market, war, a massive supply chain interruption or political upheaval. In one way or another, it boils down to a lack of confidence sparked by one of the economy’s core foundations: consumers, investors, business or creditors.
Bitcoin as currency removes a major impediment to confidence. By creating a system that cannot be rigged, it fosters trust in government along with an open and transparent treasury.
Philip Raymond co-chairs CRYPSA and was MC at The Bitcoin Event in New York. He writes for Quora, LinkedIN, Wild Duck and Lifeboat Foundation, where he sits on the New Money Systems Board.
Translated this intriguing article for English readers about our soon to occur Mars-Colonisation, and prospective announcements at the upcoming SpaceX Event!
In our analysis of end 2015 (available on our website, and its summary in the English section) we tried to discern what might look like the project SpaceX Mars Colonization Transportation (MCT), Elon Musk has finally unveiled Sept. 27 at the next International Astronautical Congress. This year included the meagre clues gleaned from the various statements of the contractor, some alter the previous information (eg abandonment of multi-body launcher formula type Falcon Heavy) or, coercion, seemed to confirm the fundamental options such as refuelling earth parking orbit by a second launcher, the total reuse and descent of March of the entire interplanetary shuttle ( “landing the whole thing”). Since then, other indications of various origins have appeared on fans forums. Examine their possible significance.
The choice single-body launcher recoverable and we had driven to approach the performance target (100 T Payload deposited on Mars) to increase the diameter of the drive bay 15 m, although it seemed sufficient to limit that of upstairs itself to 12.5m (pm the first two stages of the Saturn 5 moon had a diameter of 10 m). This configuration allowed to stay a maximum of 31 engines of 300 T thrust and achieve take-off weight (GLOW) 7750 T. Unfortunately, the shape flared rear of the first floor, certainly favourable to the stability phase of ascent, is very unfavourable for the return (flight in opposite direction), especially since it has less then effective ways to stabilise the trajectory. Since it is difficult to imagine that we can reduce the GLOW and therefore the take-off thrust, the solution is to increase the diameter of the whole floor to 15 m. Now it is one of the rumours on forums “MCT-geeks”; SpaceX had solicited tooling suppliers for this diameter.
At the time, it evoked a Raptor 250 Tf thrust (optimal size for mass according SpaceX). Wishing nevertheless not to increase the number of engines (compared to what is allowed with the Falcon Heavy), we considered it necessary to increase the engine thrust to 300 Tf, that remained liveable in the 15 m the Bay. The problem is that even with this power, the desired performance is not achieved (unless we assume our assumptions about the structure of the masses too pessimistic shuttle); Indeed there were 90 T CU (referred to 100) and more in the most favourable conditions: Mars at perihelion and transfer long (Hohmann). But a noise is that SpaceX would work on a Raptor 700 Tf! This level of unit thrust would exceed the planned takeoff thrust, reached with 13 of these engines easily Lodgeable. Given the performance deficit, we can imagine that SpaceX, once the diameter of 15 m admitted, will seek to accommodate the maximum engine.
“Appearances have always played a much more important part than reality in history, where the unreal is always of greater moment than the real.“
–Gustav LeBon, The Crowd (1895)
I’ve gotten no substantive response to my last post on vaccine safety– neither in the comments, nor the TruthSift diagram, nor anywhere else, nor have the papers I submitted to two medical journals… but I have gotten emails telling me I’m delusional and suggesting I seek psychiatric attention. And this of course is integral to the explanation of how such delusions as vaccine safety persist so widely when it is so demonstrably a delusion: the majority who believe the majority must be right because its the majority are emotionally unwilling to confront the evidence. They assume the experts have done that, and they rely on the experts. But the experts assume other experts have been there. Ask your Pediatrician if he’s personally read Bishop et al and formulated an opinion on vaccine aluminum. Neither has the National Academy, except perhaps their members have and decided, perhaps tacitly, not to review the subject. Their decision not to review the animal literature was not tacit, they said they explicitly decided to omit it, although elsewhere they say they couldn’t find human evidence that addressed the issues. So everybody is trusting somebody else, and nobody has picked up the ball. And can you blame them? Because when I pick up the ball, what I receive in return is hate mail and people’s scorn. The emotional response cuts off any possible inspection of the logic.
On most questions where a majority with authority is facing a minority of dissenters or skeptics, the majority is delusional.
In other words, you are living in the matrix; much of what you and people believe is fundamentlaly wrong.
Reason 1, as above, is that the majority forms its view by circular reasoning, and rejects any attempt at logical discussion without considering it seriously, so it is prone to delusion.
Once the crowd concluded vaccines are safe and effective, for example, the question of whether the aluminum is damaging can apparently no longer be raised (even as more gets added to vaccines). And when I or others try to raise it, we are scorned and hated, and ineffectual in changing the opinion supported by circular reasoning. When new research papers appear that call it into question, they are ignored, neither cited in the safety surveys nor influencing medical practice in any way. This paragraph is all simple reporting of what has repeatedly happened.
Reason 2 is a minority wouldn’t be holding out without a good reason, because they are punished for their opposition with scorn and hatred at least. Except perhaps for explicitly religious issues, the usual reason they are so stubborn is they are defending rational truth.
Reason 3 is there’s often big money to be made or political power to be gained by influencing the majority opinion, and experts given good budgets appear to be pretty good at influencing majority opinion, especially with the aid of mass media, covertly staged stunts, and in many areas time enough to have long ago started from kids and education. On the other hand, rationality and reality don’t usually have press agents or forward looking media strategies, and there’s little or no money in swaying the minority position.
Show me a question with a majority with authority facing a minority where the majority isn’t delusional, and I’ll show you a minority that’s being paid under the table or planted to discredit rationalists in other controversial areas. At least I’ll suggest you strongly consider that as an alternative theory of what you see. The only one I can think of off hand are flat-earthers.
Mass Delusions were famously studied in 19th century first by Charles Mackay in
Popular Mass Delusions and the Madness of Crowds (1852) but more interestingly IMO in Gustave Le Bon, (1895) The Crowd. This latter was arguably the single book that had the most influence on the shape of the twentieth century. By their own accounts “The Crowd” was on Theodore Roosevelt’s bedside table, and dogeared by Mussolini. Lenin and Stalin took from it, and “Hitler’s indebtedness to Le Bon bordered on plagiarism” in the words of historian and Hitler-biographer Robert G. L. Waite. Sigmund Freud wrote a book discussing Le Bon, and Freud’s nephew Edward Bernays, acknowledged his deep debt, as Goebbels did of Bernays’ reflected insights.
Bernays equally isn’t as widely known as he should be. He invented the field of public relations, the “panel of doctors”, the slogan “making the world safe for democracy”, the diamond engagement ring, broke the taboo on women’s smoking and practically doubled sales by recruiting protesters smoking “torches of freedom”, bacon and eggs, and flouridated water, among many other things. There weren’t any decent safety studies on fluoridated water, and some modern studies say its taking multiple IQ points off the population, and nations and regions that don’t fluoridate have just as good teeth today as nations and regions that do, and putting fluoride in mouthwash and toothpaste rather than the drinking water would plainly have made a lot more sense from the point of view of public safety and health, but one thing you can count on: once he put it in the water supply and convinced everybody it was a health measure, you couldn’t sue for damage from fluoride runoff any more, and potentially multi-asbestos scale class action suits against the Government and aluminum manufacturers disappeared. Since Bernays got done, just raising the issue of fluoride gets you branded fruitcake and shunned to this day.
They are also still “making the world safe for democracy”, which he coined for WW1. But is this what they are doing, or is that another widely held delusion?
Bernays also wrote the book Propaganda which begins: “The conscious and intelligent manipulation of the organized habits and opinions of the masses is an important element in democratic society. Those who manipulate this unseen mechanism of society constitute an invisible government which is the true ruling power of our country.”
I’ve quoted from and summarized and discussed Le Bon extensively before so I will give only a brief flavor here.
“It is not necessary that a crowd should be numerous for the faculty of seeing what is taking place before its eyes to be destroyed and for the real facts to be replaced with hallucinations unrelated to them….
“To return to the faculty of observation possessed by crowds, our conclusion is that their collective observations are as erroneous as possible, and that most often they merely represent the illusion of an individual who, by a process of contagion, has suggestioned his fellows.”
“The events with regard to which there exists the most doubt are certainly those which have been observed by the greatest number of persons. To say that a fact has been simultaneously verified by thousands of witnesses is to say, as a rule, that the real fact is very different from the accepted account of it.”…
“By the mere fact that an individual forms part of a crowd, his intellectual standard is immediately and considerably lowered….
“The inferior reasoning of crowds is based, just as is the reasoning of a high order, on the association of ideas, but between the ideas associated by crowds there are only apparent bonds of analogy or succession. The mode of reasoning of crowds resembles that of the Esquimaux who, knowing from experience that ice, a transparent body, melts in the mouth, concludes that glass, also a transparent body, should also melt in the mouth…
The characteristics of the reasoning of crowds are the association of dissimilar things possessing a merely apparent connection between each other, and the immediate generalization of particular cases. It is arguments of this kind that are always presented to crowds by those who know how to manage them. They are the only arguments by which crowds are to be influenced. A chain of logical argumentation is totally incomprehensible to crowds…”
“When these convictions [of crowds] are closely examined,…, it is apparent that they always assume a particular form which I can not better define than giving it the name of a religious sentiment…
Intolerance and fanatacism are the necessary accompaniments of the religious sentiment. They are inevitably displayed by those who believe themselves in the possession of the secret of earthly or eternal happiness. These two characteristics are to be found in all men grouped together when they are inspired by a conviction of any kind. The Jacobins of the Reign of Terror were at bottom as religious as the Catholics of the Inquisition, and their cruel ardour proceeded from the same source. The convictions of crowds assume those characteristics of blind submission, fierce intolerance, and the need of violent propaganda which are inherent in the religious sentiment, and it is for this reason that it may be said that all their beliefs have a religous form.
Whether the feelings exhibited by a crowd be good or bad, they present the double character of being very simple and very exaggerated… a throng knows neither doubt nor uncertainty.”
The Red pill
So, now what’s in the red pill? Why, its a placebo. You can use any old red jelly bean. But if you swallow it and believe that the majority may be totally delusional about anything, and start looking into practically any subject with dissenters with an open mind, then I predict if you are skilled at critical thinking, you will shortways find the majority is in fact delusional, that is, you are indeed living in the matrix.
Much more widely than you are likely to imagine. For example, the news is basically propaganda, in lockstep among all the mainstream media, who accept whatever the government and political correctness tells them to believe uncritically. Was the passenger plane over Ukraine brought down by missile or strafing? Did the CDC conspire to hide a vaccine autism connection? Is the congress being run behind the scenes by a uniparty? You won’t find any of those subjects discussed unless to whitewash in the US mainstream media. What you want in a media system is ostensible diversity that conceals an actual uniformity. –Joseph Goebbels The history books are no better, as Le Bon observed. The banking system is all based on smoke and mirrors and a healthy skim. Etc.
I don’t expect TruthSift.com to convince the masses they are delusional, because Le Bon assures me logic will never sway a crowd, but I offer it as a tool to shortcut a lot of work for those who swallow the red pill. Rather than having to study a field in detail for years as I have with vaccines and needing to be able to supply PhD level understanding of what you are reading and needing the confidence of your convictions against the many, you can much more rapidly peruse a diagram and find what the real situation is, assuming the diagram has been created and debated.
So I beg readers here to create such diagrams on TruthSift for any topic you are interested in.
Of course, they are fun and interesting too.
I also commend TruthSift to corporations and others wanting to escape the kind of crowd think delusions so well characterized by Le Bon, and achieve actual rationality in your decisions. Use it on Private Diagrams. Everybody in your organization will be able to contribute to the document, if you invite them, exactly where its pertinent. It will naturally divide and conquer your problems in ways where different people can address different problems, achieving true collaboration. Nobody will be able to get confused or pursue some other agenda without being transparently refereed. The answer will be far more rationally derived and argued for than what you are doing now. You can allow people to contribute under pseudonyms if you want. http://TruthSift.com
Listen up all my QC buddies; the air force wants to hear from you. You have QC ideas for fighter jets they want you.
Guess I need to submit them some of mine.
The Air Force wants white papers that describe new ways quantum computing could help achieve its mission, according to an amended Broad Agency Announcement posted Friday. Eventually, the government could provide a test-bed where a contractor might install, develop and test a quantum computing system, according to the announcement.
Last year, the Air Force announced it had about $40 million available to fund research into, and the eventual maintenance and installation of a quantum system — a branch of emerging computing technology that relies on the mechanics of atomic particles to process complex equations.
The Air Force Research Laboratory’s Information Directorate, which focuses on processes such as signal processing, networking technology, cyber research and supercomputing, is collecting those white papers.
You got to luv this one.
The security agency must defend itself in a US appeals court for violating the rights of a convicted bomber by supposedly illegally spying on him.
A US appeals court will weigh a constitutional challenge on Wednesday to a warrantless government surveillance program, brought by an Oregon man found guilty of attempting to detonate a bomb in 2010 during a Christmas tree-lighting ceremony.
The case before a three-judge panel of the 9th US Circuit Court of Appeals is the first of its kind to consider whether a criminal defendant’s constitutional privacy rights are violated under a National Security Agency (NSA) program that allows spying on Americans’ international phone calls and internet communications.
Nice that they are trying to ensure this. However, as we integrate more tech into Biocomputing space and our efforts in achieving singularity; you will need some level of a medical/ or bio background.
It’s hard enough for IT security managers to keep with the latest in conventional computing. Cloud Security Alliance and the US government are trying to make sure you don’t need a physics degree, too.
Like the USPS; could we see a day when DARPA and IARPA positioned to be revenue generators like big tech? Granted these 2 programs are tax payer funded; however, so is USPS. One option is to for a contracted service fee; could DARPA &/ or IARPA charge fees to tech companies and others for using their technologies?
Two of the most important technological advances that helped fueled much of the country’s record economic growth in the post-WW II era were ubiquitous computing devices and modern communications technologies.
Indeed, most of the companies covered on TechCrunch certainly would not exist if not for the development and commercialization of microprocessors and the internet.
In my opinion, insufficient attention in the current ideological debate taking place in Silicon Valley and around the country has been given to the important role that government played throughout the lifecycle of these technologies. Understanding how these relatively mature technologies and industries were initially spawned and encouraged is critical to developing a strategy to empower the next generation of entrepreneurs in capital- or R&D-intensive industries with high growth potential.
