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Category: genetics – Page 543

CRISPR/Cas9 has been touted as an almost magical technology in the news—and rightly so. The technique allows scientists to alter the DNA of living cells and, it’s hoped, achieve a longstanding goal of science to treat disease at the genetic level.

That’s a really big deal.

An estimated 6,000 diseases are caused by genetic mutations, and only 5% can be treated. Take sickle-cell anemia, for example. Often deadly, it is caused by a single mutation in one of the human body’s three billion DNA base pairs. It’s a small, well-understood error in the genetic code, but so far we have been helpless to repair it.

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Interesting perspective of the world and globalization.

It is my belief that we are heading toward a blend of Islandization and Commonization. World transformation is powered first and foremost by the mega-driver of technology, which in turn is central to both of these worlds. The most significant change in the past seven years of world history is that we have entered into a period of sustained technological progress. I fully expect in coming years further breakthroughs in areas including alternative energy, biotechnology and artificial intelligence that dramatically change our economies and our societies.

Unfortunately, I am less sure that technological change will be positive. The exploitation by violent extremists of social media is a case in point of the double-edge that new technologies can bring. This is an extremely disruptive and dislocating time for individuals, organizations and governments alike. The net gain of technology will almost certainly be positive, but there will be winners and losers, and losers will not necessarily go quietly. Nor will the winners necessarily perceive objective gain as actual gain. And some new technologies, such as the gene-editing powers of CRISPR, point to a highly uncertain future.

In our days together in Davos, I will focus my conversations on this new age of exploration in a post-globalization world. As the next global order takes hold, organizational foresight and agility will be critical in determining winners and losers in the new global operating environment.

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Yeah, he’s turned into quite the man-of-panic as of late.

Stephen Hawking is at it again, saying it’s a “near certainty” that a self-inflicted disaster will befall humanity within the next thousand years or so. It’s not the first time the world’s most famous physicist has raised the alarm on the apocalypse, and he’s starting to become a real downer. Here are some of the other times Hawking has said the end is nigh—and why he needs to start changing his message.

Speaking to the Radio Times recently ahead of his BBC Reith Lecture, Hawking said that ongoing developments in science and technology are poised to create “new ways things can go wrong.” The scientist pointed to nuclear war, global warming, and genetically-engineering viruses as some of the most serious culprits.

“Although the chance of a disaster on planet Earth in a given year may be quite low, it adds up over time, becoming a near certainty in the next thousand or ten thousand years,” he was quoted as saying. “By that time we should have spread out into space, and to other stars, so it would not mean the end of the human race. However, we will not establish self-sustaining colonies in space for at least the next hundred years, so we have to be very careful in this period.”

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In less than 4 yrs. 5 million jobs will be lost is the prediction.

A new report predicts a loss of 5 million jobs in the next five years because of technological advances, but don’t blame it all on the robots.

The other culprits: artificial intelligence, 3-D printers and advances in genetics, biotech and more.

The World Economic Forum, which is holding its annual meeting in Davos this week, in its report details the effects of modern technology on the labor market, for better or for worse. It says “the fourth industrial revolution” will be “more comprehensive and all-encompassing than anything we have ever seen.”

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Although the recent article and announcement of Josiah Zayner (CA scientist) new do it yourself gene editing kit for $120 sent shock waves across industry as well as further raised the question “how do we best put controls in place to ensure ethics and prevent disaster or a crisis?”; this genie truly is out of the bottle. Because Josiah created this easily in his own kitchen, it can be replicated by many others in their own homes. What we have to decide is how to best mitigate it’s impact. Black markets & exotic animal, etc. collectors around the world will pay handsomely for this capability and raise the stakes of the most bizarre animals (deadly and non-deadly) to be created for their own profits and amusements.

BURLINGAME, Calif. — On the kitchen table of his cramped apartment, Josiah Zayner is performing the feat that is transforming biology. In tiny vials, he’s cutting, pasting and stirring genes, as simply as mixing a vodka tonic. Next, he slides his new hybrid creations, living in petri dishes, onto a refrigerator shelf next to the vegetables. And he’s packaging and selling his DIY gene-editing technique for $120 so that everyone else can do it, too.

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The article states that European royal houses are all closely related. Well in humanities history it’s thought that over 80% of all marriages were between second cousins or closer. While until the industrial revolution the nobility would have been the only demographic who could travel further than as far as you can walk from your home and back in a day. So until the industrial revolution the nobility were probably the most genetically diverse demographic.

‘Virgin births’ happen in nature more than we thought, says Frank Swain, so what’s stopping human beings from doing the same?

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Excellent news; Intellia to continue their focus of leveraging the CRISPR/Cas9 across a variety of immune cells, such as natural killer cells and T-cells. From my own experiences with T-cells and other blood disorders; this is a big deal and one that I personally excited to see what potential cures and improvements come about.

CAMBRIDGE, Mass.–()–Intellia Therapeutics, a leading gene-editing company, has launched a new division, eXtellia Therapeutics, with the intent of focusing resources and research on ex vivo applications of the novel technology, CRISPR/Cas9. As in vivo and ex vivo programs require different competencies in research, manufacturing and commercialization, eXtellia Therapeutics is being launched to accelerate Intellia’s efforts in areas of significant unmet medical need – immuno-oncology, autoimmune and inflammatory diseases – using an ex vivo approach. Intellia will continue its in vivo programs and strategy through a dedicated scientific team.

“We are excited to announce the establishment of eXtellia, increasing our footprint in ex vivo gene editing for oncology and autoimmune diseases,” said Nessan Bermingham, Ph.D., Chief Executive Officer and Founder, Intellia Therapeutics. “eXtellia enables us to bring together the required capabilities needed to take the CRISPR/Cas9 technology beyond Intellia’s emerging in vivo, HSC and CAR-T efforts. We believe eXtellia further positions us to maximize the CRISPR/ Cas9 opportunity to address severe unmet medical needs for patients.”

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This is excellent news for Epilepsy.

Epilepsy, a disorder in which nerve cell activity in the brain is disturbed, causing seizures, is the fourth most common neurological problem, following only migraine, stroke and Alzheimer’s. There is no cure for epilepsy, but there are a variety of treatment options. The disease is estimated to affect 2.2 million people in the U.S., with 150,000 people developing the condition each year.

Personalized medicine Scientists at AES discussed how new technologies, such as gene editing using CRISPR-Cas9, and next-generation sequencing, are empowering them to take a new crack at the human genome and find new ways to diagnose and treat epilepsy.

“Recent advances in DNA sequencing and genomic technologies has facilitated a flood of discoveries in identifying genetic causes of epilepsy. Where we’ve been most successful is in the epileptic encephalopathies (EE),” lead author of one of the studies presented, Candace Myers, a senior at the University of Washington, said in a press conference.

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