We’re continuing to release talks from Ending Age-Related Diseases 2019, our highly successful two-day conference that featured talks from leading researchers and investors, bringing them together to discuss the future of aging and rejuvenation biotechnology.
Dr. Greg Fahy of Intervene Immune gave a presentation about his company’s Phase 1 human trials in which the thymus, a critical organ of the immune system, was regenerated through a combination of existing drugs, restoring immune function and causing epigenetic biomarkers to show rejuvenation.
Over 3 million new cases of dermatitis appear in the US per year. Although dermatitis is broadly defined by the sensitivity of the skin, the condition is actually further segmented by a group of diseases. By far the most popular of these is atopic dermatitis, alternatively and perhaps more popularly known as eczema, affecting about 30% of the population. Genetics and environmental factors are the most conclusive predictors but no cause has ever been explicitly determined. The pathology is able to be determined physically, as inflamed skin grows craked and hardens.
Though a new report published in the Journal of the American Academy of Dermatology presents some internal risk increases for sufferers to consider. The Danish researchers set out to examine the association between hospital-diagnosed atopic dermatitis and atrial fibrillation, writing in the report, “Atopic dermatitis is characterized by chronic inflammation, which is a risk factor for atrial fibrillation. P atients with hospital-diagnosed atopic dermatitis have a 20% increased long-term risk of atrial fibrillation, but the absolute risk remains low.”
“97% of human DNA is genetic code from alien life forms.” scientists who spent 13 years working on the human genome have sensationally claimed…Watch Part 2 Now: https://www.youtube.com/watch?v=jtic3xF2wqI&t=14s
Guppies, a perennial pet store favorite, have helped a UC Riverside scientist unlock a key question about evolution:
Do animals evolve in response to the risk of being eaten, or to the environment that they create in the absence of predators? Turns out, it’s the latter.
David Reznick, a professor of biology at UC Riverside, explained that in the wild, guppies can migrate over waterfalls and rapids to places where most predators can’t follow them. Once they arrive in safer terrain, Reznick’s previous research shows they evolve rapidly, becoming genetically distinct from their ancestors.
Prof. Steve Fuller is the author of 25 books including a trilogy relating to the idea of a ‘post-’ or ‘trans-‘human future, and most recently, Nietzschean Meditations: Untimely Thoughts at the Dawn of the Transhuman Age.
During this 2h 15 min interview with Steve Fuller we cover a variety of interesting topics such as: the social foundations of knowledge and our shared love of books; Transhumanism as a scientistic way of understanding who we are; the proactionary vs the precautionary principle; Pierre Teilhard de Chardin and the Omega Point; Julian and Aldous Huxley’s diverging takes on Transhumanism; David Pearce’s Hedonistic Imperative as a concept straight out of Brave New World; the concept and meaning of being human, transhuman and posthuman; humanity’s special place in the cosmos; my Socratic Test of (Artificial) Intelligence; Transhumanism as a materialist theology – i.e. religion for geeks; Elon Musk, cosmism and populating Mars; de-extinction, genetics and the sociological elements of a given species; the greatest issues that humanity is facing today; AI, the Singularity and armed conflict; morphological freedom and becoming human; longevity and the “Death is Wrong” argument; Zoltan Istvan and the Transhumanist Wager; Transhumanism as a way of entrenching rather than transcending one’s original views…
As always you can listen to or download the audio file above or scroll down and watch the video interview in full. To show your support you can write a review on iTunes, make a direct donation or become a patron on Patreon.
If used to make non-heritable genetic changes, CRISPR gene-editing technology holds tremendous promise for treating or curing a wide range of devastating disorders, including sickle cell disease, vision loss, and muscular dystrophy. Early efforts to deliver CRISPR-based therapies to affected tissues in a patient’s body typically have involved packing the gene-editing tools into viral vectors, which may cause unwanted immune reactions and other adverse effects.
Now, NIH-supported researchers have developed an alternative CRISPR delivery system: nanocapsules. Not only do these tiny, synthetic capsules appear to pose a lower risk of side effects, they can be precisely customized to deliver their gene-editing payloads to many different types of cells or tissues in the body, which can be extremely tough to do with a virus. Another advantage of these gene-editing nanocapsules is that they can be freeze-dried into a powder that’s easier than viral systems to transport, store, and administer at different doses.
In findings published in Nature Nanotechnology [1], researchers, led by Shaoqin Gong and Krishanu Saha, University of Wisconsin-Madison, developed the nanocapsules with specific design criteria in mind. They would need to be extremely small, about the size of a small virus, for easy entry into cells. Their surface would need to be adaptable for targeting different cell types. They also had to be highly stable in the bloodstream and yet easily degraded to release their contents once inside a cell.
On its surface, the plan was simple: gene-hack mosquitoes so their offspring immediately die, mix them with disease-spreading bugs in the wild, and watch the population drop off. Unfortunately, that didn’t quite pan out.
The genetically-altered mosquitoes did mix with the wild population, and for a brief period the number of mosquitoes in Jacobino, Brazil did plummet, according to research published in Nature Scientific Reports last week. But 18 months later the population bounced right back up, New Atlas reports — and even worse, the new genetic hybrids may be even more resilient to future attempts to quell their numbers.
Age is not the definitive factor it’s made out to be when it comes to our health. We can use our age as a baseline for tracking our health and longevity, but it isn’t stagnant. For example, certain types of testing can help us compare our biological age to our calendar age in order to tinker with our wellness routine and achieve the milestones we’re after. With the right steps, we can slow down and even sometimes reverse the aging process.
When it comes to our biological age, or the measure of how well our body is actually functioning for whatever life stage we are in, there are many things that impact it. Diet, lifestyle patterns like exercise and sleep, and stress are all involved in forming our biological age, along with many other factors like blood sugar, inflammation, and genetics. This week on The Doctor’s Farmacy, I’m joined by Dr. David Sinclair to explore the topic of longevity and anti-aging and how he reduced his own internal age by more than 20 years. Dr. Sinclair is a professor in the Department of Genetics and co-director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School, where he and his colleagues study longevity, aging, and how to slow its effects.
This episode of The Doctor’s Farmacy is brought to you by ButcherBox. Now through September 29, 2019, new subscribers to ButcherBox will receive ground beef for life. When you sign up today, ButcherBox will send you 2lbs of 100% pasture-raised grass-fed, grass finished beef free in every box for the life of your subscription. Plus listeners will get an additional $20 off their first box. All you have to do is head over to ButcherBox.com/farmacy _____________________________________
Dr. Hyman is an 11-time New York Times bestselling author, family physician and international leader in the field of Functional Medicine. His podcast, The Doctor’s Farmacy, is a place for deep conversations about the critical issues of our time in the space of health, wellness, food and politics. New episodes are released every Wednesday here on YouTube, and wherever you listen to podcasts.
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