Category: futurism – Page 81
A glycolytic shunt via the pentose phosphate pathway is a metabolic checkpoint for nervous system sensory homeostasis and axonal regeneration
Pentose phosphate pathway in axonal regeneration.
Various signaling pathways play an important role in neuronal homeostasis and regeneration.
The researchers in this study determine that the pentose phosphate pathway (PPP) plays a dual role in enabling homeostatic and regenerative adaptations to environmental stimuli and injuries.
They show that sciatic nerve axoplasms are enriched PPP and maintains redox balance via NADPH production but following sciatic nerve injury, the PPP is required for regeneration by fueling ribonucleotide synthesis through ribose-5-phosphate.
However, after spinal cord injury (SCI), PPP remain inactive and neuronal transketolase overexpression or oral ribose supplementation, promotes metabolic reprogramming, restores sensory and motor axonal growth. sciencenewshighlights ScienceMission https://sciencemission.com/pentose-phosphate-pathway-is-a-metabolic-checkpoint
The pentose phosphate pathway plays a dual role in enabling homeostatic and regenerative adaptations to environmental stimuli and injuries and can be leveraged to promote regeneration and recovery after spinal cord injury.
The Immune Chain Reaction That Raises Colon Cancer Risk in IBD
A hidden immune cascade linking the gut and bone marrow may explain how IBD turns inflammation into colon cancer.
Scientists at Weill Cornell Medicine have identified a complex immune process in the gut that may help explain why people with inflammatory bowel disease (IBD) face a much higher risk of colorectal cancer. The preclinical study shows how a specific immune signal can trigger a wave of white blood cells from the bone marrow into the gut, creating conditions that support tumor growth. The findings also suggest new approaches for detecting disease activity, tracking risk, and developing future treatments.
The role of TL1A in gut inflammation.
Detection of THC Impairment Using Functional Near-Infrared Spectroscopy
Among adults receiving oral THC, portable fNIRS scans detected impairment with higher accuracy and fewer false positives than field sobriety tests, supporting fNIRS as a more objective approach for cannabis impairment detection.
This crossover trial compares the accuracy of resting-state functional near-infrared spectroscopy vs standard field sobriety testing to detect ∆9-tetrahydrocannabinol (THC) impairment among adults who use cannabis.
It’s 2 miles deep, close to a volcano, the size of 233 soccer fields and home to a whopping 20,000 creatures
The world’s biggest octopus aggregation is made up of thousands of these usually solitary creatures