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Researchers demonstrate vaccination approach in mice that could prevent future coronavirus outbreaks

Researchers in Japan have developed a vaccination strategy in mice that promotes the production of antibodies that can neutralize not only SARS-CoV-2 but a broad range of other coronaviruses as well. If successfully translated to humans, the approach, to be published October 8 in the Journal of Experimental Medicine, could lead to the development of a next-generation vaccine capable of preventing future coronavirus pandemics.

The SARS-CoV-2 virus responsible for COVID-19 enters human cells by using its to bind to a called ACE2. The receptor-binding domain of the spike protein consists of two parts: a “core” region that is very similar in all coronaviruses, and a more specialized “head” region that mediates binding to ACE2.

Antibodies that recognize the head region of the spike receptor-binding domain can block the entry of SARS-CoV-2 into cells but offer little protection against other coronaviruses, such as the SARS-CoV-1 virus responsible for the severe acute respiratory syndrome outbreak of 2002. Antibodies that recognize the core region of the spike receptor-binding domain, in contrast, can prevent the entry of various coronaviruses into . Unfortunately, however, individuals exposed to the viral spike protein tend to produce lots of against the head region but few, if any, antibodies that recognize the core region.

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The Future Of AI-Driven Meeting Technology

Early in 2,021 the Stanford Virtual Human Interaction Lab looked at the psychological consequences of spending long days videoconferencing and in virtual meetings. The popularized term “Zoom fatigue,” is the result of maxing out cognitive load and even reducing effectiveness. For all of that investment in remote work technology, senior managers feel there is very little payoff.

The University of North Carolina surveyed 182 senior managers and 65% of them felt meetings kept them from completing their own work, 71% felt meetings were inefficient and unproductive, and 64% felt meetings undercut deep thinking.

As technology-dependent remote workers proliferate, new solutions are coming to the fore that may make both in-person and virtual meetings more productive.

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