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Gene regulation in animals depends chiefly on enhancers, yet the underlying mechanisms are poorly understood. This Review discusses enhancer–promoter interactions and transcription activation, focusing on how enhancer–promoter selectivity is achieved and on recent technical advances that may provide new insights into transcription activation.

Passengers who book a special Delta flight will have the chance to witness the total solar eclipse in April from a unique vantage point: 30,000 feet in the air.

The airline announced Monday that it will operate a flight on April 8 from Dallas-Fort Worth to Detroit, timed to give people on board the chance to spend as much time as possible within the eclipse’s “path of totality.”

The eclipse is expected to be a major event because it will pass over several densely populated areas of North America, crossing Mexico, the continental U.S. and a small part of eastern Canada. In the U.S. alone, millions of skywatchers from Texas to Maine will have the chance to witness the rare astronomical event.

Topological wave structures are wave patterns that exhibit specific topological properties, or in other words, properties that remain unvaried under smooth deformations of a physical system. These structures, such as vortices and skyrmions, have attracted significant attention within the physics research community.

While physicists have carried out extensive studies focusing on topological wave structures in various wave systems, surprisingly their most classical example remains unexplored. These are water waves, oscillations or disturbances that propagate on the surface of water or other fluid.

Researchers at RIKEN recently set out to fill this gap in the literature, by offering a description of various water-wave topological structures. Their paper, published in Physical Review Letters, offers a theoretical framework that could inform future experiments aimed at emulating topological wave phenomena.