Cheaper, brighter, and greener, perovskite LEDs could change lighting — if they last long enough.
Envision this possible future clinical scenario: a breast cancer patient and her physicians are deciding on the best possible treatment. Their decision is informed by a comprehensive molecular profile of the patient’s cancer samples that predicts the most likely response of the cancer to treatment.
If the profile predicts a high likelihood of a complete positive response and long-term freedom from relapse, then this treatment would be the preferred choice. But if the profile predicts that the tumor would likely be resistant to treatment, alternative treatments must be implemented.
Although this situation is not yet a reality, a team led by researchers at Baylor College of Medicine and the Broad Institute of Massachusetts Institute of Technology and Harvard has taken significant steps in that direction. They report in Cell Reports Medicine that conducting an integrated proteogenomic profiling of cancer cells, which combines the analysis of DNA, RNA, protein and phosphoprotein data, revealed two novel indicators of tumor response to treatment and alternative therapeutic targets for treatment-resistant HER2+ breast cancer.
The Vera C. Rubin Observatory in Chile will image the southern sky using the largest digital camera ever built.
A quick overview of some of the most popular fictional architectural styles.
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00:00 Cyberpunk.
00:37 Steampunk.
01:14 Dieselpunk.
01:46 Atompunk.
02:22 Solarpunk.
02:58 Biopunk.
03:33 Post-Apocalyptic Salvagecore.
04:07 Brutalist Dystopia.
04:40 Arcology.
05:16 Space-Opera Modernism.
05:52 Dark Fantasy.
06:25 Clockpunk.
06:58 Teslapunk.
07:29 Afrofuturist.
08:02 Subnautical Artifice
Contrary to the popular saying, rules aren’t meant to be broken, as they are foundational to society and exist to uphold safety, fairness and order in the face of chaos. The collective benefits of rule-following are well established, but individual incentives are often unclear. Yet, people still comply, and the reasons why are pieces of a puzzle that researchers of human behavior have been trying to piece together for years.
A recent study published in Nature Human Behavior explored the behavioral principles behind why people follow rules using a newly designed framework called CRISP. A series of four online experiments based on the framework involving 14,034 English-speaking participants, revealed that the majority (55%–70%) of participants chose to follow arbitrary rules—even when the compliance was costly, they were anonymous and violations had no adverse effects on others.
This proposed CRISP system explains rule conformity © as a function of four components: R—intrinsic respect for rules, independent of others’ behavior; I—extrinsic incentives, such as the threat of punishment for breaking rules; S—social expectations about whether others will follow the rule or believe one should; and P—social preferences, which matter when rule-following affects the well-being of others.