Elon Musk’s X is using its new jobs listing service to recruit engineers, and the billionaire promoted it by referencing incoming soda machines.
Video games could give ophthalmologists an easy window not into the soul, but into eye health and the eye-brain-body connection — the three-way reciprocal communication that influences our actions.
“Infusing science into games is like sneaking broccoli into ice cream,” said Khizer Khaderi, MD, a clinical associate professor of ophthalmology. “It removes the resistance to do something that may not be viewed as fun, such as eating vegetables.” Or in this case, evaluating your vision health.
In a Stanford Medicine-led study, researchers employed video games to evaluate participants’ field of vision and visual stamina, their ability to distinguish contrast, and other factors that can indicate common eye diseases.
If you want to read a long and complex article on EMF and oxidative stress, here’s one. And when I did a Google search on my Pixel 6 that has generative results, the result said it affected the blood brain barrier but I think it combined several websites as a source and summarized them. I’ll post a screenshot.
Free radicals are reactive molecules produced during the conversion of foods into energy through oxygen. The formation of free radicals is an oxidation reaction that occurs on an oxygen basis. [27]. Since oxygen is essential for survival, the formation of free radicals cannot be avoided. However, factors including ionizing and non-ionizing radiation alter the transcription and translation of genes such as JUN, HSP 70 and MYC, via the epidermal growth factor receptor EGFR-ras, leading to the generation of ROS [28,29] and resulting in the overproduction of ROS in tissues [30].
The Fenton reaction is a catalytic process that converts hydrogen peroxide, a product of mitochondrial oxidative respiration, into a highly toxic hydroxyl free radical. Some studies have suggested that EMF is another mechanism through the Fenton reaction, suggesting that it promotes free radical activity in cells [31,32]. Although some researchers have reported that ROS perform beneficial function, a high degree of ROS production may cause cellular damage, resulting in a range of diseases. These radicals react with various biomolecules, including DNA ( Fig. 1 ). Namely, the energy of free radicals is not enough, and for this reason they behave like robbers who seize energy from other cells and rob a person to satisfy themselves [33]. Many studies have suggested that EMF may trigger the formation of reactive oxygen species in exposed cells in vitro [34,35,36,37] and in vivo [7, 31,38]. The initial stage of the ROS production in the presence of RF is controlled by the NADPH oxidase enzyme located in the plasma membrane. Consequently, ROS activate matrix metalloproteases, thereby initiating intracellular signaling cascades to warn the nucleus of the presence of external stimulation. These changes in transcription and protein expression are observed after RF exposure [39]. Kazemi et al. investigated the effect of exposure to 900-MHz on the induction of oxidative stress and the level of intracellular ROS in human mononuclear cells. Excessive elevation in ROS levels is an important cause of oxidative damage in lipids and proteins and nucleic acids. It therefore causes changes in enzyme activity and gene expression, eventually leading to various diseases, including sleep disorder, arthrosclerosis, loss of appetite, diabetes, dizziness, rheumatoid arthritis, cardiovascular disease, nausea and stroke [40,41,42]. In addition, degradation of the pro-oxidant-antioxidant balance due to an uncontrolled increase in ROS may also result in lipid peroxidation. Lipid peroxidation is the process in which cell membranes are rapidly destroyed due to the oxidation of components of phospholipids containing unsaturated fatty acids. By continuing this reaction, lipid peroxides (-C0, H) accumulate in the membrane, and transform polyunsaturated fatty acids into biologically active substances [43]. Consequently, lipid peroxidation leads to significant damage in the cells, such as disturbances in membrane transport, structural changes, cell membrane fluidity, damage to protein receptors in membrane structures, and changes in the activity of cell membrane enzymes [44]. Hoyto et al. demonstrated significant induction of lipid peroxidation after exposure to EMF in the mouse SH-SY5Y cell and L929 fibroblast cells [45]. Epidemiological studies have also suggested that oxidative damage to lipids in blood vessel walls may be a significant contributor to the development of atherosclerosis [46,47,48].
Many believe the future of humanity is to go Digital, uploading our minds to computers, living in virtual worlds that are vastly more efficient and compact. If we might do this, might distant alien empires too? And if so, might this be the reason we don’t see them?
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Continue reading “The Fermi Paradox: Digital Empires & Miniaturization” »
Disrupted connections between memory and appetite regulating brain circuits are directly proportional to body mass index (BMI), notably in patients who suffer from disordered or overeating that can lead to obesity, such as binge eating disorder (BED), according to new research from the Perelman School of Medicine at the University of Pennsylvania. Published today in Nature, the research notes that individuals who are obese have impaired connections between the dorsolateral hippocampus (dlHPC) and the lateral hypothalamus (LH), which may impact their ability to control or regulate emotional responses when anticipating rewarding meals or treats.
“These findings underscore that some individual’s brains can be fundamentally different in regions that increase the risk for obesity,” senior author, Casey Halpern, MD, an associate professor of Neurosurgery and Chief of Stereotactic and Functional Neurosurgery at Penn Medicine and the Corporal Michael J. Crescenz Veterans Affairs Medical Center. “Conditions like disordered eating and obesity are a lot more complicated than simply managing self-control and eating healthier. What these individuals need is not more willpower, but the therapeutic equivalent of an electrician that can make right these connections inside their brain.”
The dlHPC is located in the region of the brain that processes memory, and the LH is in the region of the brain that is responsible for keeping the body in a stable state, called homeostasis. Previous research has found an association with loss of function in the human hippocampus in individuals with obesity and related disordered eating, like BED. However, outside of imaging techniques such as magnetic resonance imaging (MRI), the role of the hippocampus has been difficult to study in humans with obesity and related eating disorders.
A study has linked the development in kids of any of food allergy, asthma, eczema and rhinitis to a common factor – an unbalanced gut microbiome.
Researchers have long been intrigued by the gut microbiome in the development of allergic diseases. But this Canadian study is unique in identifying a common origin in infancy across the four separate allergic diseases. As well, it explored the composition of gut bacteria in children before and following allergic sensitization.
As each allergic disease has a separate list of symptoms, they are usually studied on their own. “But when you look at what is going wrong at a cellular level, they actually have a lot in common,” notes Dr. Charisse Petersen, co-senior author and a researcher at BC Children’s Hospital Research Institute and BC Children’s Hospital.
Inside our bodies at every moment, our cells are orchestrating a complex dance of atoms and molecules that uses energy to create, distribute and deploy the substances on which our lives depend.
And it’s not just in our bodies: all animals carry out this dance of metabolism, and it turns out none of them do it quite the same way.
In new research published in Science Advances, we analysed specific carbon atoms in amino acids – the building blocks of proteins – to discover distinctive fingerprints of the metabolism of different species.
The hyperactivity disorder, usually referred to as ADHD, is an independent risk factor for several common and serious mental health issues, finds research published in the open access journal BMJ Mental Health.
It is associated with major depression, post traumatic stress disorder, the eating disorder anorexia nervosa, and suicide attempts, the findings show, prompting the researchers to recommend vigilance by health professionals in a bid to ward off these disorders later on.
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental condition in children and teens that extends into adulthood in up to around two thirds of cases. Worldwide, its prevalence is estimated to be around 5% in children/teens and 2.5% in adults.
In new research published in BMC Medicine, the authors recruited a large cohort of participants in order to assess how plant-based foods affect aging trajectories [1].
Previous research has shown that consumption of plant-based foods is associated with healthy aging [2,3]. It can also help to decrease the risk of mortality [4], prevent the development of chronic diseases [5,6], and improve neurological health, such as by lowering the risk of dementia [7] and cognitive impairment [8].
This new study aimed to determine the influence of a plant-based diet on the aging trajectory of the middle-aged Asian population. Researchers recruited over 10,000 people 50 years and older in Taiwan. Participants provided health data four times during the eight years after enrollment, underwent physical examinations, and filled out relevant questionnaires.
Other questions to the experts in this canvassing invited their views on the hopeful things that will occur in the next decade and for examples of specific applications that might emerge. What will human-technology co-evolution look like by 2030? Participants in this canvassing expect the rate of change to fall in a range anywhere from incremental to extremely impactful. Generally, they expect AI to continue to be targeted toward efficiencies in workplaces and other activities, and they say it is likely to be embedded in most human endeavors.
The greatest share of participants in this canvassing said automated systems driven by artificial intelligence are already improving many dimensions of their work, play and home lives and they expect this to continue over the next decade. While they worry over the accompanying negatives of human-AI advances, they hope for broad changes for the better as networked, intelligent systems are revolutionizing everything, from the most pressing professional work to hundreds of the little “everyday” aspects of existence.
One respondent’s answer covered many of the improvements experts expect as machines sit alongside humans as their assistants and enhancers. An associate professor at a major university in Israel wrote, “In the coming 12 years AI will enable all sorts of professions to do their work more efficiently, especially those involving ‘saving life’: individualized medicine, policing, even warfare (where attacks will focus on disabling infrastructure and less in killing enemy combatants and civilians). In other professions, AI will enable greater individualization, e.g., education based on the needs and intellectual abilities of each pupil/student. Of course, there will be some downsides: greater unemployment in certain ‘rote’ jobs (e.g., transportation drivers, food service, robots and automation, etc.).”
