For decades, researchers have been exploring ways to harness the power of the immune system to treat cancer. One breakthrough is cell therapy, often called ‘living drugs.’ This is a form of immunotherapy that uses immune cells from a patient or a healthy donor. With advanced engineering techniques, scientists enhance these cells to recognize better and attack cancer.
“During the late 1980s and 1990s, cancer researchers started exploring ways to advance immunotherapy by transferring immune cells into a patient to attack cancer cells,” says stem cell transplant and cellular therapy specialist Hind Rafei, M.D. “They recognized that immune cells found inside tumors could help destroy cancer cells, leading to the development of one of the earliest forms of cell therapy — tumor-infiltrating lymphocytes (TILs).”
Cell therapy is a form of immunotherapy that uses immune cells from a patient or a healthy donor to treat cancer. Learn about the types of cell therapy from stem cell transplant and cellular therapy specialist Hind Rafei, M.D.
Certain DNA sequences can form structures other than the canonical double helix. These alternative DNA conformations—referred to as non-B DNA—have been implicated as regulators of cellular processes and of genome evolution, but their DNA tends to be repetitive, which until recently made reliably reading and assembling their sequences difficult.
Now, a team of researchers, led by Penn State biologists, has comprehensively predicted the location of non-B DNA structures in great apes. It’s the first step in understanding the functions and evolution of such structures, known to contribute to genetic diseases and cancer, the team said.
The work depends on newly available telomere-to-telomere (T2T), or end-to-end, genomes of humans and other great apes that overcame sequencing and assembly difficulties associated with repetitive DNA to fill in any remaining gaps in the genomes. A paper describing the study, which shows that non-B DNA is enriched in the newly sequenced segments of the genomes and suggests potential new functions, was published in the journal Nucleic Acids Research.
Patients in the early stages of psychosis respond to treatments differently than those who have developed a chronic version of the disorder. Understanding the neurobiological changes from early to chronic stages is essential for developing targeted prevention and treatment strategies. But how symptoms change during this transition—and what role the brain plays—is unclear.
Researchers at Yale School of Medicine (YSM) have now examined patients with early and chronic forms of psychosis to map symptom evolution and identify relevant brain networks. They published their findings in the journal Neuropsychopharmacology.
“We are interested in how psychosis and psychiatric disorders develop,” says Maya Foster, first author of the study and a Ph.D. student in the lab of Dustin Scheinost, Ph.D., associate professor of radiology and biomedical imaging at YSM.
Using the Australian Square Kilometer Array Pathfinder (ASKAP), astronomers have discovered 15 new giant radio galaxies with physical sizes exceeding 3 million light years. The finding was reported in a research paper published April 9 on the arXiv preprint server.
The so-called giant radio galaxies (GRGs) have an overall projected linear length exceeding at least 2.3 million light years. They are rare objects grown usually in low-density environments and display jets and lobes of synchrotron-emitting plasma. GRGs are important for astronomers studying the formation and the evolution of radio sources.
ASKAP is a 36-dish radio-interferometer operating at 700 to 1,800 MHz. It uses novel technology to achieve extremely high survey speed, making it one of the best instruments in the world for mapping the sky at radio wavelengths. Due to its large field of view, high resolution, dynamic range and good sensitivity to low-surface brightness structures, ASKAP has been essential in the search for new GRGs.
“This is a very tiny object, with very weak gravity, so it easily loses a lot of mass, which then further weakens its gravity, so it loses even more mass,” said Dr. Avi Shporer.
What can a planet that’s shedding its material teach astronomers about planetary formation and evolution? This is what a recently submitted study to The Astrophysical Journal Letters hopes to address as an international team of scientists investigated a unique exoplanet that orbits its host star approximately 20 times closer than Mercury orbits our Sun, resulting in the exoplanet shedding so much material that it’s creating a tail of debris and will eventually disintegrate into nothing.
“The extent of the tail is gargantuan, stretching up to 9 million kilometers long, or roughly half of the planet’s entire orbit,” said Dr. Marc Hon, who is a postdoc in the Kavli Institute for Astrophysics and Space Research at the Massachusetts Institute of Technology (MIT) and lead author of the study.
Exoplanet BD+054868Ab is located approximately 140 light-years from Earth and orbits its star in approximately 30.5 hours. For context, Mercury takes our Sun in 88 days. The orbit of BD+054868Ab is so close, astronomers hypothesize that it’s a molten world slowly shedding its material and they estimate it will be completely gone between 1 million and 2 million years from now. During its long and slow death, BD+054868Ab is shedding so material that it’s leaving a trail of debris in its wake, which initially puzzled astronomers after analyzing data obtained from NASA’s Transiting Exoplanet Survey Satellite (TESS).
Neutrinos, elusive fundamental particles, can act as a window into the center of a nuclear reactor, the interior of the Earth, or some of the most dynamic objects in the universe. Their tendency to change “flavors” may provide clues into the prominence of matter over antimatter in the universe or explain the existence of dark matter.
Physicists are particularly interested in proving the existence of “sterile” neutrinos. Their discovery would reveal a new form of matter that interacts only with gravity and could influence the evolution of the universe.
In a new study published in Physical Review Letters, a team of researchers from U.S. universities and national laboratories has set stringent limits on the existence and mass of sterile neutrinos. While they have yet to find the particles, they now know where not to look.
Eric Lerner is a popular science writer, plasma physicist, and long-time collaborator of the late Nobel laureate Hannes Alfvén. He’s also one of the featured speakers at our Beyond the Big Bang event this summer in Sesimbra, Portugal. For over thirty years, Lerner has been a leading voice in plasma cosmology and a critic of Big Bang cosmology, who argued for a non-expanding, steady state universe as the central claim of his landmark book The Big Bang Never Happened (affiliate link to puchase: https://amzn.to/4jEez8H). Our conversation dives into the history and foundations of plasma cosmology, from early Birkeland current experiments in the Arctic that revealed the electrical nature of the aurora, to the role of plasma dynamics in the shape and behavior of galaxies. All the hits are in here — from Halton Arp, whose Atlas of Peculiar Galaxies seriously challenged the way that mainstream cosmologists interpret redshift, to the electromagnetic forces often overlooked in mainstream cosmology, to the filamentary plasma structures and cosmic-scale currents that strain the limits of the standard model. This is a deep exploration of alternative cosmology, electric universe theories, and the scientists behind them — from Fred Hoyle to Anthony Peratt — who refused to patch a dying theory and instead asked instead if the universe might be eternal.
PARADIGM DRIFT https://demystifysci.com/paradigm-dri… Go! 00:05:59 – The Cosmological Pendulum 00:14:09 – Knowledge and Societal Progress 00:22:18 – Big Bang Origins & Ideological Influence 00:29:04 – Technological Stagnation Since the 1970s 00:32:02 – Ideology Replacing Empiricism in Science 00:36:14 – Gravity vs. Electromagnetism in Cosmology 00:41:02 – Evolution of Scientific Funding Models 00:51:11 – Birkeland Currents & Plasma Discoveries 00:56:25 – Centralization of Postwar Science 01:00:18 – Orthodoxy in Medicine 01:00:59 – Decline of Fundamental Research 01:04:39 – Plasma Cosmology vs. Dark Matter 01:08:52 – Capitalism and Research Priorities 01:14:22 – Sustaining Independent Science 01:15:16 – Birkeland, Alfvén & Plasma History 01:22:24 – Einstein’s Rise & Cultural Legacy 01:31:05 – General Relativity and Elitism 01:34:44 – Chapman’s Math vs. Empirics 01:37:12 – Alfvén’s Plasma Breakthroughs 01:43:39 – Plasma Physics vs. Big Bang Theories 01:47:39 – Nobel Prize & MHD’s Hidden Flaws 01:58:00 – Filamentary Plasmas vs. MHD 02:00:47 – Pseudoplasmas and MHD Limits 02:02:58 – Defining Plasma as a State of Matter 02:06:00 – Where Plasma Exists in Nature 02:11:17 – The Myth of Mathematical Models 02:21:10 – Scientific vs. Aesthetic Cosmology 02:29:55 – Failed Big Bang Predictions 02:36:01 – Alternatives to the Expanding Universe 02:43:09 – Large-Scale Structures and Cosmic Age 02:50:10 – Public Science and Open Debate 02:55:16 – Toward a New Cosmological Paradigm #plasma #bigbang #darkmatter #electricuniverse, #cosmology, #astrophysics, #scientificrevolution, #fusionenergy, #philosophypodcast, #sciencepodcast, #longformpodcast ABOUS US: Anastasia completed her PhD studying bioelectricity at Columbia University. When not talking to brilliant people or making movies, she spends her time painting, reading, and guiding backcountry excursions. Shilo also did his PhD at Columbia studying the elastic properties of molecular water. When he’s not in the film studio, he’s exploring sound in music. They are both freelance professors at various universities. PATREON: get episodes early + join our weekly Patron Chat https://bit.ly/3lcAasB MERCH: Rock some DemystifySci gear : https://demystifysci.myspreadshop.com… AMAZON: Do your shopping through this link: https://amzn.to/3YyoT98 DONATE: https://bit.ly/3wkPqaD SUBSTACK: https://substack.com/@UCqV4_7i9h1_V7h… BLOG: http://DemystifySci.com/blog RSS: https://anchor.fm/s/2be66934/podcast/rss MAILING LIST: https://bit.ly/3v3kz2S SOCIAL:
00:00 Go! 00:05:59 – The Cosmological Pendulum. 00:14:09 – Knowledge and Societal Progress. 00:22:18 – Big Bang Origins & Ideological Influence. 00:29:04 – Technological Stagnation Since the 1970s. 00:32:02 – Ideology Replacing Empiricism in Science. 00:36:14 – Gravity vs. Electromagnetism in Cosmology. 00:41:02 – Evolution of Scientific Funding Models. 00:51:11 – Birkeland Currents & Plasma Discoveries. 00:56:25 – Centralization of Postwar Science. 01:00:18 – Orthodoxy in Medicine. 01:00:59 – Decline of Fundamental Research. 01:04:39 – Plasma Cosmology vs. Dark Matter. 01:08:52 – Capitalism and Research Priorities. 01:14:22 – Sustaining Independent Science. 01:15:16 – Birkeland, Alfvén & Plasma History. 01:22:24 – Einstein’s Rise & Cultural Legacy. 01:31:05 – General Relativity and Elitism. 01:34:44 – Chapman’s Math vs. Empirics. 01:37:12 – Alfvén’s Plasma Breakthroughs. 01:43:39 – Plasma Physics vs. Big Bang Theories. 01:47:39 – Nobel Prize & MHD’s Hidden Flaws. 01:58:00 – Filamentary Plasmas vs. MHD 02:00:47 – Pseudoplasmas and MHD Limits. 02:02:58 – Defining Plasma as a State of Matter. 02:06:00 – Where Plasma Exists in Nature. 02:11:17 – The Myth of Mathematical Models. 02:21:10 – Scientific vs. Aesthetic Cosmology. 02:29:55 – Failed Big Bang Predictions. 02:36:01 – Alternatives to the Expanding Universe. 02:43:09 – Large-Scale Structures and Cosmic Age. 02:50:10 – Public Science and Open Debate. 02:55:16 – Toward a New Cosmological Paradigm.
A new comparison and analysis of the genomes of species in the genus Malus, which includes the domesticated apple and its wild relatives, revealed the evolutionary relationships among the species and how their genomes have evolved over the past nearly 60 million years.
The research team identified structural variations among the genomes and developed methods for identifying genes associated with desirable traits, like tastiness and resistance to disease and cold, that could help guide future apple breeding programs.
A paper describing the research, conducted by an international team that includes Penn State biologists, was published in the journal Nature Genetics.
