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Category: engineering – Page 12

For decades, creating human skin models with physiological relevance has been a persistent challenge in dermatological research. Conventional approaches, such as rodent models and two-dimensional skin cultures, fail to replicate the complexity and functionality of human skin, particularly in aspects like appendage development. These gaps hinder progress in translating laboratory findings into effective clinical treatments. The scientific community has long recognized the urgent need for advanced skin models that authentically emulate human skin’s structure and function.

On January 16, 2025, a pivotal study (DOI: 10.1093/burnst/tkae070) published in the journal Burns & Trauma made remarkable progress in skin regeneration. Researchers discovered that employing an air-liquid interface (ALI) culture method significantly enhances hair follicle formation within hiPSC-derived skin organoids compared to traditional floating culture techniques. This breakthrough holds immense potential for advancing therapies for skin disorders and crafting next-generation skin regeneration solutions.

The research employed an ALI model with transwell membranes to cultivate hiPSC-derived skin organoids (SKOs), contrasting its efficacy with conventional floating culture methods. The results were striking—SKOs under ALI conditions exhibited superior hair follicle growth, both in quantity and structural complexity. These follicles were not only larger and more mature but also demonstrated features akin to natural hair shafts, closely mirroring in vivo hair follicle development. Moreover, ALI-cultured SKOs exhibited enhanced epidermal stratification and differentiation, signifying a more precise replication of human skin architecture. These findings underscore the promise of ALI culture in advancing skin organoid engineering, offering a sophisticated and functional platform for research and therapeutic development in dermatology.

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In a pioneering approach to achieve fusion energy, the SMART device has successfully generated its first tokamak plasma. This step brings the international fusion community closer to achieving sustainable, clean, and virtually limitless energy through controlled fusion reactions.

The work is published in the journal Nuclear Fusion.

The SMART tokamak, a state-of-the-art experimental fusion device designed, constructed and operated by the Plasma Science and Fusion Technology Laboratory of the University of Seville, is a unique spherical tokamak due to its flexible shaping capabilities. SMART has been designed to demonstrate the unique physics and engineering properties of Negative Triangularity shaped plasmas towards compact fusion power plants based on Spherical Tokamaks.

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In recent years, biomedical devices have proven to be able to target also different neurological disorders. Given the rapid ageing of the population and the increase of invalidating diseases affecting the central nervous system, there is a growing demand for biomedical devices of immediate clinical use. However, to reach useful therapeutic results, these tools need a multidisciplinary approach and a continuous dialogue between neuroscience and engineering, a field that is named neuroengineering. This is because it is fundamental to understand how to read and perturb the neural code in order to produce a significant clinical outcome.

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A new stroke-healing gel created by UCLA researchers helped regrow neurons and blood vessels in mice whose brains had been damaged by strokes. The finding is reported May 21 in Nature Materials.

“We tested this in laboratory mice to determine if it would repair the brain and lead to recovery in a model of stroke,” said Dr. S. Thomas Carmichael, professor of neurology at the David Geffen School of Medicine at UCLA and co-director of the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research. “The study indicated that new brain tissue can be regenerated in what was previously just an inactive brain scar after stroke.”

The results suggest that such an approach could some day be used to treat people who have had a stroke, said Tatiana Segura, a former professor of chemical and biomolecular engineering at UCLA who collaborated on the research. Segura is now a professor at Duke University.

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Meet the Dark Matter, the groundbreaking electric motor powering Koenigsegg’s new Gemera hypercar. Officially known as the Dark Matter Raxial Flux 6-phase E-motor, this revolutionary piece of technology debuted at the 2023 Goodwood Festival of Speed. Boasting an impressive 800 horsepower and 922 lb-ft of torque, while weighing just 40kg, the Dark Matter is hailed as the world’s most powerful automotive-grade electric motor. With its unique six-phase technology, it marks a major leap forward in electric vehicle engineering, surpassing the three-phase motors commonly used in most electric vehicles today.

The Dark Matter electric motor is considered the world’s most powerful automotive-grade motor, using a unique six-phase technology. This motor is a significant improvement over the three-phase motors commonly used in most electric vehicles today. The Dark Matter replaces the previous motor used in the Gemera, called the Quark.

Both the Quark and the Dark Matter are “raxial flux” motors, which combine features of two common types of electric motors: radial flux and axial flux. Radial flux motors offer more power but less torque, while axial flux motors are known for providing high torque but with less power. The key difference between these two designs is how the magnetic field travels through the motor. In a radial flux motor, the magnetic field path is longer, creating more power. In an axial flux motor, the magnetic field follows a shorter, more direct path, giving the motor more torque.

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A joint research team from Hefei Institutes of Physical Science of the Chinese Academy of Sciences has successfully developed a continuous cryogenic pellet injection system for tokamak fueling. This innovative system addresses key technical challenges associated with cryogenic ice formation, pellet cutting, and launching.

Cryogenic pellet injection is a state-of-the-art technique in fusion research. It involves condensing hydrogen isotopic gases into solid ice pellets, which are then accelerated and injected into plasma. This method allows for deep particle and high fueling efficiency, making it crucial for the future of fusion reactors.

It is recognized as a critical fueling technology for next-generation fusion devices, including the International Thermonuclear Experimental Reactor (ITER), the China Fusion Engineering Test Reactor (CFETR), and the European Demonstration Fusion Reactor (EU-DEMO).

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How can computer models help medical professionals combat antibiotic resistance? This is what a recent study published in PLOS Biology hopes to address as a team of researchers from the University of Virginia (UVA) developed computer models that can be used to target specific genes in bacteria to combat antimicrobial resistant (AMR) bacteria. This study has the potential to help scientists, medical professionals, and the public better understand innovative methods that can be used to combat AMR with bacterial diseases constantly posing a risk to global human health.

For the study, the researchers used computer models to produce an assemblage of genome-scale metabolic network reconstructions (GENREs) diseases to identify key genes in stomach diseases that can be targeted with antibiotics to circumvent AMR in these bacterial diseases. The researchers validated their findings with laboratory experiments involving microbial samples and found that a specific gene was responsible for producing stomach diseases, thus strengthening the argument for using targeted antibiotics to combat AMR.

“Using our computer models we found that the bacteria living in the stomach had unique properties,” said Emma Glass, who is a PhD Candidate in Biomedical Engineering at UVA and lead author of the study. “These properties can be used to guide design of targeted antibiotics, which could hopefully one day slow the emergence of resistant infections.”

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