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This study aimed to explore whether the therapeutic effects of EPO rely on the suppression of the NLRP3 inflammasome and the specific mechanisms in an LPS-induced ALI mouse model. ALI was induced in C57BL/6 mice by intraperitoneal (i.p.) injection of LPS (15 mg/kg). EPO was administered intraperitoneally at 5 U/g after LPS challenge. The mice were sacrificed 8 h later. Our findings indicated that application of EPO markedly diminished LPS-induced lung injury by restoring histopathological changes, lessened lung wet/dry (W/D) ratio, protein concentrations in bronchoalveolar lavage fluid (BALF) and myeloperoxidase (MPO) levels. Meanwhile, EPO evidently decreased interleukin-1β (IL-1β) and interleukin-18 (IL-18) secretion, the expression of NLRP3 inflammasome components including pro-IL-1β, NLRP3, and cleaved caspase-1 as well as phosphorylation of nuclear factor-κB (NF-κB) p65, which may be associated with activation of EPO receptor (EPOR), phosphorylation of Janus-tyrosine kinase 2 (JAK2) and signal transducer and activator of transcription 3 (STAT3)

Taken together, this study indicates that EPO can effectively attenuate LPS-induced lung injury in mice by suppressing the NLRP3 inflammasome, which is dependent upon activation of EPOR/JAK2/STAT3 signaling and inhibition of the NF-κB pathway.

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If you have not seen these useless boxes, this one is the best so far! • Credit: @worldofartists • Via fxhm (youtube)… #engineer #funny #artistic #makingfactory #designer #invention #makersgonnamake #sandiego #electronics

Samsung Electronics today announced it will be introducing the first DRAM memory modules in the industry designed with cutting-edge Extreme Ultraviolet Technology (EUV).

One of the world’s leading memory manufacturers, Samsung says that response to a million evaluation units of its first line of 10nm-class DDR4 DRAM modules has been positive and that it will soon begin processing orders for worldwide distribution.

EUV technology allows memory modules to be manufactured more accurately and more quickly. It speeds up the lithography process by reducing the number of repetitive steps and facilitates the production of complex chip patterns. It means greater performance accuracy and a shortened development time.

Apps went undetected by Google and antivirus scanners.

Apple’s latest iPad — the iPad Pro — is its most-powerful and comes with several first-time features. This is the first iPad with a a dual-camera, a trackpad, a Magic keyboard and LiDAR scanner. It is the most-powerful iPad Apple has made and is set to give tough competition to a lot of Windows-powered laptops. Here are 15 things you should know about the new iPad Pro:

This could used to emp laser missiles or other targets.

The electromagnetic pulses (EMPs) generated during the interaction of a focused 1.315-μm sub-nanosecond laser pulse with a solid hydrogen ribbon were measured. The strength and temporal characteristics of EMPs were found to be dependent on the target density. If a low density target is ionized during the interaction with the laser, and the plasma does not physically touch the target holder, the EMP is weaker in strength and shorter in time duration. It is shown that during the H₂ target experiment, the EMP does not strongly affect the response of fast electronic devices. The measurements of the EMP were carried out by Rohde&Schwarz B-Probes, particularly sensitive in the frequency range from 30 MHz and 1 GHz. Numerical simulations of resonant frequencies of the target chamber used in the experiment at the Prague Asterix Laser System kJ-class laser facility elucidate the peaked structure of EMP frequency spectra in the GHz domain.

https://youtube.com/watch?v=QKi5T4uTGXk

Check your blood glucose without fingersticks using the FreeStyle Libre System, a continuous glucose monitoring system that includes a sensor and reader.

You don’t need a big laser to make laser-induced graphene (LIG). Scientists at Rice University, the University of Tennessee, Knoxville (UT Knoxville) and Oak Ridge National Laboratory (ORNL) are using a very small visible beam to burn the foamy form of carbon into microscopic patterns.

Scientists record the formation of foamy laser-induced graphene made with a small laser mounted to a scanning electron microscope. The reduced size of the conductive material may make it more useful for flexible electronics.

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