Lifeboat Foundation

“The furin cleavage site consists of four amino acids PRRA, which are encoded by 12 inserted nucleotides in the S gene. A characteristic feature of this site is an arginine doublet. This insertion could have occurred by random insertion mutation, recombination or by laboratory insertion. The researchers say the possibility of random insertion is too low to explain the origin of this motif. Surprisingly, the CGGCGG codons encoding the two arginines of the doublet in SARS-CoV-2 are not found in any of the furin sites in other viral proteins expressed by a wide range of viruses. Even within the SARS-CoV-2, where arginine is encoded by six codons, only a minority of arginine residues are encoded by the CGG codon. Again, only two of the 42 arginines in the SARS-CoV-2 spike are encoded by this codon — and these are in the PRRA motif. For recombination to occur, there must be a donor, from another furin site and probably from another virus. In the absence of a known virus containing this arginine doublet encoded by the CGGCGG codons, the researchers discount the recombination theory as the mechanism underlying the emergence of PRRA in SARS-CoV-2.”

The ongoing pandemic of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has largely defied attempts to contain its spread by non-pharmaceutical interventions (NPIs). With the massive loss of life and economic damage, the only way out, in the absence of specific antiviral therapeutics, has been the development of vaccines to achieve population immunity.

A new study on the Preprints server discusses the origin of the furin cleavage site on the SARS-CoV-2 spike protein, which is responsible for the virus’s relatively high infectivity compared to relatives in the betacoronavirus subgenus.

Continue reading “The origin of SARS-CoV-2 furin cleavage site remains a mystery” »

https://youtube.com/watch?v=m0vWME0Mk1Q

By 2050, the number of adults over the age of 65 globally will double, reaching a staggering 1.6 billion, with the largest growth in the developing world. This growth will be one of the greatest social, economic, and political transformations of our time, that will impact existing healthcare, government and social systems, that today are largely not inclusive of the ageing population or built to the scale needed to support it.

But we can begin to make investments in our support systems (enabled and scaled by technology) that encompass a coordinated response from governments, society, academia, and the private sector.

Continue reading “Ageing: Looming crisis or booming opportunity?” »

# **A $3.5 Trillions Space Economy in 2040**

The first session of the GALIX Cyber-conference, that took place today, and I was in the panel, together with Michelle Hanlon (ForAllMoonkind), Madhu Thangavelu (Moon Village Association), Alicia Woodly (AXIOM). The panel was excellently chaired by Jean-Jacques Tortora (ESPI).

TOWARDS a METAMATERIALLY-BASED ANALOGUE SENSOR FOR TELESCOPE EYEPIECES jeremy batterson.

https://www.youtube.com/watch?v=rVQWmWkbzkw.

(NB: Those familiar with photography or telescopy can skip over the “elements of a system,” since they will already know this.)

Continue reading “Navy engineer devises new way to enhance night vision for ground forces” »

Advocates contend central bank digital currencies can make cross-border transactions easier, promote financial inclusion and provide payment system stability. There are also privacy and surveillance risks with government-issued digital currencies. And in times of economic uncertainty, people may be more likely to pull their funds from commercial banks, accelerating a bank run.

Intense interest in cryptocurrencies and the Covid-19 pandemic have sparked debate among central banks on whether they should issue digital currencies of their own.

China has been in the lead in developing its own digital currency. It’s been working on the initiative since 2014. Chinese central bank officials have already conducted massive trials in major cities including Shenzhen, Chengdu and Hangzhou.

Continue reading “Central banks around the world want to get into digital currencies—here’s why” »

SACRAMENTO, Calif. (AP) — After getting $500 per month for two years without rules on how to spend it, 125 people in California paid off debt, got full-time jobs and had “statistically significant improvements” in emotional health, according to a study released Wednesday.

The program was the nation’s highest-profile experiment in decades of universal basic income, an idea that was revived as a major part of Andrew Yang’s 2020 campaign for president.

Continue reading “Employment rose among those in free money experiment, study shows” »

The money committed to companies and projects in this area increased to $13.8 billion, more than 4.5 times that invested in 2019, according to the Artificial Intelligence Index, an annual report produced under the auspices of Stanford University’s Institute for Human-Centered Artificial Intelligence (HAI).

Those are a few of the insights from this year’s AI Index report, which shows adoption of the pandemic did nothing to dent adoption of the technology.

Critics of renewable energy often cite two reasons for why they think a transition from fossil fuels will take half a century. Firstly, that sources of renewable energy are too intermittent to be reliable and secondly, that governments cannot bear the costs of switching entire economies to clean energy.

National Academies study says fusion can help decarbonize US energy, calls for public-private approach to pilot plant operation by 2035–40.

Electricity generated by fusion power plants could play an important role in decarbonizing the U.S. energy sector by mid-century, says a new consensus study report from the National Academies of Sciences, Engineering, and Medicine, which also lays out for the first time a set of technical, economic, and regulatory standards and a timeline for a U.S. fusion pilot plant that would begin producing energy in the 2035–40 time frame.

To achieve this key step toward commercialization, the report calls for an aggressive public-private effort to produce by 2028 a pilot plant design that can, when built, accommodate any of the developmental approaches seeking to realize fusion’s potential as a safe, carbon-free, on-demand energy source.