“The point being, science needs room to figure out exactly what this technology is capable of doing. Right now, researchers have a ton of potential on their hands, but not a lot of agreement about how far that potential reaches.” Read more
By David Cyranoski — Scientific American
In a Comment published on March 12 in Nature, Edward Lanphier, chairman of the Alliance for Regenerative Medicine in Washington DC, and four co-authors call on scientists to agree not to modify human embryos — even for research.
“Such research could be exploited for non-therapeutic modifications. We are concerned that a public outcry about such an ethical breach could hinder a promising area of therapeutic development,” write Lanphier and his colleagues, who include Fyodor Urnov, a pioneer in gene-editing techniques and scientist at Sangamo BioSciences in Richmond, California. Many groups, including Urnov’s company, are already using gene-editing tools to develop therapies that correct genetic defects in people (such as by editing white blood cells). They fear that attempts to produce ‘designer babies’ by applying the methods to embryos will create a backlash against all use of the technology.Read more
By Antonio Regalado — MIT Technology Review
If anyone had devised a way to create a genetically engineered baby, I figured George Church would know about it.
At his labyrinthine laboratory on the Harvard Medical School campus, you can find researchers giving E. Coli a novel genetic code never seen in nature. Around another bend, others are carrying out a plan to use DNA engineering to resurrect the woolly mammoth. His lab, Church likes to say, is the center of a new technological genesis—one in which man rebuilds creation to suit himself.
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Posted By Regan Penaluna — Nautilus
When we talk about genes, we often use expressions inherited from a few influential geneticists and evolutionary biologists, including Francis Crick, James Watson, and Richard Dawkins. These expressions depict DNA as a kind of code telling bodies how to form. We speak about genes similarly to how we speak about language, as symbolic and imbued with meaning. There is “gene-editing,” and there are “translation tables” for decoding sequences of nucleic acid. When DNA replicates, it is said to “transcribe” itself. We speak about a message—such as, build a tiger! or construct a female!—being communicated between microscopic materials. But this view of DNA has come with a price, argue some thinkers. It is philosophically misguided, they say, and has even led to scientific blunders. Scratch the surface of this idea, and below you’ll find a key contradiction.
Since the earliest days of molecular biology, scientists describe genetic material to be unlike all other biological material, because it supposedly carries something that more workaday molecules don’t: information. In a 1958 paper, Crick presented his ideas on the importance of proteins for inheritance, and said that they were composed of energy, matter, and information. Watson called DNA the “repository” of information.
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By Jason Dorrier — Singularity Hub
The blueprint of every living thing on the planet is encoded in DNA. We know the stuff can hold a lot of information. But how much is a lot? We could theoretically encode the world’s data (from emails to albums, movies to novels) on just a few grams of DNA. DNA already preserves life itself—now it might also preserve life as we live it.
According to New Scientist, a gram of DNA could theoretically store 455 exabytes of data. And Quartz drives the point home. If the world has about 1.8 zettabytes of data, according to a 2011 estimate, all the world’s information would fit on a four-gram DNA hard drive the size of a teaspoon.
Helen Knight | MIT News correspondent
The sequencing of the human genome laid the foundation for the study of genetic variation and its links to a wide range of diseases. But the genome itself is only part of the story, as genes can be switched on and off by a range of chemical modifications, known as “epigenetic marks.”
Now, a decade after the human genome was sequenced, the National Institutes of Health’s Roadmap Epigenomics Consortium has created a similar map of the human epigenome.
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Quoted: “Legendary cyberculture icon (and iconoclast) R.U. Sirius and Jay Cornell have written a delicious funcyclopedia of the Singularity, transhumanism, and radical futurism, just published on January 1.” And: “The book, “Transcendence – The Disinformation Encyclopedia of Transhumanism and the Singularity,” is a collection of alphabetically-ordered short chapters about artificial intelligence, cognitive science, genomics, information technology, nanotechnology, neuroscience, space exploration, synthetic biology, robotics, and virtual worlds. Entries range from Cloning and Cyborg Feminism to Designer Babies and Memory-Editing Drugs.” And: “If you are young and don’t remember the 1980s you should know that, before Wired magazine, the cyberculture magazine Mondo 2000 edited by R.U. Sirius covered dangerous hacking, new media and cyberpunk topics such as virtual reality and smart drugs, with an anarchic and subversive slant. As it often happens the more sedate Wired, a watered-down later version of Mondo 2000, was much more successful and went mainstream.”
Read the article here >https://hacked.com/irreverent-singularity-funcyclopedia-mondo-2000s-r-u-sirius/
Western Canada’s most futurist-oriented longevity organization, the Lifespan Society of British Columbia, has organized a first-class life extension conference, which will take place later this fall in the heart of downtown Vancouver. The Longevity and Genetics Conference 2014 offers a full-day of expert presentations, made accessible to a general audience, with keynote on the latest developments in biorejuvination by Aubrey de Grey of SENS Research Foundation. The conference will be interactive, with a panel session for audience questions, and VIP options for further interaction with speakers.
Aubrey de Grey
Who will be there? In addition to Aubrey de Grey, there are four other speakers confirmed thus far: Dr. Angela Brooks-Wilson, Head of Cancer Genetics at the Michael Smith Genome Sciences Centre at the BC Cancer Agency, Dr. S. Jay Olshansky, Board of Directors of the American Federation of Aging Research, and co-author of The Quest for Immortality: Science at the Frontiers of Aging, Dr. Clinton Mielke, former Mayo Clinic researcher and founder of the quantified self platform “infino.me”, and lastly, one of futurism’s most experienced and dedicated radical longevity advocates, Benjamin Best, who is currently Director of Research Oversight at the Life Extension Foundation. This conference is a multi-disciplinary event, engaging several points of interest and relevance in the longevity space, from the cellular, genetic science of aging, to the latest epidemiological and even demographic research. You can also expect discussion on personalized medicine and quantified self technologies, as well as big picture, sociological and philosophical, longevity-specific topics.
All around, the 2014 Longevity and Genetics conference, set to take place Saturday November 15, has a lot to offer, as does the host city of Vancouver. A recent study has indicated that a majority of Canadians, 59%, are in favor of life extension technology, with 47% expecting that science and technology will enable living until 120 by 2050. The Lifespan Society of British Columbia is keeping that momentum and enthusiasm alive and growing, and I’m glad they have organized such a high-calliber event. Tickets are currently still available. Learn more about the event and purchase tickets here.
Continue reading “2014 Longevity and Genetics Conference – Keynote Aubrey de Grey” »
In what appears to be the first study of its kind, computer scientists report that an algorithm discovered more than 50 years ago in game theory and now widely used in machine learning is mathematically identical to the equations used to describe the distribution of genes within a population of organisms. Researchers may be able to use the algorithm, which is surprisingly simple and powerful, to better understand how natural selection works and how populations maintain their genetic diversity.
By viewing evolution as a repeated game, in which individual players, in this case genes, try to find a strategy that creates the fittest population, researchers found that evolution values both diversity and fitness.
Written By: Jason Dorrier — Singularity Hub
In his latest video, host of National Geographic’s Brain Games and techno-poet, Jason Silva, explores the universe’s tendency to self-organize. Biology, he says, seems to have agency and directionality toward greater complexity, and humans are the peak.
“It’s like human beings seem to be the cutting edge,” Silva says. “The evolutionary pinnacle of self-awareness becoming aware of its becoming.”
