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In this episode, Max and Daniel sit down with the renowned Aubrey de Grey to discuss the connection between life extension and cryonics. They cover a wide range of topics, diving into the latest breakthroughs and obstacles in both fields.

In this captivating conversation, they explore:

-The current state of rejuvenation technologies.
–Recent advances in longevity research over the past decade.
–Challenges still facing life extension science.
–Perspectives on achieving longevity escape velocity.
–Progress in robust mouse rejuvenation experiments.
–Aubrey de Grey’s journey into the world of cryonics.
–Tanya Jones’s new cryonics venture, Keinice.
–Innovative cryopreservation techniques using helium persufflation.
–The importance of cryonics vs life extension.
–The potential for cryonics to become mainstream.
–The search for major donors to support cryonics research.
–And much more!

As always, you can find Max and Daniel over at the Cryosphere Cryonics discord server: https://discord.gg/cryosphere.

You can listen to the audio only version at our website or any of your favorite podcast apps:
https://www.cryonicsunderground.com/1510453/12638348-aubrey-…-extension.

Visit Aubrey’s new organization The Longevity Escape Velocity Foundation https://www.levf.org/

The Death of Death is an international bestseller by José Cordeiro and David Wood that claims that “death will be optional by 2045” – or even earlier, if more public and private funds are invested in rejuvenation technologies.

Longevity. Technology: Already available in more than 10 languages, the book provides insight into recent exponential advances in AI, tissue regeneration, stem cell treatment, organ printing, cryopreservation and genetic therapies that, say the authors, offer a realistic chance to solve the problem of the aging of the human body for the first time in human history. In fact, the book’s subtitle is The Scientific Possibility of Physical Immortality and its Moral Defense.

Given that until relatively recently, just mentioning the concept of ‘biological immortality’ was enough to raise eyebrows and with most of the opinion that it should be filed away under ‘science fiction’ or ‘charlatanism’. However, longevity science is advancing at an incredible pace and today there are people who no longer wonder if immortality is possible, but when it will be a reality. We sat down with José Luis Corderio PhD to find out more.

YOU’RE INVITED! — OPEN TO CI MEMBERS, NON-MEMBERS AND THE GENERAL PUBLIC2023 Cryonics Institute Annual General MeetingSUNDAY — SEPT 10, 2023AGM Location: Infinity Hall & Sidebar 16,650 E 14 Mile RoadFraser, MI 48026phone: 586–879-6157website: infinityhallsidebar.com2023 AGM DetailsSunday, September 10, 2023Event start time: 3:00 pm Eastern TimeEvent end time: 6:30 pmFacility ToursTours of the Main and new […].

In Switzerland, there’s a new cryonics company: and they invited me to have a look around. I had questions: legal, practical, and ethical, and I want to be clear: this is not an endorsement. I just wasn’t going to turn down that invitation. ■ Tomorrow Bio: https://www.tomorrow.bio/

Camera: Martin Bäbler.

I’m at https://tomscott.com.
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and on Instagram as tomscottgo.

Stem cells (SCs) are undifferentiated cells which can proliferate indefinitely or differentiate into progenitor cells and end-phase differentiated cells (becoming pluripotent) (Mayo, 2021; Slack, 2022). Human embryonic SCs (hE-SCs) are found in the inner cell mass of the blastocyst; h E-SC research raises ethical concerns (Lo and Parham, 2009), and h E-SC transplantation in vivo can lead to the formation of large tumors called teratomas (Blum and Benvenisty, 2008).

Small numbers of adult SCs are found in some organ “niches”, including the bone marrow, where hematopoietic progenitor cells (HPC) replenish blood and immune cells. In 1958, Mathe et al. (1959) successfully performed the first adult SC therapy on five workers who had received high-dose accidental irradiation at the Vinca Nuclear Institute in Yugoslavia. After transfusions and grafts of homologous adult bone marrow, all workers survived (Mathe et al., 1959).

For years, the human umbilical cord was a waste material and, unlike h E-SCs, its use does not raise ethical concerns. In 1988, Gluckman et al. (1989) successfully performed the first human cord blood transplant in a child with Fanconi’s anemia. Since then, numerous public and private cord blood banks have been established worldwide for the cryopreservation of cord blood in view of its transplantation (Gluckman, 2011).