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Category: chemistry – Page 90

First electrically pumped, continuous-wave semiconductor laser advances silicon photonics integration

Scientists have developed the first electrically pumped continuous-wave semiconductor laser composed exclusively of elements from the fourth group of the periodic table—the “silicon group.”

Built from stacked ultrathin layers of germanium-tin and germanium-tin, this new laser is the first of its kind directly grown on a silicon wafer, opening up new possibilities for on-chip integrated photonics. The findings have been published in Nature Communications. The team includes researchers from Forschungszentrum Jülich, FZJ, the University of Stuttgart, and the Leibniz Institute for High Performance Microelectronics (IHP), together with their French partner CEA-Leti.

The rapid growth of artificial intelligence and the Internet of Things are driving the demand for increasingly powerful, energy-efficient hardware. Optical data transmission, with its ability to transfer vast amounts of data while minimizing , is already the preferred method for distances above 1 meter and is proving advantageous even for shorter distances. This development points towards future microchips featuring low-cost photonic integrated circuits (PICs), offering significant cost savings and improved performance.

Shape-changing device helps visually impaired people perform location task as well as sighted people

Water electrolysis is a cornerstone of global sustainable and renewable energy systems, facilitating the production of hydrogen fuel. This clean and versatile energy carrier can be utilized in various applications, such as chemical CO2 conversion, and electricity generation. Utilizing renewable energy sources such as solar and wind to power the electrolysis process may help reduce carbon emissions and promote the transition to a low-carbon economy.

The development of efficient and stable anode materials for the Oxygen Evolution Reaction (OER) is essential for advancing Proton Exchange Membrane (PEM) water electrolysis technology. OER is a key electrochemical reaction that generates oxygen gas (O₂) from water (H₂O) or hydroxide ions (OH⁻) during water splitting.

This seemingly simple reaction is crucial in energy conversion technologies like as it is hard to efficiently realize and a concurrent process to the wanted hydrogen production. Iridium (Ir)-based materials, particularly amorphous hydrous oxide (am-hydr-IrOx), are at the forefront of this research due to their high activity. However, their application is limited by high dissolution rates of the precious iridium.

Novel technique uses magnetic fields to probe long-term aging in batteries

Researchers at the U.S. Department of Energy’s (DOE) Argonne National Laboratory have developed and demonstrated an innovative set of methods to evaluate long-term aging in real-world battery cells. The methods, described in a recent paper, are based on a phenomenon called nuclear magnetic resonance (NMR), commonly used in medical imaging. This is the first-ever NMRspectroscopy capability that can track in fine detail how the chemistry of commercial pouch battery cells evolves over years of operation.

Argonne develops a novel method that uses nuclear magnetic resonance spectroscopy to characterize the chemical evolution inside battery cells over years of operation.

Reducing Risk of Opioid Addiction While Alleviating Pain

Increasing the levels of chemicals naturally produced in the body called endocannabinoids may thwart the highly addictive nature of opioids such as morphine and oxycodone while maintaining the drugs’ ability to relieve pain, according to Weill Cornell Medicine investigators working with researchers from The Center for Youth Mental Health at NewYork-Presbyterian. Endocannabinoids bind to cannabinoid receptors throughout the body that regulate activities, such as learning and memory, emotions, sleep, immune response and appetite.

Opioids prescribed to control pain can become addictive because they not only dull pain, but also produce a sense of euphoria. The preclinical study, published Nov. 29 in Science Advances, may lead to a new type of therapeutic that could be taken with an opioid regimen to only reduce the rewarding aspect of opioids.

In 2023, opioid abuse or overuse was responsible for more than 80,000 deaths, fueling a national crisis, according to the U.S. Centers for Disease Control and Prevention. Illegal recreational drugs were ultimately responsible for many deaths, but not all of them. “When someone has surgery and is taking opioids for pain management, there’s always a risk of developing a dependence on these drugs,” said senior author Dr. Francis Lee, chair of the Department of Psychiatry at Weill Cornell Medicine and psychiatrist-in-chief at New York-Presbyterian/Weill Cornell Medical Center.

AI-powered tutor, teaching assistant tested as a way to help educators and students

We are about to show you a technological innovation that could, one day, change the way every child in every school in America is taught. It’s an online tutor powered by artificial intelligence designed to help teachers be more efficient… and students learn more effectively. It’s called Khanmigo–conmigo means “with me,” in Spanish. And Khan…is its creator…Sal Khan, the well-known founder of Khan Academy — whose lectures and educational software have been used for years by tens of millions of students and teachers in the U.S. and around the world. Khanmigo was built with the help of OpenAI, the creator of ChatGPT. Its potential is staggering, but it’s still very much a work in progress. It’s being piloted in 266 school districts in the U.S. in grades three-12. We went to Hobart High School in Indiana to see how it works.

Melissa Higgason: Good morning, just a normal day in chem, right?

At eight in the morning Melissa Higgason knows it’s not always easy to get 30 high schoolers excited about chemistry.

Decoding protein interactions to better understand how mutations contribute to disease

Investigating how proteins interact is key to understanding how cells work and communicate. In a new study published in Nature Communications, FMI researchers have provided key insights into how protein interactions are governed and how mutations influence cellular functions.

Proteins are the molecular machines of life, performing tasks ranging from driving to orchestrating cell communication. For these tasks, proteins must bind to the right partners with precision, avoiding mispairings that could disrupt cellular processes and lead to disease.

Scientists have long been curious about how changes in the —the building blocks of proteins—can alter a protein’s binding capabilities. To investigate this question, researchers in the Diss lab analyzed the effects of all possible mutations in a single protein across its with an entire family of partner proteins. They focused on a protein called JUN, which plays a key role in DNA binding and cellular communication.

Less is more: Why an economical iridium catalyst works so well

Iridium-based catalysts are needed to produce hydrogen using water electrolysis. Now, a team at HZB has shown that the newly developed P2X catalyst, which requires only a quarter of the iridium, is as efficient and stable over time as the best commercial catalyst. Measurements at BESSY II have now revealed how the special chemical environment in the P2X catalyst during electrolysis promotes the oxygen evolution reaction during water splitting.

In the future, hydrogen will be needed in a climate-neutral energy system to store energy, as a fuel, and a raw material for the chemical industry. Ideally, it should be produced in a climate-neutral way, using electricity generated from harnessing the sun’s or wind energy, via the electrolysis of water.

In that respect, Proton Exchange Membrane Water Electrolysis (PEM-WE) is currently considered a key technology. Both electrodes are coated with special electrocatalysts to accelerate the desired reaction. Iridium-based catalysts are best suited for the anode, where the sluggish oxygen evolution reaction occurs. However, iridium is one of the rarest elements on earth, and one of the major challenges is to significantly reduce the demand for this precious metal.

Network-based analyses uncover how neuroinflammation-causing microglia in Alzheimer’s disease form

Cleveland Clinic Genome Center researchers have unraveled how immune cells called microglia can transform and drive harmful processes like neuroinflammation in Alzheimer’s disease. The study, published in the journal Alzheimer’s & Dementia, also integrates drug databases with real-world patient data to identify FDA-approved drugs that may be repurposed to target disease-associated microglia in Alzheimer’s disease without affecting the healthy type.

The researchers, led by study corresponding author Feixiong Cheng, Ph.D., hope their unique approach of integrating genetic, chemical and human health data to identify and corresponding drugs will inspire other scientists to take similar approaches in their own research.

Microglia are specialized that patrol our brains, seeking and responding to tissue damage and external threats like bacteria and viruses. Different types of microglial cells use different methods to keep the brain safe. Some may cause neuroinflammation—inflammation in the brain—to fight invaders or kickstart the repair process in damaged cells. Others may work to “eat” dangerous substances in the brain, and clean up damage and debris. However, during Alzheimer’s disease, new types of microglia can form that promote .

Senescence cell signature associated with poor prognosis, epithelial–mesenchymal transition, solid histology, and spread through air spaces in lung adenocarcinoma

📢New in GeroScience by Springer Nature.

Senescence cell signature associated with poor prognosis, epithelial–mesenchymalion, solid histology, and spread through air spaces in lung adenocarcinoma by Young Wha Koh, Jae-Ho Han, Seokjin Haam & Hyun Woo Lee.

Cellular senescence is involved in critical processes in tumor progression. Despite this potential relationship, the relationship between tumor cell senescence, prognostic significance, spread through air spaces (STAS), and tumor histology has not been investigated in lung adenocarcinoma (LUAD). We used the LUAD PanCancer Atlas dataset to assess senescence cell signature (SCS) based on the SenMayo gene set. We examined the relationship between SCS, prognostic significance, STAS, and tumor histology. This relationship was confirmed in independent LUAD datasets by validation using immunohistochemical senescence markers. In the LUAD PanCancer Atlas dataset, patients with high SCS expression had a higher prevalence of solid histology and STAS patterns than those with low SCS expression.

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