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Category: chemistry – Page 323

Dr. Jonathan Chernoff, MD, PhD — Senior VP, Deputy Director, and CSO — Fox Chase Cancer Center

Innovating At The Frontiers Of Cancer Biology — Dr. Jonathan Chernoff MD, PhD, Senior Vice President, Deputy Director, and Chief Scientific Officer, Fox Chase Cancer Center.

Dr. Jonathan Chernoff, MD, PhD, is Senior Vice President, Deputy Director, and Chief Scientific Officer, at Fox Chase Cancer Center (https://www.foxchase.org/) where he coordinates and charts the future course of research for the organization.

The Hospital of Fox Chase Cancer Center and its affiliates (collectively “Fox Chase Cancer Center”), a member of the Temple University Health System, is one of the leading cancer research and treatment centers in the United States. Founded in 1904 in Philadelphia as one of the nation’s first cancer hospitals, Fox Chase was also among the first institutions to be designated a National Cancer Institute Comprehensive Cancer Center in 1974.

Dr. Chernoff joined the staff in 1991 as an associate member and was promoted to member with tenure in 1996. In 2002 he was promoted to be a senior member in Fox Chase Cancer Center’s Basic Science division, the equivalent of a full professor in a university.

A molecular oncologist as well as a board-certified medical oncologist, Dr. Chernoff has a special interest in factors that control cell growth and movement, including oncogenes and anticancer or tumor-suppressor genes, and has made fundamental contributions in this research.

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The number of neurons in Drosophila and mosquito brains

Various insect species serve as valuable model systems for investigating the cellular and molecular mechanisms by which a brain controls sophisticated behaviors. In particular, the nervous system of Drosophila melanogaster has been extensively studied, yet experiments aimed at determining the number of neurons in the Drosophila brain are surprisingly lacking. Using isotropic fractionator coupled with immunohistochemistry, we counted the total number of neuronal and non-neuronal cells in the whole brain, central brain, and optic lobe of Drosophila melanogaster. For comparison, we also counted neuronal populations in three divergent mosquito species: Aedes aegypti, Anopheles coluzzii and Culex quinquefasciatus. The average number of neurons in a whole adult brain was determined to be 199380 ±3400 cells in D. melanogaster, 217910 ±6180 cells in Ae. aegypti, 223020 ± 4650 cells in An. coluzzii and 225911±7220 cells in C. quinquefasciatus. The mean neuronal cell count in the central brain vs. optic lobes for D. melanogaster (101140 ±3650 vs. 107270 ± 2720), Ae. aegypti (109140 ± 3550 vs. 112000 ± 4280), An. coluzzii (105130 ± 3670 vs. 107140 ± 3090), and C. quinquefasciatus (108530 ±7990 vs. 110670 ± 3950) was also estimated. Each insect brain was comprised of 89% ± 2% neurons out of its total cell population. Isotropic fractionation analyses did not identify obvious sexual dimorphism in the neuronal and non-neuronal cell population of these insects. Our study provides experimental evidence for the total number of neurons in Drosophila and mosquito brains.

Citation: Raji JI, Potter CJ (2021) The number of neurons in Drosophila and mosquito brains. PLoS ONE 16: e0250381. https://doi.org/10.1371/journal.pone.

Editor: Matthieu Louis, University of California Santa Barbara, UNITED STATES.

Resetting the biological clock

The biological clock is present in almost all cells of an organism. As more and more evidence emerges that clocks in certain organs could be out of sync, there is a need to investigate and reset these clocks locally. Scientists from the Netherlands and Japan introduced a light-controlled on/off switch to a kinase inhibitor, which affects clock function. This gives them control of the biological clock in cultured cells and explanted tissue. They published their results on 26 May in Nature Communications.

Life on Earth has evolved under a 24-hour cycle of light and dark, hot and cold. “As a result, our cells are synchronized to these 24-hour oscillations,” says Wiktor Szymanski, Professor of Radiological Chemistry at the University Medical Center Groningen. Our circadian clock is regulated by a central controller in the , a region in the brain directly above the optic nerve, but all our cells contain a clock of their own. These clocks consist of an oscillation in the production and breakdown of certain proteins.

Scientists Discover a New Type of Biochemical That Could Be in All Life on Earth

The wonderful mess of molecules that make up living things is so complex, biologists have overlooked an entire class of them – until now. This missed bit of biochemistry is neither rare nor hard to find; it’s just no one had thought to look for it before.

“This is a stunning discovery of an entirely new class of biomolecules,” said Stanford biochemist Carolyn Bertozzi.

“It’s really a bombshell because the discovery suggests that there are biomolecular pathways in the cell that are completely unknown to us.”

Scientists find ultraviolet light may create life-essential chemicals

Circa 2016 o.o!

The theory used to be that hydrocarbons were created in “shocks,” or violent stellar events that cause a lot of turbulence and, with the shock waves, make atoms into ions, which are more likely to combine.

The data from the European Space Agency’s Herschel Space Observatory has since proved that theory wrong. Scientists at Herschel studied the components in the Orion Nebula, mapping the amount, temperature and motions for the carbon-hydrogen molecule (CH), the carbon-hydrogen positive ion (CH+) and their parent molecule: the carbon ion (C+).

They found that in Orion, CH+ is emitting light instead of absorbing it, which means that it is warmer than the background gas. This was surprising to scientists because the CH+ molecule is incredibly reactive and needs a high amount of energy to form, so when it interacts with the background hydrogen in the cloud it gets destroyed.

Eternally five years away? No, batteries are improving under your nose

Researchers have also long been chasing lithium-air batteries that could realize a huge jump in energy density. And beyond lithium, there are other entirely different chemistries in development out there. At some point, one of them should click for one application or another.

Lithium-ion or not, an explosion of grid-scale battery installations is coming as prices continue to fall. The nascent art of lithium-ion battery recycling is also sure to mature and expand, improving the sustainability of these batteries by recovering and resetting their chemical building blocks.

Adopt cold-fusion-like skepticism of any of these future-looking statements as you please, but today’s batteries aren’t those of 20 or even 10 years ago. The same thing is bound to be true in another 10 years—even if that progress doesn’t come in a single, giant leap with global fanfare.

Spermageddon: are humans going extinct?

A new topic a new challenge for future civilizations.

I won’t write an introduction I will ask couple of questions to make you think about it.

In the forth industrial revolution are we going to change the way we reproduce? Could be the first step for post-human era in 2040?

How can we change the way we deal with economics? Because economy depends on population grow. In a way or another world population will stop at 11 billion so it is necessary to change the economy.

How can we colonize and expand while fertility rate is going down could another creatures like machines and biological engineered animals help us to expand and the human specie will limit its population?

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AI Helps Explain How Single-Celled Organisms Move in the Desired Direction Without a Brain

How do simple creatures manage to move to a specific place? Artificial intelligence and a physical model from TU Wien can now explain this.

How is it possible to move in the desired direction without a brain or nervous system? Single-celled organisms apparently manage this feat without any problems: for example, they can swim towards food with the help of small flagellar tails.

How these extremely simply built creatures manage to do this was not entirely clear until now. However, a research team at TU Wien (Vienna) has now been able to simulate this process on the computer: They calculated the physical interaction between a very simple model organism and its environment. This environment is a liquid with a non-uniform chemical composition, it contains food sources that are unevenly distributed.

Could blocking the sun save the planet?

As the need for urgent climate solutions grows, scientists want to put more research into a technology known as solar geoengineering — the idea of chemically altering the atmosphere to reflect sunlight away from Earth.

It is seen as a potential method of cooling the planet and offsetting climate change. But could such a technology curtail a climate catastrophe — or become the cause of it?

Those against solar geoengineering fear unintended consequences, including irreversible changes to weather patterns, and many climate activists are wary of using the Earth’s atmosphere as a testing ground. Last month in Sweden, an experiment led by Harvard University researchers was cancelled following opposition by environmental and indigenous groups. Researchers had planned on testing a high-altitude balloon that could be used to disperse reflective aerosol particles into the atmosphere.

In this episode of The Stream, we’ll learn more about solar geoengineering and the debate surrounding it.

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