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Category: chemistry – Page 323

The process of combining maternal and paternal genetic information is surprisingly error-prone

Only one in three fertilizations leads to a successful pregnancy. Many embryos fail to progress beyond early development. Cell biologists at the Max Planck Institute (MPI) for Biophysical Chemistry in Göttingen (Germany), together with researchers at the Institute of Farm Animal Genetics in Mariensee and other international colleagues, have now developed a new model system for studying early embryonic development. With the help of this system, they discovered that errors often occur when the genetic material from each parent combines immediately after fertilization. This is due to a remarkably inefficient process.

Human somatic cells typically have 46 , which together carry the genetic information. These chromosomes are first brought together at fertilization, 23 from the father’s sperm, and 23 from the mother’s egg. After fertilization, the parental chromosomes initially exist in two separate compartments, known as pronuclei. These pronuclei slowly move towards each other until they come into contact. The pronuclear envelopes then dissolve, and the parental chromosomes unite.

The majority of human embryos, however, end up with an incorrect number of chromosomes. These embryos are often not viable, making erroneous genome unification a leading cause of miscarriage and infertility.

My Theory & The Future Of Aging | Prof George Church Interview Series Episode 1

7:01 they talk about Church’s comments of ending aging by 2030. Also this appears to be a part one.

In this video Professor Church talks about his theory of aging and touches on his ideas on the future of aging.

George Church is the Robert Winthrop Professor of Genetics at Harvard Medical School, a Professor of Health Sciences and Technology at Harvard and MIT. Professor Church helped initiate the Human Genome Project in 1984 and the Personal Genome Project in 2005. He is widely recognized for his innovative contributions to genomic science and his many pioneering contributions to chemistry and biomedicine. He has co-authored 580 paper, 143 patent publications & the book “Regenesis”.

George Church Links.
Professor Church’s Lab at Harvard.
https://arep.med.harvard.edu/

Professor Church’s Book on Amazon.

Continue reading “My Theory & The Future Of Aging | Prof George Church Interview Series Episode 1” | >

Perseverance Mars rover captures video, audio of fourth Ingenuity flight

For the first time, a spacecraft on another planet has recorded the sounds of a separate spacecraft. NASA’s Perseverance Mars rover used one of its two microphones to listen as the Ingenuity helicopter flew for the fourth time on April 30, 2021. A new video combines footage of the solar-powered helicopter taken by Perseverance’s Mastcam-Z imager with audio from a microphone belonging to the rover’s SuperCam laser instrument.

The laser zaps rocks from a distance, studying their vapor with a spectrometer to reveal their chemical composition. The instrument’s records the sounds of those laser strikes, which provide information on the physical properties of the targets, such as their relative hardness. The microphone can also record , like the Martian wind.

With Perseverance parked 262 feet (80 meters) from the helicopter’s takeoff and landing spot, the rover mission wasn’t sure if the microphone would pick up any sound of the flight. Even during flight, when the helicopter’s blades spin at 2537 rpm, the sound is greatly muffled by the thin Martian atmosphere. It is further obscured by Martian wind gusts during the initial moments of the flight. Listen closely, though, and the helicopter’s hum can be heard faintly above the sound of those winds.

New device can measure glucose in sweat with the touch of a fingertip

Many people with diabetes endure multiple, painful finger pricks each day to measure their blood glucose. Now, researchers reporting in ACS Sensors have developed a device that can measure glucose in sweat with the touch of a fingertip, and then a personalized algorithm provides an accurate estimate of blood glucose levels.

According to the American Diabetes Association, more than 34 million children and adults in the U.S. have diabetes. Although self-monitoring of blood glucose is a critical part of diabetes management, the pain and inconvenience caused by finger-stick blood sampling can keep people from testing as often as they should.

The researchers made a touch-based sweat glucose sensor with a polyvinyl alcohol hydrogel on top of an electrochemical sensor, which was screen-printed onto a flexible plastic strip. When a volunteer placed their fingertip on the sensor surface for 1 minute, the hydrogel absorbed tiny amounts of sweat. Inside the sensor, glucose in the sweat underwent an enzymatic reaction that resulted in a small electrical current that was detected by a hand-held device.

Dr. Anil Achyuta — TDK Ventures — Founding Member — Deep-Tech Healthcare And Energy Investments

Deep-tech healthcare & energy investments for a sustainable future — dr. anil achyuta, investment director / founding member, TDK ventures.

Dr. Anil Achyuta is an Investment Director and a Founding Member at TDK Ventures, which is a deep-tech corporate venture fund of TDK Corporation, the Japanese multinational electronics company that manufactures electronic materials, electronic components, and recording and data-storage media.

Anil is passionate about energy and healthcare sectors as he believes these are the most impactful areas to building a sustainable future – a mission directly in line with TDK Ventures’ goal.

At TDK Ventures, Anil has reviewed over 1050 start-ups and invested in: 1) Autoflight — an electric vertical take-off and landing company, 2) Genetesis — a magnetic imaging-based cardiac diagnostics company, 3) Origin — 3D printing mass manufacturing company, 4) Exo — hand-held 3D ultrasound imaging company, 5) GenCell — ammonia-to-energy hydrogen fuel cell company, 6) Mojo Vision – augmented reality contact lens company, and 7) Battery Resourcers – a direct to cathode lithium ion battery recycling company.

From his seven investments, Anil has secured two exits. GenCell IPO’d on Tel Aviv’s Stock Exchange, and Origin was acquired by the #1 3D Printing company in the world, Stratasys, for $100M.

Continue reading “Dr. Anil Achyuta — TDK Ventures — Founding Member — Deep-Tech Healthcare And Energy Investments” | >

Self-organization of nanoparticles and molecules in periodic Liesegang-type structures

Chemical organization in reaction-diffusion systems offer a strategy to generate materials with ordered morphologies and architecture. Periodic structures can be formed using molecules or nanoparticles. An emerging frontier in materials science aims to combine nanoparticles and molecules. In a new report on Science Advances, Amanda J. Ackroyd and a team of scientists in chemistry, physics and nanomaterials in Canada, Hungary and the U.S. noted how solvent evaporation from a suspension of cellulose nanocrystals (CNCs) and L-(+)-tartaric acid [abbreviated L-(+)-TA] caused the phase separation of precipitation to result in the rhythmic alteration of CNC-rich, L-(+)-TA rings. The CNC-rich regions maintained a cholesteric structure, while the L-(+)-TA-rich bands formed via radially elongated bundles to expand the knowledge of self-organizing reaction-diffusion systems and offer a strategy to design self-organizing materials.

Chemical organization

The process of self-organization and self-assembly occurs universally in non-equilibrium systems of living matter, geochemical environments, materials science and in industry. Existing experiments that lead to can be divided into two groups including the classical Liesegang-type experiments and chemical organization via periodic precipitation to generate materials with ordered morphologies and structural hierarchy. In this work, Ackroyd et al. developed a strategy for solvent evaporation to phase separate an aqueous solution of tartaric acid/cellulose nanocrystals [L-(+)-TA/CNC or TA/CNC] for its subsequent precipitation to result in a rhythmic alternation of CNC-rich or CNC-depleted ring-type regions. The team developed a kinetic model which agreed with the quantitatively. The work expands the range of self-organizing reaction-diffusion systems to pave the way for periodically structured functional materials.

Watch the self healing fabric that could save your favourite clothes

Circa 2016

Clothing of the future could have the ability to repair itself after a tear – all you need to do is add water.

Researchers have developed a coating for textiles that can heal itself, and neutralize harmful chemicals.

They say this could one day be used to make chemically protective suits, helping to keep everyone from soldiers to farmers safe from toxic materials.

Molecules brought in a single quantum state

Breakthrough in quantum chemistry has implications for quantum technology.

Quantum technology has a lot of promise, but several research barriers need to be overcome before it can be widely used. A team of US researchers has advanced the field another step, by bringing multiple molecules into a single quantum state at the same time.

A Bose-Einstein condensate is a state of matter that only occurs at very low temperatures – close to absolute zero. At this temperature, multiple particles can clump together and behave as though they were a single atom – something that could be useful in quantum technology. But while scientists have been able to get single atoms into this state for decades, they hadn’t yet achieved it with molecules.

“Atoms are simple spherical objects, whereas molecules can vibrate, rotate, carry small magnets,” says Cheng Chin, a professor of physics at the University of Chicago, US. “Because molecules can do so many different things, it makes them more useful, and at the same time much harder to control.”