Lifeboat Foundation

More information on the search for natural senolytics (that clear the senescent cells and potentially make us younger)- on ficetin, found in abundance for example in strawberries, a newly published study and discussion in the blog of Josh Mitteldorf. But we still would have to consume around 20 kg strawberries for two consecutive days to reach the dose used in the happy longer living mice!

Senolytic drugs have been the most promising near-term anti-aging therapy since the ground-breaking paper by van Deursen of Mayo Clinic published in 2011 . The body accumulates senescent cells as we age, damaged cells that send out signal molecules that in turn modify our biochemistry in a toxic, pro-inflammatory direction. Though the number of such cells is small, the damage they do is great. Van Deursen showed that just getting rid of these cells could increase lifespan of mice by ~25%. But he did it with a trick, using genetically engineered mice in which the senescent cells had a built-in self-destruct switch.

After that, the race was on to find chemical agents that would do the same thing without the genetically engineered self-destruct. They must selectively kill senescent cells, while leaving all other cells unharmed. It’s a tall order, because even a little residual toxicity to normal cells can be quite damaging. Before last week, the two best candidates were FOXO4-DRI and a combination of quercetin with dasatinib .

Continue reading “Fisetin—a new senolytic” »

Thoughts on the Eurosymposium on Healthy Ageing held by Heales in Brussels.

When I first learned about the possibility of achieving human rejuvenation through biotechnological means, little did I know that this would lead me to meet many of the central figures in the field during a conference some seven years later—let alone that I would be speaking at the very same event. Yet, I’ve had the privilege to attend the Fourth Eurosymposium on Healthy Ageing (EHA) held in Brussels on November 8–10, an experience that gave me a feel of just how real the prospect of human rejuvenation is.

A friendly, welcoming environment

Continue reading “Thoughts on the 2018 Eurosymposium on Healthy Ageing” »

Jump to media player The surprisingly simple science behind the clever chemistry that helps your night go off with a bang.

Eat This, Not That! –Bioquark Inc.

https://www.eatthis.com/tips-to-live-longer/

Wonderful to see the continuing progress of Mr. Omar Flores, with the support of his lovely wife, actress Mayra Sierra, today on the Venga la Alegria (VLA) show on TV Azteca (http://www.aztecauno.com/vengalaalegria) — The importance of an integrated approach to curing spinal cord injury including family, physical therapists, and the medical team at Regenerage (https://regenerage.clinic/)

https://www.youtube.com/watch?v=RRLo45i8q_A&t=4s

MIT has launched the Stephen A. Schwarzman College of Computing, a $1 billion center dedicated to “reshaping its academic program” around AI. The idea, said MIT president L. Rafael Reif, is to use AI, machine learning and data science with other academic disciplines to “educate the bilinguals of the future,” defining bilingual as those working in biology, chemistry, politics, history and linguistics with computing skills that can be used in their field.

By using the power of evolution to solve practical problems, three researchers opened new avenues to chemical discovery.

Optical frequency combs can enable ultrafast processes in physics, biology, and chemistry, as well as improve communication and navigation, medical testing, and security. The Nobel Prize in Physics 2005 was awarded to the developers of laser-based precision spectroscopy, including the optical frequency comb technique, and microresonator combs have become an intense focus of research over the past decade.

A major challenge has been how to make such comb sources smaller and more robust and portable. In the past 10 years, major advances have been made in the use of monolithic, chip-based microresonators to produce such combs. While the microresonators generating the frequency combs are tiny—smaller than a human hair—they have always relied on external lasers that are often much larger, expensive, and power-hungry.

Researchers at Columbia Engineering announced today in Nature that they have built a Kerr frequency comb generator that, for the first time, integrates the laser together with the microresonator, significantly shrinking the system’s size and power requirements. They designed the laser so that half of the laser cavity is based on a semiconductor waveguide section with high optical gain, while the other half is based on waveguides, made of silicon nitride, a very low-loss material. Their results showed that they no longer need to connect separate devices in the lab using fiber—they can now integrate it all on photonic chips that are compact and energy efficient.

In a new scientific article, researchers at Uppsala University describe how, using a completely new method, they have synthesised an artificial enzyme that functions in the metabolism of living cells. These enzymes can utilize the cell’s own energy, and thereby enable hydrogen gas to be produced from solar energy.

Hydrogen gas has long been noted as a promising energy carrier, but its production is still dependent on fossil raw materials. Renewable hydrogen gas can be extracted from water, but as yet the systems for doing so have limitations.

In the new article, published in the journal Energy and Environmental Science, an interdisciplinary European research group led by Uppsala University scientists describe how artificial enzymes convert solar energy into hydrogen gas. This entirely new method has been developed at the University in the past few years. The technique is based on photosynthetic microorganisms with genetically inserted enzymes that are combined with synthetic compounds produced in the laboratory. Synthetic biology has been combined with synthetic chemistry to design and create custom artificial enzymes inside living organisms.

Continue reading “Artificial enzymes convert solar energy into hydrogen gas” »