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Category: chemistry – Page 294

Scientists from UNSW Sydney have developed a ceramic-based ink that may allow surgeons in the future to 3D-print bone parts complete with living cells that could be used to repair damaged bone tissue.

Using a 3D-printer that deploys a special ink made up of calcium phosphate, the scientists developed a new technique, known as ceramic omnidirectional bioprinting in cell-suspensions (COBICS), enabling them to print -like structures that harden in a matter of minutes when placed in water.

While the idea of 3D-printing bone-mimicking structures is not new, this is the first time such material can be created at room temperature—complete with living cells—and without harsh chemicals or radiation, says Dr. Iman Roohani from UNSW’s School of Chemistry.

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Fair to say that we all assume that aging is inevitable. In reality however, there is no biological law that says we must age. Over the years we’ve seen a variety of theories proposed to explain why we age including the accumulation of damage to our DNA, the damaging effects of chemicals called “free radicals, changes in the function of our mitochondria, and so many others.

Our guest today, Dr. David Sinclair, believes that aging is related to a breakdown of information. Specifically, he describes how, with time, our epigenome accumulates changes that have powerful downstream effects on the way our DNA functions. Reducing these changes to the epigenome is achievable and in fact, even taking it further, his research now reveals that the epigenome can be reprogrammed back to a youthful state.

David A. Sinclair, PhD, AO is Professor of Genetics at Harvard Medical School, and is the author of Lifespan — Why We Age and Why We Don’t Have To. He is the Founding Director of the Paul F. Glenn Center for the Biological Mechanisms of Aging at Harvard. One of the leading innovators of his generation, he is listed by TIME magazine as one of the “100 most influential people in the world” (2014) and top 50 most important people in healthcare (2018). He is a board member of the American Federation for Aging Research, a Founding Editor of the journal Aging, and has received more than 35 awards for his research on resveratrol, NAD, and reprogramming to reverse aging, which have been widely hailed as major scientific breakthroughs and are topics we discuss in our time together.

In 2018, Dr. Sinclair became an Officer of the Order of Australia, the equivalent of a knighthood, for his work on national security matters and human longevity. Dr. Sinclair and his work have been featured on 60 Minutes, Today, The Wall Street Journal, The New York Times, Fortune, and Newsweek, among others.

Continue reading “The Empowering Neurologist — David Perlmutter M.D., and Dr. David Sinclair” | >

Spiral galaxies are one of the most commonly known types of galaxy. Most people think of them as large round disks, and know that our Milky Way is counted among their number. What most people don’t realize is that many spiral galaxies have a type of warping effect that, when you look at them edge on, can make it seem like they are forming a wave. Now scientists, led by Xinlun Chen at the University of Virginia, have studied millions of stars in the Milky Way and begun to develop a picture of a “wave” passing through our own galaxy.

Since humans are not currently able to view the Milky Way in an edge-on orientation, they must resort to more brute force methods to develop models about the what, if any, wave our galaxy has. Luckily, scientists now have the tools to do so, in the form of the Sloan Digital Sky Survey and ESA’s Gaia satellite.

The method the team used was to try to identify and track the motions of as many stars as possible. To do this, they used the Apache Point Observatory Galactic Evolution Experiment (APOGEE) spectrograph, which is part of the SDSS. This preliminary data allowed them to look at both the chemical compositions as well as the motions of hundreds of thousands of stars. While this motion data was helpful in starting to form the picture of the Milky Way’s wave, it was not sufficient to complete it.

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I like this idea. I don’t want AI to be a black box, I want to know what’s happening and how its doing it.

The field of artificial intelligence has created computers that can drive cars, synthesize chemical compounds, fold proteins, and detect high-energy particles at a superhuman level.

However, these AI algorithms cannot explain the thought processes behind their decisions. A computer that masters protein folding and also tells researchers more about the rules of biology is much more useful than a computer that folds proteins without explanation.

Therefore, AI researchers like me are now turning our efforts toward developing AI algorithms that can explain themselves in a manner that humans can understand. If we can do this, I believe that AI will be able to uncover and teach people new facts about the world that have not yet been discovered, leading to new innovations.

Continue reading “How Explainable Artificial Intelligence Can Help Humans Innovate” | >

The ultimate goal of the Old World alchemist was to turn inexpensive metals into gold. Modern-day physicists at the University of Rochester’s Institute of Optics (Rochester, NY), have turned aluminum and other metals gold—in color if not chemistry. A femtosecond laser processing technique created by professor Chunlei Guo and his assistant Anatoliy Vorobeyv alters the surface properties of aluminum, platinum, titanium, tungsten, silver, and gold to create tints of gold, blue, gray, black, and even multicolored irridescence.

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The SonoMask displayed an ability to neutralize the novel coronavirus at an effectiveness of 99.34% within trials performed by the ATCCR Testing laboratory in China, Ramat Gan-based Israeli fabric maker and developer Sonovia announced on Saturday. Sonovia’s reusable anti-viral masks are coated in zinc oxide nanoparticles that destroy bacteria, fungi and viruses, which it says can help stop the spread of the coronavirus. Results from the most recent round of testing showed that the mask has the ability to neutralize fallen traces of SARS-COV-2 within 30 minutes after making contact with the fabric. The SonoMask was also proven to maintain its protective properties throughout 55 wash cycles.” Following this outstanding result – the product of several months of dedicated anti-viral sonochemistry formulation – we can now assure the public that our SonoMask is working continuously, permanently and rapidly to neutralize the spread of COVID-19,” said Sonovia CEO Joshua Hershcovici. “We are proud of our latest accomplishment that will help people feel safe and protect their loved ones, all the while remaining the most ecologically sound option upon the PPE market.” Sonovia also participated in trials with Adler Plastic in Italy earlier this year, working toward creating a solution for carpets and other types of fabrics. The company boasted a 99.999% efficiency rate against bacteria during the pilot testing round. Furthermore, the Israeli fabric maker has attracted the cooperation of top brands such as Gucci, Chanel and Adidas, working on the Fashion for Good Plug and Play accelerator project – and earning a $250000 investment for their innovation.” We see our breakthrough technology transforming our everyday life, implemented in all textiles surrounding us: from the clothes we wear, to the textiles in our home, the textiles in our public spaces, in public transportation and of course as a protective measure in the workplaces & medical institutes – in a manner that ensures safer surroundings during these unusual times,” said Sonovia’s Chief Technology Officer Liat Goldhammer.

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Advanced optoelectronics require materials with newly engineered characteristics. Examples include a class of materials named metal-halide perovskites that have tremendous significance to form perovskite solar cells with photovoltaic efficiencies. Recent advances have also applied perovskite nanocrystals in light-emitting devices. The unusually efficient light emission of cesium lead-halide perovskite may be due to a unique excitonic fine structure made of three bright triplet states that minimally interact with a proximal dark singlet state. Excitons are electronic excitations responsible for the emissive properties of nanostructured semiconductors, where the lowest-energy excitonic state is expected to be long lived and hence poorly emitting (or ‘dark’).

In a new report now published in Science Advances, Albert Liu and a team of scientists in physics and chemistry at the University of Michigan, U.S., and Campinas State University, Brazil, used multidimensional coherent spectroscopy at cryogenic (ultra-cold) temperatures to study the fine structure without isolating the cube-shaped single . The work revealed coherences (wave properties relative to space and time) involving the triplet states of a cesium lead-iodide (CsPbI3) nanocrystal ensemble. Based on the measurements of triplet and inter-triplet coherences, the team obtained a unique exciton fine structure level ordering composed of a dark state, energetically positioned within the bright triplet manifold.

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Numerous natural products are awaiting discovery in all kinds of natural habitats. Especially microorganisms such as bacteria or fungi are able to produce diverse natural products with high biomedical application potential in particular as antibiotics and anticancer agents. This includes the so-called red yeast of the species Rhodotorula mucilaginosa, isolated from a deep-sea sediment sample from the Mid-Atlantic Ridge and analyzed for its genome and chemical constituents by researchers from GEOMAR Centre for Marine Biotechnology (GEOMAR-Biotech) of GEOMAR Helmholtz Centre for Ocean Research Kiel and Kiel University (CAU). In a joint effort, the scientists succeeded in demonstrating its anticancer and antibacterial effects. This study, partly-funded by Kiel Marine Science (KMS) of Kiel University, was recently published in the renowned scientific journal Marine Drugs.

A unique opportunity arose for researchers in the Department of Botanical Genetics and Molecular Biology at Kiel University, headed by Professor Frank Kempken. Via the Institute of Geosciences at Kiel University, his group had access to sediment samples from the Mid-Atlantic Ridge in 1600—4000 m depth collected during a research cruise with the German research vessel MARIA S. MERIAN. From one of these sediment cores taken at a depth of 3600 m, Prof. Kempken´s group succeeded in isolating and cultivating living fungi of the species Rhodotorula mucilaginosa. This slowly growing type of yeast, which belongs to the so-called Basidiomycete yeasts should not be confused with the well-known baker’s yeast. The species originally grows at great depth tolerating high hydrostatic pressure and rather cold temperatures.

“With the applied methodology we have succeeded in cultivating yeast colonies that can withstand and grow at room temperatures and under atmospheric pressure. These experiments have shown once more that microorganisms with specific physiological properties thrive in distinct ecological niches. The experiments have shown us further that special ecological niches can produce microorganisms with special characteristics. The assumption about the adaptability of this special genus has therefore encouraged us to further analyze this species,” says Kempken, whose research group has been analyzing genomes of marine fungi for more than ten years.

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Researchers at Osaka City University use quantum superposition states and Bayesian inference to create a quantum algorithm, easily executable on quantum computers, that accurately and directly calculates energy differences between the electronic ground and excited spin states of molecular systems in polynomial time.

Understanding how the natural world works enables us to mimic it for the benefit of humankind. Think of how much we rely on batteries. At the core is understanding molecular structures and the behavior of electrons within them. Calculating the energy differences between a molecule’s electronic ground and excited spin states helps us understand how to better use that molecule in a variety of chemical, biomedical and industrial applications. We have made much progress in molecules with closed-shell systems, in which electrons are paired up and stable. Open-shell systems, on the other hand, are less stable and their underlying electronic behavior is complex, and thus more difficult to understand. They have unpaired electrons in their ground state, which cause their energy to vary due to the intrinsic nature of electron spins, and makes measurements difficult, especially as the molecules increase in size and complexity.

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Imagine going to a surgeon to have a diseased or injured organ switched out for a fully functional, laboratory-grown replacement. This remains science fiction and not reality because researchers today struggle to organize cells into the complex 3D arrangements that our bodies can master on their own.

There are two major hurdles to overcome on the road to laboratory-grown organs and tissues. The first is to use a biologically compatible 3D in which cells can grow. The second is to decorate that scaffold with biochemical messages in the correct configuration to trigger the formation of the desired organ or tissue.

In a major step toward transforming this hope into reality, researchers at the University of Washington have developed a technique to modify naturally occurring biological polymers with protein-based biochemical messages that affect cell behavior. Their approach, published the week of Jan. 18 in the Proceedings of the National Academy of Sciences, uses a near-infrared laser to trigger chemical adhesion of protein messages to a scaffold made from biological polymers such as collagen, a connective tissue found throughout our bodies.

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