Lifeboat Foundation

When Dr. Robert Murphy first started researching biochemistry and drug development in the late 1970s, creating a pharmaceutical compound that was effective and safe to market followed a strict experimental pipeline that was beginning to be enhanced by large-scale data collection and analysis on a computer.

Now head of the Murphy Lab for computational biology at Carnegie Mellon University (CMU), Murphy has watched over the years as data collection and artificial intelligence have revolutionized this process, making the drug creation pipeline faster, more efficient, and more effective.

Recently, that’s been thanks to the application of machine learning—computer systems that learn and adapt by using algorithms and statistical models to analyze patterns in datasets—to the drug development process. This has been notably key to reducing the presence of side effects, Murphy says.

Brains aren’t the easiest of organs to study, what with their delicate wiring and subtle whispering of neurotransmitter messages. Now, this research could be made a little easier, as we’ve learned we can swap some critical chemical systems with the host animal being none the wiser.

In a proof-of-concept study run by a team of US researchers, the microscopic worm Caenorhabditis elegans was genetically gifted pieces of a nervous system taken from a radically different creature – a curious freshwater organism known as Hydra.

The swap wasn’t unlike teaching a specific brain circuit a foreign language, and finding it performs its job just as well as before.

Developing drugs for a range of tauopathies — dr leticia toledo-sherman, senior director, drug discovery, tau consortium, rainwater charitable foundation.

Dr. Leticia Toledo-Sherman is Senior Director of Drug Discovery of the Tau Consortium (https://tauconsortium.org/) for The Rainwater Charitable Foundation (https://rainwatercharitablefoundation.org/medical-research) and also holds an appointment as Adjunct Assistant Professor of Neurology at UCLA.

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Autonomous weapon systems – commonly known as killer robots – may have killed human beings for the first time ever last year, according to a recent United Nations Security Council report on the Libyan civil war. History could well identify this as the starting point of the next major arms race, one that has the potential to be humanity’s final one.

Autonomous weapon systems are robots with lethal weapons that can operate independently, selecting and attacking targets without a human weighing in on those decisions. Militaries around the world are investing heavily in autonomous weapons research and development. The U.S. alone budgeted US$18 billion for autonomous weapons between 2016 and 2020.

Meanwhile, human rights and humanitarian organizations are racing to establish regulations and prohibitions on such weapons development. Without such checks, foreign policy experts warn that disruptive autonomous weapons technologies will dangerously destabilize current nuclear strategies, both because they could radically change perceptions of strategic dominance, increasing the risk of preemptive attacks, and because they could become combined with chemical, biological, radiological and nuclear weapons themselves.

A possible explanation for life from nonliving material.

Exactly how life first emerged from non-living matter is one of the most enduring mysteries of science. In a new study, Japanese scientists have created self-replicating protocells in the lab, which they say could represent the “missing link” between chemistry and biology.

Primitive Earth was covered with a sludgy mix of chemicals, containing organic molecules that formed the precursors for vital biological components like proteins and amino acids. There are several different hypotheses for how and where life sprang out of this soup, but one of the first ideas was known as chemical evolution, which is what the new study investigated.

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When people think about the search for life beyond Earth they often think about looking beyond our solar system and even beyond our galaxy. But what about looking closer to home? Titan, Saturn’s largest moon has a dense atmosphere, an internal liquid water ocean, and stable bodies of liquid methane on its surface. While we have not found any evidence of life on Titan, its chemistry and environment make it an interesting place to explore. Europa is a moon of Jupiter with a water-ice crust and liquid ocean underneath. Its atmosphere is very thin, but it’s composed mostly of oxygen.

Zibi (Elizabeth) Turtle is the principal investigator of the Dragonfly mission which will land a drone-like vehicle on Titan to conduct sorties to sample and examine sites around Titan. Morgan Cable is also on the Dragonfly Team, and both Zibi and Morgan are working on the Europa Clipper mission which will perform reconnaissance of Europa to investigate whether it could have conditions suitable for life. Join Zibi and Morgan, along with SETI Institute planetary astronomer Franck Marchis for their discussion about what makes Titan and Europa such intriguing places to search for clues about the origins of life in our solar system.

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An international team of researchers has used liquid gallium to create an antiviral and antimicrobial coating and tested it on a range of fabrics, including facemasks. The coating adhered more strongly to fabric than some conventional metal coatings, and eradicated 99% of several common pathogens within five minutes.

“Microbes can survive on the fabrics hospitals use for bedding, clothing and face masks for a long time,” says Michael Dickey, co-corresponding author of a paper on the work and Camille & Henry Dreyfus Professor of Chemical and Biomolecular Engineering at North Carolina State University. “Metallic surface coatings such as copper or silver are an effective way to eradicate these pathogens, but many metal particle coating technologies have issues such as non-uniformity, processing complexity, or poor adhesion.”

Dickey and colleagues from NC State, Sungkyunkwan University (SKKU) in Korea and RMIT University in Australia set out to develop a simple, cost-effective way to deposit metal coatings on fabric.

Feeding the world uses enormous amounts of land, water, fertilizer, pesticide, and fuel. In a step towards a more sustainable solution, researchers have designed a method to make starches from carbon dioxide more efficiently than plants do (Science 2,021 DOI: 10.1126/science.abh4049).

The new technique, which relies on chemical catalysts and a curated combination of natural and engineered enzymes, converts CO₂ to starch 8.5 times as efficiently as corn plants can.

The advance hints at sustainable, efficient factory production of food and industrial chemicals by.

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Quantum physics is directly linked to consciousness: Observations not just change what is measured, they create it… Here’s the next episode of my new documentary Consciousness: Evolution of the Mind (2021), Part II: CONSCIOUSNESS & INFORMATION

*Subscribe to our YT channel to watch the rest of documentary (to be released in parts): https://youtube.com/c/EcstadelicMedia.

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