Of course, this study was performed on a relatively small group of individuals in an agricultural community, which is not the environment that most American teenagers grow up in. These links may also be due to some other confounding factors, like spending more time on the farm than in formal education. However, these results are still striking and important to consider for young people in farming communities (and non-farming communities) around the world.
“Many chronic diseases and mental-health disorders in adolescents and young adults have increased over the last two decades worldwide, and exposure to neurotoxic contaminants in the environment could explain a part of this increase,” senior author Jose Ricardo Suarez, an associate professor in the Herbert Wertheim School of Public Health, said in a statement.
“Hundreds of new chemicals are released into the market each year, and more than 80,000 chemicals are registered for use today,” Suarez added. “Sadly, very little is known about the safety and long-term effects on humans for most of these chemicals. Additional research is needed to truly understand the impact.”
Some asteroids have measured densities higher than those of any elements known to exist on Earth. This suggests that they are at least partly composed of unknown types of “ultradense” matter that cannot be studied by conventional physics.
Jan Rafelski and his team at the Department of Physics, The University of Arizona, Tucson, U.S., suggest that this could consist of superheavy elements with atomic number (Z) higher than the limit of the current periodic table.
They modeled the properties of such elements using the Thomas-Fermi model of atomic structure, concentrating particularly on a proposed “island of nuclear stability” at and around Z=164 and extending their method further to include more exotic types of ultra-dense material. This work has now been published in The European Physical Journal Plus.
This is a bit technical. “nucleocytoplasmic compartmentalization assay”, Yeah buddy.
Life is dependent on the preservation and storage of information. The genome and epigenome are the two central storehouses of information in eukaryotes, and although they work interdependently, they are fundamentally quite different. Genetic information is consistent across all body cells throughout the life of an individual while epigenetic information varies between cells as well as changes over time and as per environment.
Researchers have identified several hallmarks of aging such as epigenetic alterations, genomic instability, cellular senescence, telomere attrition, mitochondrial dysfunction, and others [1]. These are known to play a role in the dysfunction and deterioration of cells with age. David Sinclair and other researchers have previously indicated that loss of epigenetic information can cause changes in gene expression, leading to cellular identity loss. Previous studies in mice have also shown that cell injuries such as cell crushing and DNA double-strand breaks can promote loss of epigenetic information which can accelerate aging along with age-related diseases [2].
Cellular senescence is a state of stable cell cycle arrest that can be triggered due to a wide range of extrinsic as well as intrinsic factors. It promotes tissue remodeling, wound repair, and cancer prevention by stopping the proliferation of damaged and aged cells. Senescent cells are characterized by metabolic and morphological alterations, reorganization of the chromatin, and release of pro-inflammatory substances known as the senescence-associated secretory phenotype (SASP) [3]. Irreparable DNA damage, loss of epigenetic information, and telomere shortening are a few factors that can initiate cellular senescence. Accumulation of senescent cells with age results in inflammation as well as the generation of reactive oxygen species (ROS).
A new model demonstrates that chasing interactions can induce dynamical patterns in the organization of bacterial species. Structural patterns can be created due to the chasing interactions between two bacterial species.
In the new model, scientists from the Max Planck Institute for Dynamics and Self-Organization (MPI-DS) describe how interactions on the individual level can result in a global self-organization of species. Their findings provide insights into general mechanisms of collective behavior. The findings are published in the journal Physical Review Letters.
In a recent study, scientists from the department Living Matter Physics at MPI-DS developed a model describing communication pathways in bacterial populations. Bacteria show an overall organizational pattern by sensing the concentration of chemicals in their environment and adapting their motion.
BPA is used in a lot of plastics and plastic production processes, and can also be found inside food and drink cans. However, previous research has also linked it to health issues involving hormone disruption, including breast cancer and infertility.
In this new study, researchers from Rowan University and Rutgers University in the US looked at three groups of children: 66 with autism, 46 with ADHD, and 37 neurotypical kids. In particular, they analyzed the process of glucuronidation, a chemical process the body uses to clear out toxins within the blood through urine.
This year’s Nobel Prize in Chemistry recognizes the development of quantum dots, particles whose size controls their color, making them useful for technologies such as displays.
Scientists have caught fast-moving hydrogen atoms—the keys to countless biological and chemical reactions—in action.
A team led by researchers at the Department of Energy’s SLAC National Accelerator Laboratory and Stanford University used ultrafast electron diffraction (UED) to record the motion of hydrogen atoms within ammonia molecules. Others had theorized they could track hydrogen atoms with electron diffraction, but until now nobody had done the experiment successfully.
The results, published in Physical Review Letters, leverage the strengths of high-energy Megaelectronvolt (MeV) electrons for studying hydrogen atoms and proton transfers, in which the singular proton that makes up the nucleus of a hydrogen atom moves from one molecule to another.
Written and produced by Yale Neuroscience PhD student Clara Liao.
Addiction is now understood to be a brain disease. Whether it’s alcohol, prescription pain pills, nicotine, gambling, or something else, overcoming an addiction isn’t as simple as just stopping or exercising greater control over impulses. That’s because addiction develops when the pleasure circuits in the brain get overwhelmed, in a way that can become chronic and sometimes even permanent. This is what’s at play when you hear about reward “systems” or “pathways” and the role of dopamine when it comes to addiction. But what does any of that really mean? One of the most primitive parts of the brain, the reward system, developed as a way to reinforce behaviors we need to survive—such as eating. When we eat foods, the reward pathways activate a chemical called dopamine, which, in turn, releases a jolt of satisfaction. This encourages you to eat again in the future. When a person develops an addiction to a substance, it’s because the brain has started to change. This happens because addictive substances trigger an outsized response when they reach the brain. Instead of a simple, pleasurable surge of dopamine, many drugs of abuse—such as opioids, cocaine, or nicotine—cause dopamine to flood the reward pathway, 10 times more than a natural reward. The brain remembers this surge and associates it with the addictive substance. However, with chronic use of the substance, over time the brain’s circuits adapt and become less sensitive to dopamine. Achieving that pleasurable sensation becomes increasingly important, but at the same time, you build tolerance and need more and more of that substance to generate the level of high you crave. Addiction can also cause problems with focus, memory, and learning, not to mention decision-making and judgement. Seeking drugs, therefore, is driven by habit—and not conscious, rational decisions. Unfortunately, the belief that people with addictions are simply making bad choices pervades. Furthermore, the use of stigmatizing language, such as “junkie” and “addict” and getting “clean,” often creates barriers when it comes to accessing treatment. There’s also stigma that surrounds treatment methods, creating additional challenges. Though treatment modalities differ based on an individual’s history and the particular addiction he or she has developed, medications can make all the difference. “A lot of people think that the goal of treatment for opioid use disorder, for example, is not taking any medication at all,” says David A. Fiellin, MD, a Yale Medicine primary care and addiction medicine specialist. “Research shows that medication-based treatments are the most effective treatment. Opioid use disorder is a medical condition just like depression, diabetes or hypertension, and as with those conditions, it is most effectively treated with a combination of medication and counseling.”
Missions to the Moon, missions to Mars, robotic explorers to the outer Solar System, a mission to the nearest star, and maybe even a spacecraft to catch up to interstellar objects passing through our system. If you think this sounds like a description of the coming age of space exploration, then you’d be correct! At this moment, there are multiple plans and proposals for missions that will send astronauts and/or probes to all of these destinations to conduct some of the most lucrative scientific research ever performed. Naturally, these mission profiles raise all kinds of challenges, not the least of which is propulsion.
Simply put, humanity is reaching the limits of what conventional (chemical) propulsion can do. To send missions to Mars and other deep space destinations, advanced propulsion technologies are required that offer high acceleration (delta-v), specific impulse (Isp), and fuel efficiency. In a recent paper, Leiden Professor Florian Neukart proposes how future missions could rely on a novel propulsion concept known as the Magnetic Fusion Plasma Drive (MFPD). This device combines aspects of different propulsion methods to create a system that offers high energy density and fuel efficiency significantly greater than conventional methods.
Florian Neukart is an Assistant Professor with the Leiden Institute of Advanced Computer Science (LIACS) at Leiden University and a Board Member of the Swiss quantum technology developer Terra Quantum AG. The preprint of his paper recently appeared online and is being reviewed for publication in Elsevier. According to Neukart, technologies that can surmount conventional chemical propulsion (CCP) are paramount in the present era of space exploration. In particular, these technologies must offer greater energy efficiency, thrust, and capability for long-duration missions.
The Nobel Physics Prize was awarded on Tuesday to three scientists for their work on attoseconds, which are almost unimaginably short periods of time.
Their work using lasers gives scientists a tool to observe and possibly even manipulate electrons, which could spur breakthroughs in fields such as electronics and chemistry, experts told AFP.
Attoseconds are a billionth of a billionth of a second.
