Lifeboat Foundation

Cancer remains one of the leading causes of death in the US at over 600,000 deaths per year. Cancers that form solid tumors such as in the breast, brain, or skin are particularly hard to treat. Surgery is typically the first line of defense for patients fighting solid tumors. But surgery may not remove all cancerous cells, and leftover cells can mutate and spread throughout the body. A more targeted and wholistic treatment could replace the blunt approach of surgery with one that eliminates cancer from the inside using our own cells.

Dennis Discher, Robert D. Bent Professor of Chemical and Biomolecular Engineering, and postdoctoral fellow Larry Dooling provide a new approach in targeted therapies for solid tumor cancers in their study, published in Nature Biomedical Engineering. Their therapy not only eliminates cancerous cells, but teaches the immune system to recognize and kill them in the future.

The disposal of tires represents a significant burden on the environment, so companies like Marangoni developed methods to recycle and reuse old tires. Watch how retreading machines make old tires usable again.

Following is a transcript of the video.

Narrator: When your tire wears out, you take it to a shop where it’s tossed out for a new one. The discarded tire is typically recycled — ground up and chemically broken down to use as a building material in streets or parks. Some companies hope to recycle differently. For years, companies like Marangoni have been saving tire casings, replacing the old tread (the rubber that touches the ground) with new tread in a process called “retreading.” These tires are not only easier to make — they typically take 20% of the energy of creating a new tire — they perform well too, standing up to the same tests that one-use tires are subjected to.

Carbon nanotubes (CNTs) are considered ideal electrochemical energy storage materials due to their high electrical conductivity, large theoretical surface area, and good chemical stability.

However, CNTs tend to aggregate due to strong van der Waals forces, which reduces their electrochemically active area. This problem is even worse for single-walled carbon nanotubes (SWNTs) due to their high length-to-diameter ratio.

Recently, a joint research team led by Dr. Wang Xiao from the Shenzhen Institute of Advanced Technology (SIAT) of the Chinese Academy of Sciences, Dr. Zhu Sheng from Shanxi University, and Prof. Li Yan from Peking University has encapsulated polyoxometalate guest molecules within SWNTs (with a diameter of approximately 1.4 nm) to enhance the electrochemical energy storage of CNTs.

Chemical signals from contracting muscles can influence the growth of brain networks, according to new research published in Neuroscience. The study highlights the importance of physical activity to mental health, and the findings could also help contribute to the development of more effective treatments for cognitive disorders such as Alzheimer’s disease.

Previous studies had shown that exercise has significant benefits for cognitive health, even when initiated at late stages in life. Exercise has been associated with long-term changes in the hippocampus, a brain region crucial for learning and memory, including increased neurogenesis, synaptogenesis, and enlarged volume.

However, the specific mechanisms through which exercise produces these changes in the hippocampus were not well understood. By uncovering these mechanisms, the authors behind the new study aim to develop exercise-based treatments for cognitive pathologies that affect the hippocampus, such as Alzheimer’s disease, stress, depression, anxiety, and normal aging.

The Human Genome Project (HGP), the world’s largest collaborative biological project, was a 13-year effort led by the U.S. government with the goal of generating the first full sequence of the human genome. In 2003, HGP produced a genome sequence that accounted for more than 90% of the human genome and was considered as close to complete as was possible with the technologies of the time. HGP unlocked the door to a vast but unannotated collection of genes.

In the following decades, via experimental studies, researchers painstakingly curated reannotations in the form of biochemical reaction graphs. Though gene set enrichment analysis considers groups within these annotation graphs, it disregards group dependencies.

Researchers from the University of Hawaii at Mānoa John A. Burns School of Medicine (JABSOM) are utilizing data from HGP and making advancements in biochemical reaction network analysis. Their work, published in the May 22, 2023 issue of Patterns, demonstrates their approach and may help predict the effects of rare or indistinct genetic variations and guide precision medicine (treatment that can use a patient’s own genes to help fight disease or guide specific therapy).

Imagine the possibility of life forms on other planets that don’t resemble any on Earth. What might they look like, and why would they be so different?

Juan Pérez-Mercader says it may be possible and the answer may be that they developed from a different type of chemistry. For more than 10 years, the senior research fellow in the Department of Earth & Planetary Sciences and the Origins of Life Initiative at Harvard has studied how to produce synthetic living systems—without relying on biochemistry, or the chemistry that has enabled life on Earth.

“We have been trying to build a non-biochemical system, which unaided is capable of executing the essential properties common to all natural living systems,” Pérez-Mercader explained.

Year 2019 😗😁

Hepatology and drug development for liver diseases require in vitro liver models. Typical models include 2D planar primary hepatocytes, hepatocyte spheroids, hepatocyte organoids, and liver-on-a-chip. Liver-on-a-chip has emerged as the mainstream model for drug development because it recapitulates the liver microenvironment and has good assay robustness such as reproducibility. Liver-on-a-chip with human primary cells can potentially correlate clinical testing. Liver-on-a-chip can not only predict drug hepatotoxicity and drug metabolism, but also connect other artificial organs on the chip for a human-on-a-chip, which can reflect the overall effect of a drug. Engineering an effective liver-on-a-chip device requires knowledge of multiple disciplines including chemistry, fluidic mechanics, cell biology, electrics, and optics.

The 2020 Nobel Prize for Chemistry was awarded to Dr. Jennifer Doudna and Dr. Emmanuelle Charpentier for their work on the gene editing technique known as CRISPR-Cas9. This gives us the ability to change the DNA of any living thing, from plants and animals to humans.

The applications are enormous, from improving farming to curing diseases. A decade or so from now, CRISPR will no doubt be taught in High Schools, and be a basic building block of medicine and agriculture. It is going to change everything.

Continue reading “Throw Forward Thursday: CRISPR” »

Sucralose, a widely used artificial sweetener, produces a DNA

DNA, or deoxyribonucleic acid, is a molecule composed of two long strands of nucleotides that coil around each other to form a double helix. It is the hereditary material in humans and almost all other organisms that carries genetic instructions for development, functioning, growth, and reproduction. Nearly every cell in a person’s body has the same DNA. Most DNA is located in the cell nucleus (where it is called nuclear DNA), but a small amount of DNA can also be found in the mitochondria (where it is called mitochondrial DNA or mtDNA).