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5 SLE Patients See Disease Remission With CAR T-cell Therapy

A CAR T-cell therapy targeting disease-driving immune cells safely led to sustained disease remission for five people with systemic lupus erythematosus (SLE) who’d previously failed to respond to other treatments, a recent study reported.

Treatment was also highly specific, preventing autoimmune activity, but didn’t impair general immune system function.

“These data provide new therapeutic possibilities to control SLE disease activity,” the researchers wrote. “Longer follow-ups in larger cohorts of patients will be necessary to confirm sustained absence of autoimmunity and resolution of inflammation in patients with SLE who have received CAR T cell therapy.”

Nature Abstract.

https://www.nature.com/articles/s41591-022-02017-5

No systemic lupus erythematosus patient receiving the CAR T-cell therapy infusion relapsed, all remained in remission for up to 17 months.

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Vaccine delivers a boost to T cell therapy

Engineering T cells to destroy cancer cells has shown success in treating some types of cancer, such as leukemia and lymphoma. However, it hasn’t worked as well for solid tumors.

One reason for this lack of success is that the T cells target only one antigen (a target protein found on the tumors); if some of the tumor cells don’t express that antigen, they can escape the T cell attack.

MIT researchers have now found a way to overcome that obstacle, using a vaccine that boosts the response of engineered T cells, known as chimeric antigen receptor (CAR) T cells, and also helps the immune system generate new T cells that target other tumor antigens. In studies in mice, the researchers found that this approach made it much more likely that tumors could be eradicated.

A new vaccine boosts the response of engineered CAR-T cells and helps the immune system generate T cells that target other tumor antigens. The researchers found this approach made it more likely that a tumor can be eradicated in mice.

Relationship among bats, parasitic bat flies, and associated pathogens in Korea

Conclusions.

The vectorial role of bat flies should be checked by testing the same pathogen and bacterial organisms by collecting blood from host bats. This study is of great interest in the fields of disease ecology and public health owing to the bats’ potential to transmit pathogens to humans and/or livestock.

Covid is a bat bourne disease from such zoonotic transmission.

Background Bats are hosts for many ectoparasites and act as reservoirs for several infectious agents, some of which exhibit zoonotic potential. Here, species of bats and bat flies were identified and screened for microorganisms that could be mediated by bat flies. Methods Bat species were identified on the basis of their morphological characteristics. Bat flies associated with bat species were initially morphologically identified and further identified at the genus level by analyzing the cytochrome c oxidase subunit I gene. Different vector-borne pathogens and endosymbionts were screened using PCR to assess all possible relationships among bats, parasitic bat flies, and their associated organisms. Results Seventy-four bat flies were collected from 198 bats; 66 of these belonged to Nycteribiidae and eight to Streblidae families.

Scientists Find the Source of a Mysterious Brain Wave That Could Boost Memory and Creativity

In a way, the brain changes its channels as we go about our day to match our internal state of mind to outside requirements—though at any point, the channels can bleed over.

But there’s a mysterious outcast: a frequency called theta waves. They happen while we’re awake or asleep. For decades, these waves have taunted neuroscientists trying to decipher their functions. Theta waves seem to help mice navigate mazes, but also support memory in humans.

It’s not just academic curiosity. Our ability to navigate complex new environments and keep those memories declines with age. It’s especially tough for people with Alzheimer’s disease. By finding the driving source of theta waves, we could potentially enhance them—using neurostimulation or other methods—to slow cognitive decline.

Niacin Increases NAD (Test Results)

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Scientists Have Just Mapped Our Body’s Organs in Exquisite Detail

A consortium of scientists has just published an atlas of remarkable images of three human organs, each vital in their own way, showing how cell types are arranged and interact.

The result: Glittering, kaleidoscopic blueprints lit up by fluorescent dyes that reveal new intimacies about our bodies and reshape our understanding of human biology and disease like never before.

As you can see in the diagram below, researchers generated the cell atlases in three ways.

Ear Infections in Babies and Toddlers

Ear infections in babies and toddlers are extremely common. In fact, according to the National Institutes of Health, five out of six children will experience an ear infection before their third birthday.

“Many parents are concerned that an ear infection will affect their child’s hearing irreversibly—or that an ear infection will go undetected and untreated,” says David Tunkel, M.D., Johns Hopkins Medicine pediatric otolaryngologist (ENT). “The good news is that most ear infections go away on their own, and those that don’t are typically easy to treat.”

Ear infections happen when there is inflammation— usually from trapped bacteria—in the middle ear, the part of the ear connects to the back of the nose and throat. The most common type of ear infection is otitis media, which results when fluid builds up behind the eardrum and parts of the middle ear become infected and swollen.