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Category: biotech/medical – Page 840

Understanding the basics of artificial intelligence in healthcare.

Healthcare spending simply isn’t keeping up. Healthcare systems will struggle to remain viable unless big structural and transformational changes are implemented. Automation, along with artificial intelligence (AI), has the potential to revolutionize healthcare.

Artificial Intelligence in Healthcare is utilized to analyze and avoid illness treatment procedures. AI is employed in many fields of healthcare, including diagnosis, drug research, medication, patient monitoring care centers, and so on.

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The human body reveals compelling evidence of evolution. By examining its intricacies, we uncover remnants of our animal ancestors. One such example is the palmaris longus, a vestigial muscle in the forearm. Although it no longer affects grip strength, it can be removed for reconstructive surgeries. Our outer ear muscles also bear witness to our evolutionary past. While their movement is limited to humans, they once aided early nocturnal mammals in sound localization. Today, electrodes can detect slight muscle activity in response to sudden sounds.

Goosebumps offer another intriguing clue. When we’re cold, tiny muscles connected to body hairs contract, causing the hair to stand upright, and creating bumps on the skin. This response, useful for furry mammals’ insulation, can also be triggered by intense emotions or surprising musical moments in humans. Lastly, the tailbone, or coccyx, composed of fused vertebrae, represents the vestiges of our ancestors’ tails. Although all humans develop a tail during embryonic stages, it regresses and disappears, except in rare cases of a vestigial tail present at birth. These remnants within our bodies provide tangible proof of evolution. Delving into these fascinating traces deepens our understanding of our evolutionary journey and our place in the natural world.

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Busso also said we don’t yet know the long-term effects of these treatments on normal cells or what the long-term impact of killing zombie cells might be. Additionally, because zombie cells play an important role in wound healing, “We don’t want to remove all of them,” he said. “We don’t know the ideal regimen, daily versus weekly versus monthly.”

Hopefully, we won’t have to wait long for answers about the best way to get rid of zombie cells on the skin. “Major breakthroughs and contributions to delaying of the aging process are expected in the near future,” Busso said.

Although it’s still unclear whether zombie cells can be safely and effectively cleared from the skin, it is possible to prevent some zombie cells from forming in the first place. Collins explained that zombie cells are formed as the result of both biological and environmental factors. “The internal factors, like aging or genetic disease, are not so much within our control,” but the external factors can be controlled, she said.

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Oxford Research has reveals how high blood glucose reprograms the metabolism of pancreatic beta-cells in diabetes, acting as a major causal factor of Type 2 diabetes. This is significant because glucose metabolites (chemicals produced when glucose is broken down by cells), rather than glucose itself, have been discovered to be key to the progression of Type 2 diabetes.

With diabetes, the pancreatic beta-cells do not release enough of the hormone insulin, which lowers blood glucose levels. This is because a glucose metabolite damages pancreatic beta-cell function. High blood glucose levels cause an increased rate of glucose metabolism in the beta-cell which leads to a metabolic bottleneck and the pooling of upstream metabolites.

Around 90 percent of global cases of diabetes are Type 2 diabetes (T2D). T2D normally presents in later adult life, and by the time of diagnosis, as much as 50 percent of beta cell function has been lost. In T2D, the beta-cells have a reduced insulin content and the coupling between glucose and insulin release is impaired.

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Continue reading “Epigenetic Age Test #6: My Youngest Data For Horvath, DunedinPACE” | >

The African turquoise killifish is an emerging vertebrate model organism with great potential for aging research due to its naturally short lifespan. Thus far, turquoise killifish aging omic studies using RNA-seq have examined a single organ, single sex and/or evaluated samples from non-reference strains. Here, we describe a resource dataset of ribosomal RNA depleted RNA-seq libraries generated from the brain, heart, muscle, and spleen from both sexes, as well as young and old animals, in the reference GRZ turquoise killifish strain. We provide basic quality control steps and demonstrate the utility of our dataset by performing differential gene expression and gene ontology analyses by age and sex. Importantly, we show that age has a greater impact than sex on transcriptional landscapes across probed tissues. Finally, we confirm transcription of transposable elements (TEs), which are highly abundant and increase in expression with age in brain tissue. This dataset will be a useful resource for exploring gene and TE expression as a function of both age and sex in a powerful naturally short-lived vertebrate model.

The authors have declared no competing interest.

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