The authors evolved antibiotic-resistant Helicobacter pylori in the absence of antibiotics and presence of DNA from antibiotic-sensitive strains. Horizontal gene transfer mediated the molecular reverse evolution of the antibiotic-resistance gene to the antibiotic-sensitive allele, and the authors used theoretical modelling to determine the evolutionary conditions that promote reverse evolution.
Radon, a naturally occurring radioactive gas produced when metals like uranium or radium break down in rocks and soil, is a known cause of lung cancer. Now new research has found exposure to high levels of this indoor air pollutant is associated with an increased risk of another condition in middle age to older female participants with ischemic stroke. The study is published in the January 3, 2024, online issue of Neurology, the medical journal of the American Academy of Neurology. Ischemic stroke is caused by a blockage of blood flow to the brain and is the most common type of stroke.
The condition, called clonal hematopoiesis of indeterminate potential (CHIP), develops when some hematopoietic stem cells, the building blocks for all blood cells, undergo genetic mutations as a person ages. Cells with such mutations replicate more quickly than cells without them. Previous research has shown people with CHIP may have a higher risk of blood cancers like leukemia and cardiovascular disease including stroke.
The study involved 10,799 female participants with an average age of 67. Approximately half of participants had a stroke or blood clots.
Nearly 2 million Americans suffer from type 1 diabetes — a condition that causes drastic spikes or drops in sugar levels and, in turn, dizziness, nausea, and fatigue. It’s a condition that must constantly be monitored, something that a lot of diabetics find mentally exhausting.
One diabetic, Naomi, told the BBC that she couldn’t handle “the physical or mental challenges of diabetes anymore,” and struggled to monitor her blood sugar levels multiple times a day. Naomi’s struggle isn’t unique — it’s called diabetes burnout.
There’s no cure for type 1 diabetes. However, researchers at the University of Arizona have adapted a cancer immunotherapy technique that has produced promising results in treating diabetes (in mice). The researchers engineered immune cells to fight off rogue T cells (immune cells that go haywire and attack the body) that can damage the pancreas, causing type 1 diabetes.
Several techniques currently are used to determine the pace of aging in animals and, to a lesser degree, in humans. However, the techniques used in humans lack accuracy, don’t assess aging in specific organs, are not widely available, and are expensive.
A multi-institutional research team measured the levels of nearly 5,000 human proteins in 5,676 people of all ages who were followed for as long as 15 years in five prospective longitudinal cohorts. Each measured protein was associated with specific organs, based on previous studies: adipose tissue, artery, brain, heart, immune tissue, intestine, kidney, liver, lung, muscle, or pancreas. Combinations of proteins indicated the pace of aging in each organ. Accelerated aging of one organ was found in nearly 20% of people, and accelerated aging of multiple organs was noted in ≈2%. Accelerated aging in a specific organ correlated with risk for developing disease in that organ. For example, people with accelerated heart aging (vs. those without it) had 250% higher risk for developing heart failure, and people with accelerated brain and vascular aging had nearly 60% higher risk for developing Alzheimer disease.
Various tools — from sequencing a person’s genome to measuring gene expression (e.g., the “methylome”) — are becoming available to predict a person’s risk for developing particular diseases. Will these predictions lead to interventions that lower risk? The jury is still out on that question.
In a small group of veterans diagnosed with mild traumatic brain injury, treatment with a psychedelic drug, ibogaine was associated with improvements in daily function and mental health symptoms, a new study out of Stanford found.
“This could be one of the first treatments for traumatic brain injury,” said Dr. Nolan Williams, associate professor of psychiatry at Stanford, and principal study investigator. “I think it’s a moment of hope for veterans and folks with permanent neurological injury.”
The Federal Drug Administration classifies ibogaine as a Schedule I drug, citing “high abuse potential” and “no accepted medical use.” To receive the one-time dose, 30 Special Ops veterans traveled to a treatment site in Mexico where ibogaine use is unregulated.
Using a new technology developed at MIT, diagnosing lung cancer could become as easy as inhaling nanoparticle sensors and then taking a urine test that reveals whether a tumor is present.
A recent study reveals that the monkeypox, or mpox, virus is evolving into multiple strains due to mutations caused by ongoing interactions with the human immune system, suggesting that the virus has been circulating in humans since 2016.
“These observations of sustained MPXV transmission present a fundamental shift to the perceived paradigm of MPXV epidemiology as a zoonosis and highlight the need for revising public health messaging around MPXV as well as outbreak management and control,” write the authors.
A history-making mission to send a commercial lander to the moon is set to carry DNA to the final frontier.