RENGE is a computational method that infers gene regulatory networks using time-series single-cell CRISPR data as input.
Category: biotech/medical – Page 689
Harnessing all-dielectric metamaterials to manipulate the polarization state of light
Polarization is one of the fundamental characteristics of electromagnetic waves. It can convey valuable vector information in sensitive measurements and signal transmission, which is a promising technology for various fields such as environmental monitoring, biomedical sciences, and marine exploration. Particularly in the terahertz frequency range, traditional device design methods and structures can only achieve limited performance. Designing efficient modulator devices for high-bandwidth terahertz waves presents a significant challenge.
Researchers led by Prof. Liang Wu at Tianjin University (TJU), China, have been conducting experiments in the field of all-dielectric metamaterials, specifically focusing on utilizing these materials and their structural design to achieve effective broadband polarization conversion in the terahertz frequency range.
They propose a cross-shaped microstructure metamaterial for achieving cross-polarization conversion and linear-to-circular polarization conversion in the terahertz frequency range. The study, titled “An all-silicon design of a high-efficiency broadband transmissive terahertz polarization convertor,” was published in Frontiers of Optoelectronics.
A new biomarker can better predict meningioma response to radiation
This new biomarker offers insights into how meningioma patients with different gene expression patterns respond differently to treatments.
Michael Levin | Evolution, Basal Cognition and Regenerative Medicine
Talk kindly contributed by Michael Levin in SEMF’s 2023 Interdisciplinary Summer School: https://semf.org.es/school2023/sessions.html#S1TALK ABSTRACTEach of u…
Oncology/Cancer: 2023 Advancements and Breakthroughs
From mRNA technology to T cell engagers, there were a number of advancements in cancer research in 2023.
Study identifies ‘visual system’ protein for circadian rhythm stability
Scientists at the Johns Hopkins University School of Medicine and the National Institutes of Health have identified a protein in the visual system of mice that appears to be key for stabilizing the body’s circadian rhythms by buffering the brain’s response to light. The finding, published Dec. 5 in PLoS Biology, advances efforts to better treat sleep disorders and jet lag, the study authors say.
“If circadian rhythms adjusted to every rapid change in illumination, say an eclipse or a very dark and rainy day, they would not be very effective in regulating such periodic behaviors as sleep and hunger. The protein we identified helps wire the brain during neural development to allow for stable responses to circadian rhythm challenges from day to day,” says Alex Kolodkin, Ph.D., professor in the Johns Hopkins Department of Neuroscience and deputy director for the Institute for Basic Biomedical Sciences.
Kolodkin co-led the study with Samer Hattar, Ph.D., chief of the Section on Light and Circadian Rhythms at the National Institute of Mental Health.
Could Quark Stars be the Engines of Self-Replicating Strange Matter?
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Written & presented by Prof. David Kipping. Edited by Jorge Casas. Special thanks to Dr Sam Gregson (/ @badboyofscience) for fact checking our script.
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THANK-YOU to D. Smith, M. Sloan, L. Sanborn, C. Bottaccini, D. Daughaday, A. Jones, S. Brownlee, N. Kildal, Z. Star, E. West, T. Zajonc, C. Wolfred, L. Skov, G. Benson, A. De Vaal, M. Elliott, B. Daniluk, M. Forbes, S. Vystoropskyi, S. Lee, Z. Danielson, C. Fitzgerald, C. Souter, M. Gillette, T. Jeffcoat, J. Rockett, D. Murphree, T. Donkin, K. Myers, A. Schoen, K. Dabrowski, J. Black, R. Ramezankhani, J. Armstrong, K. Weber, S. Marks, L. Robinson, S. Roulier, B. Smith, J. Cassese, J. Kruger, S. Way, P. Finch, S. Applegate, L. Watson, E. Zahnle, N. Gebben, J. Bergman, E. Dessoi, C. Macdonald, M. Hedlund, P. Kaup, C. Hays, W. Evans, D. Bansal, J. Curtin, J. Sturm, RAND Corp., M. Donovan, N. Corwin, M. Mangione, K. Howard, L. Deacon, G. Metts, G. Genova, R. Provost, B. Sigurjonsson, G. Fullwood, B. Walford, J. Boyd, N. De Haan, J. Gillmer, R. Williams, E. Garland, A. Leishman, A. Phan Le, R. Lovely, M. Spoto, A. Steele, M. Varenka, K. Yarbrough, A. Cornejo, D. Compos, F. Demopoulos, G. Bylinsky, J. Werner, B. Pearson, S. Thayer, T. Edris, A. Harrison, B. Seeley, F. Blood, M. O’Brien, P. Muzyka, E. Loomans, D. Lee, J. Sargent, M. Czirr, F. Krotzer, I. Williams, J. Sattler, J. Smallbon, B. Reese, J. Yoder, O. Shabtay & X. Yao.
REFERENCES
Elon Musk slams media for linking robot attack to Optimus
Industrial mishaps are not rare but caution is prime. Tesla’s CEO Elon Musk has lashed out at the media for sensationalizing an old injury caused by a robot at his Giga Texas factory in Austin, Texas. He claimed that the media was trying to link the incident to his futuristic Optimus robots, which he said would usher in a new era of abundance.
The incident, which happened two years ago, involved a software engineer who was programming software for robots that cut car parts from freshly cast aluminum. While he was working, he was unaware that one of the robots was still active while the other two were disabled for maintenance. The active robot then attacked the engineer, pinning him down and clawing at his back and arm. The attack left a trail of blood on the factory floor, as well as an open wound on the engineer’s left hand.
This E-tongue mimicks human taste and recommends wine with different foods
Scientists pave the way for new culinary frontiers.
This E-tongue can identify four tastes – saltiness, sourness, astringency, and sweetness – in just a tiny bit of food, and uses deep-learning technology to understand taste. It even works well with different kinds of wines.
The E-tongue is like a super tool that can be used in different industries like food, drinks, makeup, and medicine, explained the researchers in a press release by Daegu Gyeongbuk Institute of Science & Technology (DGIST).
“The novel technology developed in this study is an electronic tongue system that integrates sensors and deep learning and measures complex flavors, and it is a sensor-deep-learning technology that can quantitatively evaluate taste, which was difficult in the past,” said Professor Kyung-In Jang from the DGIST Department of Robotics and Mechanical and Electronic Engineering.
One CAR T-Cell Therapy for Blood Cancers?
In the Lord of the Rings, there was “one ring to rule them all.” Now, a team of researchers is developing their own single ruler, an approach to CAR T-cell therapy that could treat all forms and types of blood cancer.
In experiments in mouse models of different blood cancers, the treatment rapidly eliminated tumors, including in mice with acute myeloid leukemia (AML), a difficult-to-treat type of blood cancer for which researchers have struggled to develop effective immunotherapies.
There was also no evidence of serious side effects in the animals. And, finally—and distinctly from the standard approach to current CAR T-cell therapies—it provided the mice with a healthy supply of new blood cells.