Lifeboat Foundation

The powerful animal tranquilizer, xylazine, is being detected more often in the illegal drug supply, but it’s fentanyl that’s killing opioid users, experts warn.

In a significant advance for the treatment of obesity, biotech giant Eli Lilly has announced the results from a trial of retatrutide, which produced a staggering 24.2% weight loss in patients.

Obesity, defined as a body mass index (BMI) of 30 or higher, is a major health issue that has increased significantly over the years. As of today, it affects over 42% of adults in the United States, with 20% of children and adolescents also affected. Worldwide, more than 1 billion people are dealing with the condition, including 650 million adults, 340 million adolescents, and 39 million children.

A new type of ferroelectric polymer that is exceptionally good at converting electrical energy into mechanical strain holds promise as a high-performance motion controller or “actuator” with great potential for applications in medical devices, advanced robotics, and precision positioning systems, according to a team of international researchers led by Penn State.

Mechanical strain, how a material changes shape when force is applied, is an important property for an actuator, which is any material that will change or deform when an external force such as electrical energy is applied. Traditionally, these actuator materials were rigid, but soft actuators such as ferrroelectric polymers display higher flexibility and environmental adaptability.

The research demonstrated the potential of ferroelectric polymer nanocomposites to overcome the limitations of traditional piezoelectric polymer composites, offering a promising avenue for the development of soft actuators with enhanced strain performance and mechanical energy density. Soft actuators are especially of interest to robotics researchers due to its strength, power and flexibility.

I believe that homelessness is often seen in America or other parts of the world as bad but with Finland they have found a housing first approach which has stopped nearly all homelessness there. I believe also regenerative medicine and lots of transhumanistic approaches to medicine would help end their aging and even repair their body if needed. Also if we research the brain we can finally discover and repair genes throughout the body essentially bringing them back near perfect and beyond. Along with ethical approaches towards a more cultural relativistic approach to all humans could show everyone how to coexist. It is still a problem of aging though which is still curable and in extreme cases will be eventually solved in the future. I think with a more comprehensive understanding of all transhumansistic medicine it would be possible to save all lives so no one is left behind.

OK, so the Finns are more generous and just shell out a lot more to help the homeless, right? Actually not. The Finns are simply smarter.

Instead of abandoning the homeless, they housed them. And that led to an insight: people tend to function better when they’re not living on the street or under a bridge. Who would have guessed?

Continue reading “How Finland managed to virtually end homelessness” »

A study led by researchers at Sanford Burnham Prebys has found that in young women, certain genetic mutations are associated with treatment-resistant breast cancer. These mutations are not linked to treatment-resistant breast cancer in older women. The findings, published in the journal Science Advances, could help improve precision medicine and suggest a brand-new way of classifying breast cancer.

“It’s well established that as you get older, you’re more likely to develop cancer. But we’re finding that this may not be true for all cancers depending on a person’s genetic makeup,” says senior author Svasti Haricharan, Ph.D., an assistant professor at Sanford Burnham Prebys. “There may be completely different mechanisms driving cancer in younger and older people, which requires adjusting our view of aging and cancer.”

The research primarily focused on ER+/HER2-breast cancer, which is one of the most common forms of the disease. It is usually treated with hormonal therapies, but for some patients, these treatments don’t work. About 20% of tumors resist treatment from the very beginning, and up to 40% develop resistance over time.

Summary: A ‘smart hand exoskeleton’, a custom-made robotic glove, can aid stroke patients in relearning dexterity-based skills like playing music. The glove, equipped with integrated tactile sensors, soft actuators, and artificial intelligence, can mimic natural hand movements and provide tactile sensations.

By applying machine learning, the glove can distinguish between correct and incorrect piano play, potentially offering a novel tool for personalized rehabilitation. Although the current design focuses on music, the technology holds promise for a broader range of rehabilitation tasks.

And he mentions Internatioan Aging Systems where you can legally order Rapamycin but I would have to know what experience people have had with them and their product first myself.

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In this video Pelton talks all about rapamycin, its history, how it works, dosage and timing. He also talks about where you can get rapamycin online.

Continue reading “Rapamycin — All You Need To Know & Get Started | Dr Ross Pelton Ep1” »

Another potentially game-changing discovery has come out of the lab of Feng Zhang, PhD. This time, they uncovered the first programmable RNA-guided system in eukaryotes. Just a few months ago, the Zhang lab adapted a contractile injection system, found naturally in bacteria, that deliver protein payloads to target human cells.

In this recent work, Zhang’s team describes how the system—based on the Fanzor protein—uses RNA as a guide to target DNA precisely, and that Fanzor can be reprogrammed to edit the genome of human cells. Additionally, the compact Fanzor systems have the potential to be more easily delivered to cells and tissues as therapeutics than CRISPR/Cas systems, and further refinements to improve their targeting efficiency could make them a valuable new technology for human genome editing.

The research is published in Nature, in the paper, “Fanzor is a eukaryotic programmable RNA-guided endonuclease.”

Historically, colonialism was initially predicated on a simple “rob and take home” concept. During the first colonialist age, the superpowers of that era (primarily England and France) used to send their agents overseas to obtain precious goods at very low prices, and to bring those goods back to their home countries, selling them at very high prices (today, such practices are far from being obsolete!). Such policies were often socially detrimental, especially when they boosted the use of drugs (e.g., stimulating opium dependence in several Chinese provinces). In many cases, colonialist policies lead to conflicts and wars (in order to ensure control over certain regions). In most cases, nothing positive remained for the colonized populations, since the colonialist behaviors primarily engaged populations with a culture based on robbery and exploitation – not to advance civil rights. Regarding the “new world” (America’s two continents), colonialists have also invaded these territories, stealing the land and natural resources from native inhabitants, and exterminating these inhabitants by any means. During the last age of colonialism (up to the 20th Century), the practice of depredation continued, in many cases retarding or preventing the development of colonized countries, notwithstanding the abundance of natural riches, from which native peoples could never benefit.

Ok, I am listening now to your classical objections. I, for one, have noted this several times while discussing space colonization: in the solar system there are no native intelligent beings, therefore we would not steal anything from anyone, by colonizing territories on the Moon, Mars, Jupiter Moons and beyond. Of course, I am talking about the very essential part of colonialism: to take resources and bring them home. In our cases, to take asteroid and exo-planetary resources from the Moon, asteroids, Mars and beyond, and bring them on Earth surface – why would this be harmful?

Space colonialism would be both a dangerous and harmful undertaking for several reasons.