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Category: biotech/medical – Page 546

Human trials to begin for new teeth regeneration drug
Scientists at Kyoto University Hospital will conduct the first human trial of the drug from September 2024 to August 2025. In tests on ferrets and mice, the drug worked with no notable side effects, Popular Mechanics reported.
The drug will be used on 30 men between 30–64 who are missing at least one molar. From there, researchers will expand the study to those with partial edentulism, or those missing one to five permanent teeth.

Scientists discover that people who live past 90 have key differences in their blood
Centenarians have become the fastest-growing demographic group in the world, with numbers approximately doubling every 10 years since the 1970s.
Many researchers have sought out the factors and contributors that determine a long and healthy life. The dissolution isn’t new either, with Plato and Aristotle writing about the ageing process over 2,300 years ago.
Understanding what is behind living a longer life involves unravelling the complex interplay of genetic predisposition and lifestyle factors and how they interact.
‘Space hairdryer’ regenerates heart tissue in study | BBC News
Gentle shockwaves can help regenerate heart tissue.

Eating More Fruits and Vegetables may Lead to Optimal Sleep Duration
Good health depends on a healthy diet and sufficient exercise and sleep. There are clear associations among these components; for example, good nutrition provides energy for exercise, and many people report that getting enough exercise is important to their ability to get enough sleep. So how might nutrition affect sleep?
A new study looks at the connection between fruit and vegetable intake and sleep duration. The research, by a team from Finland’s University of Helsinki, National Institute for Health and Welfare, and Turku University of Applied Sciences, is published in Frontiers in Nutrition.
Why sleep is important and how it works Sleep gives our bodies the chance to rest and recover from wakeful activity. Our hearts, blood vessels, muscles, cells, immune systems, cognitive abilities, and memory-making abilities depend on regular, healthy sleep for optimal functioning, and a 2019 study suggests that sleep is important for repairing DNA damage that occurs during wakefulness.
AI robot makes knee replacement surgeries more precise, affordable
This surgical robot enhances precision, safety, and affordability in joint replacements:
Indian firm’s surgical robot streamlines orthopedic joint-replacement procedures with precise planning and real-time adjustments.

Scientists Reverse Alzheimer’s Synapse Damage in Mice
Scientists in Japan say they have reversed the signs of Alzheimer’s disease in lab mice by restoring the healthy function of synapses, critical parts of neurons that shoot chemical messages to other neurons.
The secret was developing a synthetic peptide, a small package of amino acids — a mini-protein, if you will — and injecting it up the nostrils of the mice, in an experiment they detailed in a study published in the journal Brain Research.
Needless to say, mice are very different from humans. But if the treatment successfully survives the gauntlet of clinical studies with human participants, it could potentially lead to a new treatment for Alzheimer’s disease, a tragic degenerative condition that burdens tens of millions of people around the world.

Scientists Discover Unexpected Importance of “Time Cells” for Complex Learning
Researchers at the University of Utah Health have discovered that “time cells” in mice are crucial for learning tasks where timing is critical. These cells change their firing patterns as mice learn to distinguish between timed events, suggesting a role beyond just measuring time. This finding could help in the early detection of neurodegenerative diseases like Alzheimer’s by highlighting the importance of the medial entorhinal cortex (MEC), which is among the first brain regions affected by such diseases.
Researchers at the University of Utah Health found that “time cells” in mice adapt to learning timed tasks, a discovery that could aid early Alzheimer’s detection by monitoring changes in a key brain region.
Our perception of time is crucial to our interaction with and understanding of the world around us. Whether we’re engaging in a conversation or driving a car, we need to remember and gauge the duration of events—a complex but largely unconscious calculation running constantly beneath the surface of our thoughts.

Researchers investigate the impacts of space travel on astronauts’ eye health
As space travel becomes more common, it is important to consider the impacts of space flight and altered gravity on the human body. Led by Dr. Ana Diaz Artiles, researchers at Texas A&M University are studying some of those impacts, specifically effects on the eye. The findings are published in the journal npj Microgravity.

Principal component-based clinical aging clocks identify signatures of healthy aging and targets for clinical intervention
Using a dimensionality reduction approach, Fong et al. generated a clinical aging clock (PCAge) that delineates healthy and unhealthy aging trajectories. They provide a streamlined version (LinAge) that maintains predictive power, and they demonstrate how the clock can be tailored to available data using the CALERIE study.