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Researchers at the Francis Crick Institute and Aalborg University in Copenhagen have shown that changes can be detected in blood tests up to eight years before a diagnosis of Crohn’s disease and up to three years before a diagnosis of ulcerative colitis.

This means the beginnings of inflammatory diseases start a long time before symptoms occur, and in the future may provide an opportunity for doctors to take preventative action before symptoms begin, or prescribe medication when it will be most effective.

Crohn’s disease and ulcerative colitis are collectively known as inflammatory bowel diseases (IBD). They are incurable conditions which involve excessive inflammation in the gut, leading to symptoms like abdominal pain and diarrhea. Early diagnosis and treatment are key to improving outcomes, but nearly a quarter of the 25,000 people diagnosed each year in the UK wait over a year.

Oak Ridge National Laboratory’s research in quantum biology and AI has significantly improved the efficiency of CRISPR Cas9 genome editing in microbes, aiding in renewable energy development.

Scientists at Oak Ridge National Laboratory (ORNL) used their expertise in quantum biology, artificial intelligence, and bioengineering to improve how CRISPR Cas9 genome editing tools work on organisms like microbes that can be modified to produce renewable fuels and chemicals.

CRISPR is a powerful tool for bioengineering, used to modify genetic code to improve an organism’s performance or to correct mutations. The CRISPR Cas9 tool relies on a single, unique guide RNA.

In an interesting revelation, a collaborative team of researchers across various institutions in London has shown that rocket scientists and neurosurgeons, who are often held on a high pedestal for their superior intellect are, in fact, no smarter than the general public, BBC reported.

When failing to complete day-to-day tasks, one often comes across the term “It’s not rocket science”. The phrases that have been used by the public at large tacitly imply that rocket science or brain surgery is not a menial job and requires an individual of a higher intellect. Interestingly, it was a team of neurosurgeons and those involved in studying the human brain who decided to probe whether this held true.

Osteonecrosis is a disease caused by reduced blood flow to bones in the joints. In people with healthy bones, new bone is always replacing old bone. In osteonecrosis, the lack of blood causes the bone to break down faster than the body can make enough new bone. The bone starts to die and may break down.

You can have osteonecrosis in one or several bones. It is most common in the upper leg. Other common sites are your upper arm and your knees, shoulders and ankles. The disease can affect men and women of any age, but it usually strikes in your thirties, forties or fifties.

At first, you might not have any symptoms. As the disease gets worse, you will probably have joint pain that becomes more severe. You may not be able to bend or move the affected joint very well.

Treating mental disorders with fewer side effects

Now, researchers have managed to genetically modify yeast cells to produce drugs for mental disorders such as schizophrenia with fewer side effects.

“Development of medicines from natural plant substances is widely used. However, since plants do not produce these substances to fight human diseases, there is often a need to modify them to make them more effective and safe,” said Michael Krogh Jensen, a senior researcher at DTU Biosustain and co-founder of the biotech company Biomia.

The challenge of measuring adult neurogenesis is difficult, but it’s not impossible. A big part of the solution is knowing what to measure and where. While this new study was performed on rats—and therefore may be a poor predictor of what we’ll see in humans—it can direct future research by showing neuroscientists where to look and what to look for.

And unlike the hard problem of consciousness, unraveling the mysteries of adult neurogenesis may have clinical applications. Better the lifecycle of neurons may reveal how neurological disorders such as Parkinson’s and Alzheimer’s disease emerge. There’s even research linking disorders such as depression and anxiety to neurogenesis activity.

This knowledge may lead to new treatments, but if not, it could also reveal a better understanding of how our lifestyles and environments support brain health and regeneration throughout human life.