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Category: biotech/medical – Page 510

Vitamin D Alters Mouse Gut Bacteria to give Better Cancer Immunity

Researchers at the Francis Crick Institute, the National Cancer Institute (NCI) of the U.S. National Institutes of Health (NIH) and Aalborg University in Denmark have found that vitamin D encourages the growth of a type of gut bacteria in mice which improves immunity to cancer.

Reported today in Science, the researchers found that mice given a diet rich in vitamin D had better immune resistance to experimentally transplanted cancers and improved responses to immunotherapy treatment. This effect was also seen when gene editing was used to remove a protein that binds to vitamin D in the blood and keeps it away from tissues.

Surprisingly, the team found that vitamin D acts on epithelial cells in the intestine, which in turn increase the amount of a bacteria called Bacteroides fragilis. This microbe gave mice better immunity to cancer as the transplanted tumours didn’t grow as much, but the researchers are not yet sure how.

Superintelligence: Paths, Dangers, Strategies

Since the release of ChatGPT in November 2022, artificial intelligence (AI) has both entered the common lexicon and sparked substantial public intertest. A blunt yet clear example of this transition is the drastic increase in worldwide Google searches for ‘AI’ from late 2022, which reached a record high in February 2024.

You would therefore be forgiven for thinking that AI is suddenly and only recently a ‘big thing.’ Yet, the current hype was preceded by a decades-long history of AI research, a field of academic study which is widely considered to have been founded at the 1956 Dartmouth Summer Research Project on Artificial Intelligence.1 Since its beginning, a meandering trajectory of technical successes and ‘AI winters’ subsequently unfolded, which eventually led to the large language models (LLMs) that have nudged AI into today’s public conscience.

Alongside those who aim to develop transformational AI as quickly as possible – the so-called ‘Effective Accelerationism’ movement, or ‘e/acc’ – exist a smaller and often ridiculed group of scientists and philosophers who call attention to the inherent profound dangers of advanced AI – the ‘decels’ and ‘doomers.’2 One of the most prominent concerned figures is Nick Bostrom, the Oxford philosopher whose wide-ranging works include studies of the ethics of human enhancement,3 anthropic reasoning,4 the simulation argument,5 and existential risk.6 I first read his 2014 book Superintelligence: Paths, Dangers, Strategies7 five years ago, which convinced me that the risks which would be posed to humanity by a highly capable AI system (a ‘superintelligence’) ought to be taken very seriously before such a system is brought into existence. These threats are of a different kind and scale to those posed by the AIs in existence today, including those developed for use in medicine and healthcare (such as the consequences of training set bias,8 uncertainties over clinical accountability, and problems regarding data privacy, transparency and explainability),9 and are of a truly existential nature. In light of the recent advancements in AI, I recently revisited the book to reconsider its arguments in the context of today’s digital technology landscape.

The Complex Social Lives of Viruses

This simplicity was what attracted many scientists to viruses in the first place, said Marco Vignuzzi, a virologist at the Singapore Agency for Science, Research and Technology Infectious Diseases Labs. “We were trying to be reductionist.”

That reductionism paid off. Studies on viruses were crucial to the birth of modern biology. Lacking the complexity of cells, they revealed fundamental rules about how genes work. But viral reductionism came at a cost, Vignuzzi said: By assuming viruses are simple, you blind yourself to the possibility that they might be complicated in ways you don’t know about yet.

For example, if you think of viruses as isolated packages of genes, it would be absurd to imagine them having a social life. But Vignuzzi and a new school of like-minded virologists don’t think it’s absurd at all. In recent decades, they have discovered some strange features of viruses that don’t make sense if viruses are lonely particles. They instead are uncovering a marvelously complex social world of viruses. These sociovirologists, as the researchers sometimes call themselves, believe that viruses make sense only as members of a community.

Tuberous Sclerosis

Tuberous sclerosis is a rare genetic disease that causes benign tumors to grow in the brain and other organs. The disease can be mild, or it can cause severe disabilities. Tuberous sclerosis has no cure, but treatments can help symptoms. More info here.

Tuberous sclerosis (TSC) is a rare genetic disease. It causes benign tumors in the brain and other organs. Learn about symptoms and what can help.

Frozen human brain tissue works perfectly when thawed 18 months later

In good news for future animation figureheads, there might be a new way to revive frozen brains without damaging them. Scientists in China have developed a new chemical concoction that lets brain tissue function again after being frozen.

Freezing is effective at keeping organic material from decomposing, but it still causes damage. As the water inside turns to ice, the crystals tear apart the cells. That’s why frozen meat or fruit goes a bit mushy after it’s defrosted – but a bigger problem is that it also happens with organs or tissues chilled for transplant or research.

For the new study, scientists at Fudan University in China experimented with various chemical compounds to see which ones might work to preserve living brain tissue during freezing. They started by testing out promising chemicals on brain organoids – small, lab-grown lumps of brain tissue that develop into different types of related cells.