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Category: biotech/medical – Page 509

Long-term data from a study implemented by the # NIH-funded International Maternal Pediatric Adolescent AIDS Clinical Trials Network showed very early antiretroviral therapy (ART) for infants who acquired HIV in utero enabled some infants to sustain viral suppression for more than two years.

Very early ART for in-utero HIV-1 can achieve sustained virological suppression in association with biomarkers indicating restricted HIV-1 reservoirs by age 2 years, which might enable potential ART-free remission.

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However, when major genome rearrangements occur — like the ones that the team was seeing in the skate’s DNA — boundaries can be lost, and the relative positions of genes on chromosomes can change. As a result, “some enhancers can provide instructions to the wrong gene,” explained Dario Lupiáñez, an evolutionary biologist at the Max Delbrück Center in Berlin and one of the senior authors of the study.

It seemed possible that the changes in the 3D architecture of the skate genome might have disrupted the ancient blocks of genes the skates inherited from their sharklike ancestors, affecting the genes’ function. “We were trying to look at whether some genome rearrangements in the little skate actually break these blocks,” said Ferdinand Marlétaz, a genomicist at University College London and co-first author of the study.

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An international team led by researchers at the University of Toronto has uncovered over 100 genes that are common to primate brains but have undergone evolutionary divergence only in humans—and which could be a source of our unique cognitive ability.

The researchers, led by Associate Professor Jesse Gillis from the Donnelly Center for Cellular and Biomolecular Research and the department of physiology at U of T’s Temerty Faculty of Medicine, found the genes are expressed differently in the brains of humans compared to four of our relatives—chimpanzees, gorillas, macaques and marmosets.

The findings, published in Nature Ecology & Evolution, suggest that reduced , or tolerance to loss-of-function mutations, may have allowed the genes to take on higher-level cognitive capacity. The study is part of the Human Cell Atlas, a global initiative to map all to better understand health and disease.

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Per-and polyfluoroalkyl substances (PFAS), manufactured chemicals used in products such as food packaging and cosmetics, can lead to reproductive problems, increased cancer risk and other health issues. A growing body of research has also linked the chemicals to lower bone mineral density, which can lead to osteoporosis and other bone diseases. But most of those studies have focused on older, non-Hispanic white participants and only collected data at a single point in time.

Now, researchers from the Keck School of Medicine of USC have replicated those results in a of two groups of young participants, primarily Hispanics, a group that faces a heightened risk of disease in adulthood.

“This is a population completely understudied in this area of research, despite having an increased risk for bone disease and osteoporosis,” said Vaia Lida Chatzi, MD, Ph.D., a professor of population and public health sciences at the Keck School of Medicine and the study’s senior author.

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On the internet, nothing is safe — not even your DNA, apparently.

That’s the dystopian lesson from the commercial genetic testing company 23andMe, which disclosed on Friday in a regulatory filing that hackers managed to access information on about 14,000 users or 0.1 percent of its customer user base.

But the problem goes beyond this relatively small number of people. Because the website allows users to share DNA information with other users in order to find relatives, the true number impacted is orders of magnitude larger — with about 6.9 million customers having their personal information compromised, according to TechCrunch. Big yikes on that figure, because it affects something like half of the 14 million users at 23andMe.

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“It is particularly challenging, expensive, and time-consuming to find polar bears in the Arctic, let alone count them and understand how they are coping with climate change,” said Dr. Melanie Lancaster.

Can scientists use DNA from polar bear footprints to help improve conservation efforts during this age of climate change? This is what a recent study published in Frontiers in Conservation Science hopes to address as a team of international researchers have developed a novel tool designed to use DNA from polar bear footprint skin cells with the goal of tracking the large mammals without the need to capture them, which often risks the safety of both the polar bears and their human captors in the process. This study holds the potential to develop new methods in tracking animals whose populations are at risk as climate change continues to warm the planet.

Polar bear near Utqiagvik, Alaska in May 2022. (Credit: Elisabeth Kruger, World Wildlife Fund)

The World Wildlife Fund (WWF) currently estimates 22,000–31,000 polar bears worldwide, which are divided into 19 distinct sub-populations while classifying a “vulnerable” risk to polar bears on the international scale, along with having this same classification for Greenland, Denmark, and Norway. Additionally, they are polar bears are classified as “threatened” in the United States, “recovering” in Russia, and “special concern” in Canada, the last of which 60–80 percent of polar bears reside. As noted, capturing or trapping polar bears can be extremely dangerous, with previous methods using low-flying helicopters to dart polar bears.

Continue reading “Snowy Footprints as DNA Gold Mines: A New Frontier in Polar Bear Research” | >

Scientists have created tiny, self-assembling robots made from human cells that could one day repair damaged skin and tissue.

These tiny biological machines, called Anthrobots, are made from human tracheal cells without any genetic modification. Lab dish experiments revealed they can encourage neurons, or nerve cells, to grow in damaged tissue.

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Recent technological advancements have opened invaluable opportunities for assisting people who are experiencing impairments or disabilities. For instance, they have enabled the creation of tools to support physical rehabilitation, to practice social skills, and to provide daily assistance with specific tasks.

Researchers at Meta AI recently developed a promising and non-invasive method to decode speech from a person’s brain activity, which could allow people who are unable to speak to relay their thoughts via a computer interface. Their proposed method, presented in Nature Machine Intelligence, merges the use of an imaging technique and machine learning.

“After a stroke, or a brain disease, many patients lose their ability to speak,” Jean Remi King, Research Scientist at Meta, told Medical Xpress. “In the past couple of years, major progress has been achieved to develop a neural prosthesis: a device, typically implanted on the motor cortex of the patients, which can be used, through AI, to control a computer interface. This possibility, however, still requires brain surgery, and is thus not without risks.”

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With a processor that has fewer qubits, IBM has improved error correction, paving the way for the use of these processors in real life.

IBM has unveiled its much-awaited 1,000+ qubit quantum processor Condor, alongside a utility-scale processor dubbed IBM Quantum Heron at its Quantum Summit in New York. The latter is the first in the series of utility-scale quantum processors that IBM took four years to build, the company said in a press release.

Quantum computers, considered the next frontier of computing, have locked companies big and small in a race to build the platform that everybody would want to use to solve complex problems in medicine, physics, mathematics, and many more.

Continue reading “IBM finally unveils quantum powerhouse, a 1,000+ qubit processor” | >