Lifeboat Foundation

As researchers, developers, policymakers and others grapple with navigating socially beneficial advanced technology transitions — especially those associated with artificial intelligence, DNA-based technologies, and quantum technologies — there are valuable lessons to be drawn from nanotechnology. These lessons underscore an urgent need to foster collaboration, engagement and partnerships across disciplines and sectors, together with bringing together people, communities, and organizations with diverse expertise, as they work together to realize the long-term benefits of transformative technologies.

Scientists have developed a novel approach that allows stem cells to be turned into retinal ganglion cells that are capable of migrating and surviving in the eye’s retina. This approach presents a promising new treatment strategy for diseases like glaucoma, in which the loss of retinal ganglion cells caused by the disease leads to irreversible vision loss.

Glaucoma is one of the leading causes of blindness worldwide, and vision loss, due to the loss of retinal ganglion cells (RGCs), cannot currently be reversed with any treatment. Some studies have looked at replacing RGCs through cell transplants, but this process is still in the research and development stage and fraught with limitations that highlight a need for a more precise manner of effectively repopulating these cells in the retina. Now, a multidisciplinary team led by researchers at the Schepens Eye Research Institute of Mass Eye and Ear has identified a promising new strategy for glaucoma cell replacement therapy.

In their new study, researchers changed the microenvironment in the eye in a way that enabled them to take stem cells from blood and turn them into retinal ganglion cells that were capable of migrating and surviving into the eye’s retina. They conducted their study on the adult mouse retina, but the work’s implications could one day be applied to human retina, according to the researchers who published their findings November 6th in Proceedings of the National Academy of Sciences.

High-intensity interval training (HIIT) has become very popular; alternating short periods of intense anaerobic exercise with recovery periods, it is designed to help to decrease body fat, increase strength and endurance, and improve healthspan in protocols that last approximately half an hour.

But these days, even finding half an hour can be tricky – enter CAROL Bike, an exercise bike designed around Reduced Exertion HIIT (REHIT) and AI-personalization, meaning an effective workout can be delivered in just 5 minutes.

Continue reading “Improving healthspan and longevity can be just like riding a bike” »

Indicine cattle make up half of all cattle populations worldwide. Using a large genomic dataset, this study finds historic migrations and extensive introgression with domestic and wild bovine species has facilitated this species physiological adaptation to extreme environments.

Target validation is a crucial step in pre-clinical drug discovery workflows that builds confidence on the identification of a genetic target as relevant to a disease. With recent advancements, CRISPR serves as a particularly powerful tool for this process, as it enables researchers to accurately modify genes and determine their function in a variety of experimental systems.

One scientist leveraging CRISPR gene editing in this way is Dr. Panos Zalmas, Head of the Open Targets Validation Lab based at the Wellcome Sanger Institute, whose work focuses on discovering and validating new putative disease targets for the development of safe and effective medicines.

In this SelectScience^® interview, we speak with Zalmas to learn how he is working to improve the rate of target adoption into drug discovery pipelines across therapy areas such as oncology, neurodegeneration, and immunology and inflammation. Here, Zalmas explains the importance of gene editing in his target validation workflows and highlights how CRISPR technologies in particular are key to the success of drug discovery.

A new AI system, Sturgeon, is redefining brain tumor surgeries.

Sturgeon is a pretrained neural network that uses incremental results from nanopore sequencing to rapidly classify central nervous system tumours and can be used to aid critical decision-making during surgery.

The notion of black holes is one that invokes terror and dread. They’re inescapable! They devour everything! Nothing ever comes out!

The accuracy of these beliefs falls on the spectrum of debatable to incorrect. And a pair of physicists has now calculated how proverbial blood might be wrung from the black hole stone. According to Zhan-Feng Mai and Run-Qiu Yang of Tianjin University in China, teeny tiny black holes could theoretically be used as a source of power.

Their calculations find that these ultradense objects could work as rechargeable batteries and nuclear reactors, providing energy on the scale of gigaelectronvolts.

Yes, if it’s quality life this is good and maybe even use this as an example of helping humans live longer and why not cats?

For the first time, the FDA has indicated a willingness to endorse a longevity drug.

That’s good news. Maybe there’s gonna be fewer super bugs springing up.

Researchers have developed a method that identifies bacteria easily, cheaply and more precisely than before. This can help reduce use of antibiotics.

Far too many antibiotics are used around the world. As a result, bacteria are becoming resistant.

Continue reading “Researchers develop faster, cheaper, and more precise method for identifying bacteria” »