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Category: biotech/medical – Page 379

A supersonic drone that will be propelled by a revolutionary new engine has taken to the skies for the first time. When Venus Aerospace’s aircraft does go supersonic on a later date, it will be powered by a Rotating Detonation Rocket Engine (RDRE).

Supersonic drones may sound like something bleeding edge, but they’re surprisingly old hat as a basic concept. As far back as the early 1950s, the US Air Force was fielding remote-controlled supersonic jets for targets to test air defenses, as platforms for reconnaissance in dangerous areas, or as weapons armed with conventional or nuclear warheads.

However, the one thing they’ve all had in common over the past 75 years was a jet engine for propulsion to boost them past Mach 1. In recent years, advances in avionics, aerodynamics, and autonomous systems have allowed uncrewed aircraft to expand their roles, but at their heart, they were still jet propelled.

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Researchers at Tel Aviv University have developed a new treatment course for patients with metastasizing breast cancer, using medication already on the market.

Based on tissue samples from American and Israeli patients and using an animal model, the researchers from the Faculty of Medical and Health Sciences showed that a combination of existing drugs can hinder the spread of cancer to the bones, thereby improving the chances of survival.

More than 75 percent of patients with metastatic breast cancer see it spread to the bone.

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The first patient to receive a kidney transplanted from a genetically modified pig has fared so well that he was discharged from the hospital on Wednesday, just two weeks after the groundbreaking surgery.

The transplant and its encouraging outcome represent a remarkable moment in medicine, scientists say, possibly heralding an era of cross-species organ transplantation.

Two previous organ transplants from genetically modified pigs failed. Both patients received hearts, and both died a few weeks later. In one patient, there were signs that the immune system had rejected the organ, a constant risk.

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Summary: Researchers unveiled a novel approach to combat Alzheimer’s disease by activating microglia, the brain’s immune cells, to devour amyloid beta plaques, a hallmark of the condition. This study highlights the potential of using immunotherapy to not only tackle Alzheimer’s but also other neurodegenerative diseases characterized by harmful protein accumulations.

The team’s method involves using an antibody to stimulate microglia into clearing these plaques, offering a promising alternative to current treatments that directly target amyloid beta and might cause side effects like ARIA. This breakthrough paves the way for new therapeutic strategies that harness the immune system to fight the devastating effects of Alzheimer’s and possibly other diseases like Parkinson’s and ALS.

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This post is also available in: he עברית (Hebrew)

Analyzing and storing large amounts of data requires a lot of energy, so the future of technology might hold a different approach to data storage. At least, that is what Professor Søren Brunak from the University of Copenhagen thinks.

Brunak states that while Denmark is one of the best in the world at health data, analyzing and storing huge amounts of health data comes at a climate cost. “We have begun to consider the carbon footprint of bioinformatics and CO2 emissions resulting from data analysis,” he adds.

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To engineer proteins with useful functions, researchers usually begin with a natural protein that has a desirable function, such as emitting fluorescent light, and put it through many rounds of random mutation that eventually generate an optimized version of the protein.

This process has yielded optimized versions of many important proteins, including green fluorescent protein (GFP). However, for other proteins, it has proven difficult to generate an optimized version. MIT researchers have now developed a computational approach that makes it easier to predict mutations that will lead to better proteins, based on a relatively small amount of data.

Using this model, the researchers generated proteins with mutations that were predicted to lead to improved versions of GFP and a protein from adeno-associated virus (AAV), which is used to deliver DNA for gene therapy. They hope it could also be used to develop additional tools for neuroscience research and medical applications.

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The neurosurgeon Sergio Canavero announced in 2015 that he could soon be capable of performing the world’s first human head transplant procedure. This would mean that it would be possible to remove someone’s head, and graft it onto the neck and shoulders of another person. As of yet, this has only been performed on cadavers and not on living humans.

But suppose you want to keep the face that you’ve already got? Or have grown tired of the body you inhabit? Could it ever be possible to switch brains between bodies instead?

Emma Stone recently won her second Oscar for her performance in the brilliantly surreal comedy Poor Things. In the film, Stone’s character, Bella Baxter, receives a brain transplant from her surviving unborn child after killing herself. The surgery is performed by experimental scientist Dr Godwin Baxter (played by Willem Dafoe).

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