Wagner et al. demonstrate that RNase H1 only removes a subset of R-loops in vivo. In yeast, overexpressed RNH1 acts more frequently at dysregulated R-loops and infrequently, if at all, at other RNA-DNA hybrids. Endogenous Rnh1 is induced in a Rad53-dependent manner at transcription-replication conflicts to promote replication completion.
Why does cancer sometimes recur even after successful treatment, or why do some bacteria survive despite the use of powerful antibiotics? One of the key culprits identified is “biological noise”—random fluctuations occurring inside cells.
Even when cells share the same genes, the amount of protein varies in each, creating “outliers” that evade drug treatments and survive. Until now, scientists could only control the average values of cell populations; controlling the irregular variability of individual cells remained a long-standing challenge.
A joint research team—led by Professor Jae Kyoung Kim (Department of Mathematical Sciences, KAIST), Professor Jinsu Kim (Department of Mathematics, POSTECH), and Professor Byung-Kwan Cho (Graduate School of Engineering Biology, KAIST)—has theoretically established a “noise control principle.” Through mathematical modeling, they have found a way to eliminate biological noise and precisely govern cellular destiny.
Best advice is simply disinfect with vinegar because it kills it on contact.
The fungal species Candida auris is spreading across the globe, and gaining in virulence, according to a new review by a Hackensack Meridian Center for Discovery and Innovation (CDI) scientist and colleagues.
But there are strategies available and underway to combat the invasive and drug-resistant germ, says the work in Microbiology and Molecular Biology Reviews.
The paper summarizes and analyzes the latest developments—and needs—in mycology in 2025. Neeraj Chauhan, Ph.D., of the CDI, is co-author with Anuradha Chowdhary, Ph.D., of the Medical Mycology Unit at the Vallabhbhai Patel Chest Institute at the University of Delhi, who is a global leader in identifying and combating fungal threats, and was one of the first scientists to identify C. auris as a major public health threat in India in 2014. Chowdhary is also a visiting researcher at the CDI.
Basically every year 1 billion people get infected by influenza causing extreme resource shortages still it is getting better to keep the death count down with vaccines but still its potential is still very dangerous and is not quite contained. Along with the super k version of influenza causing a spike in cases globally now. I still think that we need better protection against certain diseases so the resources are not drained globally. Perhaps we can use tricorder like devices on our phones that essentially heal us from diseases which I believe radio nanotransfection could lead to breakthroughs in the future.
Credit: WHO / Lindsay Mackenzie.
Influenza, or the flu, is both a seasonal and a pandemic virus. Every year, mainly during the winter season, seasonal influenza infects as many as 1 billion people. This makes it one of the most common infectious respiratory viruses, after the common cold. Thankfully, the WHO Global Influenza Surveillance and Response System, or GISRS, monitors what viruses are circulating and twice a year recommends which viruses to target in the flu vaccine for the upcoming season. The flu vaccine is the best way to prevent infection and may reduce symptoms if you do get the flu. For those who are more vulnerable to flu, what we call ‘high risk groups’, the vaccine can save your life. Good hygiene practices can also reduce the risk of infection (for more information, see the factsheet here ). Thankfully, although there are hundreds of millions of cases every year, the vast majority of these are not serious. Nevertheless, WHO estimates that there are 3 to 5 million cases of severe illness and between 290 000 to 650 000 respiratory deaths annually.
By Simarro Blasco, J. L., et al. (2025). Biomedicines, 13(12), 3049. 📖Read the full text: https://brnw.ch/21wYJvv.
Large clinical study of 1,800+ women with lipedema identifies key clinical signs and frequent comorbidities, supporting a systemic, connective-tissue–based understanding of the disease.
Background/Objectives: Lipedema is a chronic disorder that affects almost exclusively women and is characterized by bilateral, symmetrical accumulation of subcutaneous fat, typically in the buttocks, hips, and lower limbs, and in some cases the arms.
Harnessing antibodies found in patients with lupus, researchers test a new cancer therapy that turns autoimmune responses against tumor cells in mice, suggesting similar approaches could be integrated into immunotherapy regimens.
Learn more in Science Signaling.
Delivery of autoimmune disease–associated antibodies activates the immune system to fight glioblastomas.
Uruski, P., Mikuła-Pietrasik, J., Tykarski, A. et al. Sci Rep 15, 43,463 (2025). https://doi.org/10.1038/s41598-025-27414-x.
Cardiovascular risk factors can spark inflammation by eliciting misdirected responses of intrinsic vascular cells and leukocytes, culminating in lesion initiation, progression, and complication. Soehnlein and Libby review key underlying inflammatory mechanisms in atherosclerosis and discuss how new understanding based on increasingly sophisticated tools has enabled translation to the clinic.
Has a crucial component to the development of human medicine been hiding under our feet? Auburn University Assistant Professor of Entomology Clint Penick and a team of graduate students may have found that ants are far ahead of humans in antibiotic innovation. “In our study, we tested how ants use antibiotic compounds to fight off pathogens and asked why their chemical defenses remain effective over evolutionary time,” Penick said.
“Humans have relied on antibiotics for less than a century, yet many pathogens have already evolved resistance, giving rise to ‘superbugs.’ Ants, by contrast, have been using antibiotics for tens of millions of years, and they might hold the key to using these powerful drugs more wisely.”
Ants as a source of antibiotics The team looked at just six ant species, all found easily in the Southeastern United States.
In this work, Vigo et al. demonstrate that norepinephrine (NE) promotes myeloid hematopoiesis in BM and regulates thymic Tregs via B3ARs in EAE. B3ARs are controlled by hypothalamic AgRP neurons, which are dysfunctional in EAE. Serum levels of AgRP are elevated in people with MS and correlate with disease severity.