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Category: biotech/medical – Page 3,144

Capacitively coupled arrays of multiplexed flexible silicon transistors for long-term cardiac electrophysiology

Advanced capabilities in electrical recording are essential for the treatment of heart-rhythm diseases. The most advanced technologies use flexible integrated electronics; however, the penetration of biological fluids into the underlying electronics and any ensuing electrochemical reactions pose significant safety risks. Here, we show that an ultrathin, leakage-free, biocompatible dielectric layer can completely seal an underlying array of flexible electronics while allowing for electrophysiological measurements through capacitive coupling between tissue and the electronics, without the need for direct metal contact. The resulting current-leakage levels and operational lifetimes are, respectively, four orders of magnitude smaller and between two and three orders of magnitude longer than those of other flexible-electronics technologies. Systematic electro­physiological studies with normal, paced and arrhythmic conditions in Langendorff hearts highlight the capabilities of the capacitive-coupling approach. These advances provide realistic pathways towards the broad applicability of biocompatible, flexible electronic implants.

Senolytics against Aging: Snapshot of a Fast-Moving Field

A review of senescent cell removal therapies.

Aging at the cellular level is called “cell senescence”, and it contributes profoundly to whole-body aging. The most promising near-term prospects for a leap in human life expectancy come from drugs that eliminate senescent cells. Programs in universities and pharmaceutical labs around the world are racing to develop “senolytic” drugs, defined as agents that can kill senescent cells with minimal harm to normal cells.

Apoptosis is cell suicide, and (from the perspective of the full organism) it’s the best thing that can happen to senescent cells. The authors of this newest Dutch study ask how it is that senescent cells escape apoptosis.

FOXO is a protein that controls gene expression, a master transcription factor associated with aging and development. (It is the homolog in mammals of the pivotal life extension protein first identified in worms as DAF16 in the 1990s.) FOXO4 activiation in a cell can block apoptosis. P53 is the most common trigger of apoptosis, the first protein biochemists usually think of in connection with apoptosis. P53 has multiple functions in the cell nucleus, but as a trigger for apoptosis, it works through the mitochondria. FOXO4 binds to p53 and blocks its induction of apoptosis.

Robot Nannies Are Here, But Won’t Replace Your Babysitter — Yet

Robot nannies in Forbes today. Interesting story! https://www.forbes.com/sites/centurylink/2017/03/29/robot-na…e6632c56b7 #transhumanism

Would you let a robot care for your child?

As our population ages, these caregiver robots will also be useful for the old as well as the young.
As our population ages, these caregiver robots will also be useful for the old as well as the young.

This is not a rhetorical question. So-called robot nannies are already a hit in Japan and China, and are now beginning to appear stateside.

The numbers show why this is an attractive proposition. According to the U.S. Center for Disease Control and Prevention, approximately 4 million babies are born annually in the United States. That’s almost 11,000 daily births.

Nanotweezers to Handle DNA

Manipulating DNA with tweezers is now possible, using technology developed at a cutting-edge French-Japanese laboratory (LIMMS). The researchers designed silicon nanotweezers capable of grabbing and analyzing cells or molecular fibers. This microscopic instrument has already been used in Lille to test the resistance of DNA to irradiation.

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