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Fasting might boost intestinal stem cell function

A relatively easy way to boost intestinal stem cell (ISC) function might simply be fasting, according to a new study by a team of MIT biologists.


Stem cells supply the specialized cells that make up our tissues and organs; every time existing cells are lost for whatever reason, stem cells that can differentiate into that particular type of cell jump into action to compensate for the loss. However, this ability declines over time as aging progresses; indeed, stem cell exhaustion is one of the hallmarks of aging, and it affects our body by decreasing the regenerative capacity of its tissues, leading to immune dysfunction, muscle wasting, and even neurodegenerative diseases.

The lining of your intestine suffers from this problem as well. It consists of a fast-renewing tissue that typically renews itself entirely in a handful of days, and it is responsible for absorbing nutrients as well as keeping away unwanted substances; maintaining its regenerative abilities is therefore important for everyone, old or young; however, for older people, this is more challenging. However, a relatively easy way to boost intestinal stem cell (ISC) function might simply be fasting, according to a new study by a team of MIT biologists [1].

The study

The fact that caloric restriction yields health and longevity benefits in different kinds of organisms, possibly including humans, has already been known for a while. However, it is as of yet unclear what mechanisms cause this effect and to what extent people may benefit from it.

Yale experiment to reanimate dead brains promises ‘living hell’ for humans

A scientific experiment to reanimate dead brains could lead to humans enduring a ‘fate worse than death,’ an ethics lecturer has warned.

Last month Yale University announced it had successfully resurrected the brains of more than 100 slaughtered pigs and found that the cells were still healthy.

The reanimated brains were kept alive for up to 36 hours and scientists said the process, which should also work in primates, offered a new way to study intact organs in the lab.

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