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Category: biotech/medical – Page 304

New wearable device that mimics CT scans delivers continuous monitoring for heart and lung patients

Researchers have developed a first-of-its-kind wearable device capable of continuously scanning the lungs and heart of hospital patients while they rest in bed – offering a revolutionary alternative to CT scans.

The belt-like device, attached around a patient’s chest, uses ultrasound and works like a CT scanner. Rather than taking an isolated snapshot, it can produce a series of dynamic, high-resolution images of the heart, lungs and internal organs over time, giving doctors deeper insight into a patient’s condition. The device can be worn in bed and also reduces the need for repeated trips to radiology or exposure to doses of ionising radiation.

The breakthrough device has been developed at the University of Bath in collaboration with Polish technology company Netrix and is detailed in a recent publication in IEEE Transactions on Instrumentation and Measurement.

Groundbreaking sensor technology promises safer, real-time monitoring for hospitalised cardiothoracic patients.

Breakthrough by Shanghai doctors uses stem cells to cure diabetes

Doctors in Shanghai have, for the first time in the world, cured a patient’s diabetes through the transplantation of pancreatic cells derived from stem cells.

The 59-year-old man, who had Type 2 diabetes for 25 years, has been completely weaned off insulin for 33 months, Shanghai Changzheng Hospital announced on May 7.

A paper about the medical breakthrough, achieved after more than a decade of endeavor by a team of doctors at the hospital, was published on the website of the journal Cell Discovery on April 30.

It is the first reported instance in the world of a case of diabetes with severely impaired pancreatic islet function being cured via stem cell-derived autologous, regenerative islet transplantation, the hospital said. The most common pancreatic islet cells produce insulin.

(Circa 2024)

Exercise Improves Anticancer Immunity Through Gut Microbes

Exercise is extremely important, especially if we don’t move around much at work. There are plenty of apps and watches that can tell us when to move and be active. Primary care physicians emphasize exercise as a preventive measure against symptoms of aging. We are told that consistent exercise with a healthy diet is crucial for a high quality of life. As a result, we are all trying new diets and exercise routines to improve our health. Interestingly, there are specific regimens for individuals at different stages of life. Even cancer patients are encouraged to maintain as much of an active lifestyle as possible. However, how much does exercise really affect our health in cancer? Couldn’t we just each healthier?

A research group at the University of Pittsburgh discovered that exercise directly alters gut microbes which improve anticancer immunity. The paper published in Cell, by Dr. Marlies Meisel, Catherine Phelps, and others, demonstrated the mechanism that occurs in the gut after exercising. Meisel is an Assistant Professor in the Department of Immunology at the University at Pittsburgh. Catherine Phelps is a talented graduate student in the Meisel Lab and first author on the publication. Meisel’s research focuses on the mechanisms of the microbiota and its effect on systemic immunity. Specifically, she works to understand the role of the microbiome in the context of cancer and autoimmune disorders to improve therapeutic outcomes.

Previous work in the field demonstrated that exercise improves cancer therapy. Additionally, it was known that exercise changes the gut microbiome, which includes various bacteria that is helpful to the body. However, there was a gap missing between these two findings. Meisel and her team set out to understand how these two ideas were linked. Specifically, they wanted to know how exercise changes the gut microbiome to improve cancer immunotherapy. Catherine and other researchers in the Meisel Lab had mice exercise for four weeks in one group and had another group that did not exercise. When they implanted tumors, they found that the mice that exercised had smaller tumors compared to the no-exercise group. However, when researchers conducted the same experiment with mice that were germ-free or treated with antibiotics to eliminate the gut microbiome, they lost the change in tumor growth.

Tunable laser light: Ring design could be used in telecom, medicine and more

Researchers at the Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS) and Technical University of Vienna (TU Wien) have invented a new type of tunable semiconductor laser that combines the best attributes of today’s most advanced laser products, demonstrating smooth, reliable, wide-range wavelength tuning in a simple, chip-sized design.

Tunable lasers, or lasers whose light output wavelengths can be changed and controlled, are integral to many technologies, from high-speed telecommunications to medical diagnostics to safety inspections of gas pipelines.

Yet laser technology faces many trade-offs—for example, lasers that emit across a wide range of wavelengths, or colors, sacrifice the accuracy of each color. But lasers that can precisely tune to many colors get complicated and expensive because they commonly require moving parts.

Cutting-Edge Gene Therapy Restores Hearing Within Weeks

“This is a huge step forward in the genetic treatment of deafness, one that can be life-changing for children and adults,” says Maoli Duan, consultant and docent at the Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Sweden, and one of the study’s corresponding authors.

Gene therapy involved a synthetic adeno-associated virus (AAV) to deliver a functional version of the OTOF gene to the inner ear via a single injection through a membrane at the base of the cochlea called the round window. The injections were to target mutations in OTOF that can cause deficiencies of the otoferlin protein, that plays key roles in transmitting auditory signals.

According to the researchers, the effects of the gene therapy were rapid, and the majority of the participants recovered some hearing after one month. At a 6-month follow-up, all participants showed considerable improvements, with the average perceptible volume of sound improving from 106 decibels to 52 decibels.

Hiatus and pelvic floor failure patterns in pelvic organ prolapse: a 3D MRI study of structural interactions using a level III conceptual model

A large urogenital hiatus in level III results in a higher risk of developing pelvic organ prolapse after birth and failure after prolapse surgery. Deepening of the pelvic floor and downward rotation of the levator plate have also been linked to prolapse. Currently we lack data that evaluates how these measures relate to one another and to prolapse occurrence and size.

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