Toggle light / dark theme

The Neuroscientist Who’s Building a Better Memory for Humans

In an epidsode of the dystopian near-future series, Black Mirror, a small, implantable device behind the ear grants the ability to remember, access, and replay every moment of your life in perfect detail, like a movie right before your eyes.

Theodore Berger, a biomedical engineer at the University of Southern California, can’t promise that level of perfect recall—perhaps for the better—but he is working on a memory prosthesis. The device, surgically implanted directly into the brain, mimics the function of a structure called the hippocampus by electrically stimulating the brain in a particular way to form memories—at least in rats and monkeys. And now, he’s testing one that could work in humans.

Berger’s device hinges on a theory about how the hippocampus transforms short-term memories, like where you deposited your keys, into long-term memories—so you can find them later. In his early experiments, he played a tone and then puffed air in a rabbit’s face, causing it to blink. Eventually, just playing the tone would make the rabbit blink, just like Pavlov’s famous salivating dogs. Berger recorded the hippocampus’ activity with electrodes, and as the rabbits learned to associate the tone with the air puff, patterns in those signals changed in a predictable way.

Sydney high school students ‘show up’ Martin Shkreli, recreating price-hiked pill for $2

Last fall, the biotech executive Martin Shkreli became widely reviled for hiking the price of a life-saving drug by more than 4,000 percent overnight, to $750 per pill.

Public outrage at Shkreli has apparently reverberated all the way to a high school science lab in Australia, where a group of 11th grade students claim to have proven a point: the drug can be made for much, much cheaper.

The group of 11 high school students, ages 16 and 17, successfully recreated the drug, Daraprim, for a mere $2 a pill, according to scientists from the University of Sydney.

To fix its failing veteran healthcare system, the US Dept. of Veteran Affairs looks to AI

AI (someday once things are more secured) is going to drastically reduce our cost of government. At least the VA believes AI is going to make them better at treating folks; my guess it’s a mix of cost saving potential via automation and improving diagnosis.


Flow Health and the VA are building a medical knowledge graph with deep learning to inform medical decision-making and train AI to personalize care plans.

Transplanted Senescent Cells Induce an Osteoarthritis-Like Condition in Mice

Osteoarthritis and senescent cells the connection becomes a little clearer!


Another step closer to the link between senescent cells and Osteoarthritis. Here we see mice receiving transplanted senescent cells which induce a disease state similar to Osteoarthritis. Yet further confirmation that the SENS approach to removing senescent cells is beneficial.

“Osteoarthritis (OA) is the leading form of arthritis in the elderly, causing pain, disability, and immobility. OA has been associated with accumulation of senescent cells in or near joints. However, evidence for a causal link between OA and cellular senescence is lacking. Here, we present a novel senescent cell transplantation model involving injection of small numbers of senescent or nonsenescent cells from the ear cartilage of luciferase-expressing mice into the knee joint area of wild-type mice. By using bioluminescence and 18FDG PET imaging, we could track the injected cells in vivo for more than 10 days. Transplanting senescent cells into the knee region caused leg pain, impaired mobility, and radiographic and histological changes suggestive of OA. Transplanting nonsenescent cells had less of these effects. Thus, senescent cells can induce an OA-like state and targeting senescent cells could be a promising strategy for treating OA.”

Read more

Building “genetic circuits” in cells could kill tumors

More on the cell circuited technology that will deprive cancer cells of oxygen.


Imagine having cells in your body that can actively repel cancer in a way that makes it theoretically impossible for you to suffer from it.

Researchers at the U.K.’s University of Southampton…have engineered cells with a so-called “built-in genetic circuit” capable of producing a molecule for inhibiting the ability of tumors to grow and survive in the body.

“There are various defense mechanisms built into human cells, such as proteins that spot DNA damage, but there are also gaps in this defense system that are exploited by disease,” Professor Ali Tavassoli, one of the lead authors of the paper …“We were wondering if it is possible to equip human cells with the ability to sense and respond to a disease marker…”

Neuroscience Is a Tool of War

What could once only be imagined in science fiction is now increasingly coming to fruition: Drones can be flown by human brains’ thoughts. Pharmaceuticals can help soldiers forget traumatic experiences or produce feelings of trust to encourage confession in interrogation. DARPA-funded research is working on everything from implanting brain chips to “neural dust” in an effort to alleviate the effects of traumatic experience in war. Invisible microwave beams produced by military contractors and tested on U.S. prisoners can produce the sensation of burning at a distance.

What all these techniques and technologies have in common is that they’re recent neuroscientific breakthroughs propelled by military research within a broader context of rapid neuroscientific development, driven by massive government-funded projects in both America and the European Union. Even while much about the brain remains mysterious, this research has contributed to the rapid and startling development of neuroscientific technology.

And while we might marvel at these developments, it is also undeniably true that this state of affairs raises significant ethical questions. What is the proper role – if any – of neuroscience in national defense or war efforts? My research addresses these questions in the broader context of looking at how international relations, and specifically warfare, are shaped by scientific and medical expertise and technology.

Russia unveils CLONE DOGS that will work with Putin’s Special Forces

The CLONED dogs of war: Russia unveils genetically-enhanced canines which will work with Putin’s Special Forces and were created by scientist attempting to restore woolly mammoths

  • The three Belgian Malinois were cloned by a South Korean professor
  • He also aims to one day restore extinct woolly mammoths to Siberia
  • Dr Hwang Woo Suk gifted the dogs — each valued at $100,000 — to police
  • The will be used in Yakutia, the coldest inhabited region in the world

By Will Stewart In Moscow for MailOnline

Drugs to Extend Life — Nathaniel David, CEO of Unity Biotechnology

Nathaniel David from Unity Biotech giving a talk about the potential of Senolytics and how science can break the natural limit to lifespan. David is the CEO of Unity Biotechnology a company taking SENS based Senolytic drugs into human clinical trials in the next year or so. Very exciting as this is the first true rejuvenation biotechnology therapy to be deployed in humans.


Unity is leading the way for the first rejuvenation technologies in the #sens model. Here we have Nathaniel David from Unity talking about the potential of Senolytics and increased lifespans.

Unity Biotechnology is one of a number of companies developing Senolytic therapies to clear senescent cells from the body and they will no doubt be joined by them in the future a sure sign of the rising interestin the field.

There is however no doubt at this moment in time that Unity is leading the charge and with recent investment from Amazon’s Bezos and their movement into human clinicial trials within a year or so they are certainly the pioneers of this exciting new therapy.

#aging #crowdfundthecure

/* */