Lifeboat Foundation: Safeguarding Humanity
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Category: biotech/medical – Page 2,966

Engineer Robert Grass says that though we believe information is here forever, it’s actually fragile. Hard drives and physical sources of information, like books, decay over time. In a video for the BBC, Grass describes his quest to find a method of preserving information that could be stable for millions of years. The secret is DNA.

In 2012, research showed that you could translate a megabyte (MB) of information into DNA and then read it back again. DNA has a language of its own, and is written in sequences of nucleotides (A, C, T, and G). Think of it as similar to binary, which breaks information down into ones and zeros.

And DNA has the advantage of being able to put an enormous amount of information in a tiny space. Theoretically, one gram of DNA could hold 455 exabytes of information. That’s “enough for all the data held by Google, Facebook and every other major tech company, with room to spare”, according to New Scientist.

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Scientists have developed a way to produce soft, flexible and stretchy electronic circuits and radio antennas by hand, simply by writing on specially designed sheets of material.

This technique could help people draw electronic devices into existence on demand for customized devices, researchers said in a new study describing the method.

Whereas conventional electronics are stiff, new soft electronics are flexible and potentially stretchable and foldable. Researchers around the world are investigating soft electronics for applications such as wearable and implantable devices. [5 Crazy Technologies That Are Revolutionizing Biotech].

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Rollins, who has a Ph.D. in veterinary medicine, took some time to talk about genetic engineering, the future of humanity and the ethical limits of science.

(This Q&A has been edited for length and clarity.)

Live Science: A quote from “The Bone Labyrinth” reads, “Research today has become more about seeing if something can be done versus judging if it should. It’s knowledge for the sake of knowledge, regardless of the impact on the world.” Is that you speaking? Is that what you personally believe?

James Rollins: Yes, I believe that. I think sometimes, the reach of science is faster than its capacity to grasp. Genetic engineering is changing the world so fast right now. The CRISPR-Cas9 technique can allow us to pluck a single DNA unit out and replace it with great precision. And one of the people I interviewed in the research for this book told me that we now have the ability to do germline editing, where anyone with a basic biology degree and familiarity with embryos can alter an embryo pretty easily. And that’s something that’s relatively new. It’s just in the last five to 10 years that that’s been developed.

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3D printing in the medical industry isn’t new. We’ve seen companies 3D print prosthetics and even bones, but now a company in India has claimed to have developed 3D printable liver tissue, which they are hoping that one day will be usable for full-fledged liver transplants, although we suppose there will be quite a bit of legal and regulatory hurdles to overcome.

According to Pandorum Technologies, the company behind the technology, they claim that these 3D printed liver tissues are made of human cells and will allow for inexpensive medical research. This also means that reachers will need to rely less on human and animal trials. The entire process could also save companies millions of dollars which is usually needed in research and development.

Pandorum Technologies’ co-founder Arun Chandru said, “Our 3D bio-printed mini-livers that mimic the human liver will serve as test platforms for discovery and development of drugs with better efficacy, less side effects and at lower costs.” Apart from being used as test platforms, 3D printable liver tissue could also be used for other purposes.

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This came up recently and it occurred I never posted this here. This is a lecture by Robert Bradbury, not not Ray Bradbury. I had the pleasure of exchanging a few emails with him. Unfortunately those emails are lost so I cannot share them. He was an advocate of life extension and he was a big thinker. I’ll post both vids and a link to the M-brain page. He is not with us anymore I regret to say. Ready?

Renown aging expert Robert Bradbury discusses whole genome engineering, evolution and aging and ways to defeat aging. His talk touches on many areas including nanotechnology, biology, and computer science. More information can be found at http://manhattanbeachproject.com Follow updates at http://twitter.com/maxlifeorg

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Tardigrades — known affectionately as water bears or moss piglets — have pretty much got it all. These microscopic invertebrates are capable of surviving the most extreme conditions you could dream up, including prolonged desiccation and near-100 percent water loss, freezing and boiling temperatures, intense ionising radiation, and the vacuum of outer space.

Scientists have discovered that to survive extreme desiccation, tardigardes produce a special type of ‘bioglass’ to hold essential proteins and molecules together until they’re rehydrated back to life. Now they’re figuring out how to use this mechanism to develop drought-resistant crops and longer-lasting vaccines.

Back in September, researchers from the University of Chicago announced that they’d discovered a new type of glass — one produced internally by the tardigrade during desiccation. While they’re yet to figure out exactly how the glass is formed, they concluded that it’s produced as a protective mechanism to ensure that tardigrades can survive losing pretty much all of the water in their cells.

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If you haven’t heard of the bionic pancreas, it’s likely you soon will. With diabetes on the rise and the demand for insulin therapies becoming a real pain point for the medical establishment, the need for innovative solutions has spiked. Back in April, we reported on the Do-It-Yourself Pancreas system, a closed-loop artificial pancreas scavenged from a Medtronic pump, Dexcom CGM, a Raspberry Pi, and CareLink USB. Now a fully bionic pancreas similar in design to the Do-It-Yourself model is being developed by doctors at Massachusetts General Hospital and Boston University, with the goal of winning FDA approval. If it succeeds, this will likely be the first bionic organ to see widespread adoption.

Let’s examine some of the previous attempts at bionic organs to see if we can catch a glimpse of where things are heading and some of the societal repercussions that lay in wait. The holy grail of bionic organs is without question the human heart. Coronary artery disease being one of the principal causes of the death worldwide, a fully functioning bionic heart could radically change life expectancy and alter the demographic landscape.

The first bionic hearts, designed over 70 years ago, were plagued by problems that often resulted in thromboembolism and hemorrhage, and made this even more of a gamble than donor transplants. Recent technological advances, however — specifically the advent of bio-prosthetic materials that fool the human immune system into believing the bionic heart is an organic part of the body — could indicate a new era of artificial organs is upon us.

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Hydras, simple fresh-water animals, have the ability to live forever if kept in ideal conditions, a recent study shows.

The organisms are made mostly of stem cells that have the ability to continually divide, thus constantly renewing the body.

“The differentiated cells of the tentacles and the foot are constantly being pushed off the body and replaced with new cells migrating from the body column,” Daniel Martinez, a biologist at Pomona College, said in a statement.

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Death is a disease.

Diseases can and will be cured.

Do the math. wink

Disease GWAS show substantial genetic overlap with longevity. Shown are results for coronary artery disease and Alzheimer’s disease. The y axis is the observed P values for longevity, and the x axis is the expected P values under the null hypothesis that the disease is independent of longevity. The cyan, blue and purple lines show the P values for longevity of the top 100, 250, and 500 disease SNPs from independent genetic loci, respectively. Red lines show the background distribution of longevity P values for all independent genetic loci tested in both the longevity and disease GWAS. The grey horizontal line corresponds to the threshold for nominal significance (P = 0.05) for longevity. Significance of enrichment was determined with the hypergeometric test. (credit: Kristen Fortney et al./PLOS Genetics)

What’s the secret of centenarians who have health and diet habits similar to the average person but have remained active and alert at very old ages?

Genes. That’s according to scientists at Stanford University and the University of Bologna, who have written a new report published in PLOS Genetics, based on their finding of several disease variants that may be absent in centenarians compared to the general population.

Continue reading “New genes associated with extreme longevity identified” | >