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Category: biotech/medical – Page 2,895

Ava Winery’s first public taste test didn’t exactly go well. Two reporters on camera at New Scientist compared the biotech startup’s artificial wine with a glass of the Moscato D’Asti that it was based on. They complained that the fake wine had too little color, too little viscosity, and an unpleasant plastic smell.

But that was May, and this is September, and Ava is already bragging about making huge improvements in its product, to the point where it is all but indistinguishable from fermented grape juice, and looking ahead to how it’s going to change the world.

“What we have done since then is leaps and bounds beyond what they were able to taste back in May,” co-founder Alec Lee says. “Now we’re at the point where about 90% of people fail out blind taste test.”

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The Aubrey de Grey and Matthew O’Connor SENS AMA on reddit Monday 12th 11am PST.

I am Dr. Aubrey De Grey, biologist, gerontologist PhD and author of the book Ending Aging and Chief Science Officer at the SENS Research Foundation. I am here with researcher Dr. Matthew O’Connor from the MitoSENS project who is an expert on “allotopic expression” of mitochondrial genes. His team has been working on engineering mitochondrial genes to be expressed from the nucleus and targeted to the mitochondia as part of the MitoSENS approach to one of the damages of aging.

Each cell in the body is dependent on the efficient generation of cellular energy by mitochondria to stay alive. Critical to this process are genes encoded within the mitochondrial genome. Over time however, mutations in these genes occur as a result of constant exposure to reactive oxygen species produced by oxidative phosphorylation, the mitochondrial energy generation process. Unlike genes within the nucleus, mitochondria lack an efficient system to repair damaged DNA. This leads to accumulated mutations, resulting in mitochondrial defects and an increase in oxidative stress throughout the body. Closely correlated with this is the observation that organisms which age more slowly also consistently display lower rates of mitochondrial free radical damage. Thus, reversing and/or preventing damage to mitochondrial DNA may be a key factor in slowing the aging process.

The SENS Research Foundation recently published very positive data the result of a community fundraiser at Lifespan.io showing that the MitoSENS approach is viable. If you would like to read our published paper you can do so here.

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DNA, our genetic material, normally has the structure of a twisted rope ladder. Experts call this structure a double helix. Among other things, it is stabilized by stacking forces between base pairs. Scientists at the Technical University of Munich (TUM) have succeeded at measuring these forces for the very first time on the level of single base pairs. This new knowledge could help to construct precise molecular machines out of DNA. The researchers published their findings in the journal Science.

Over 60 years ago, the researchers Crick and Watson identified the structure of deoxyribonucleic acid, which is more commonly known as DNA. They compared the double helix to a rope ladder that had been twisted into a spiral. The rungs of this ladder consisted of guanine/cytosine and thymine/adenine . But what keeps the DNA strands in that spiral structure?

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“Geomagic Control X is by far the most intuitive and powerful inspection software we have ever used,” said James Earl, Managing Director, OR3D. “We are excited for the improvements this software will bring to our customers.”

This software update is available to all active customers of 3D Systems’ Maintenance Program.

About 3D Systems 3D Systems provides comprehensive 3D products and services, including 3D printers, print materials, on-demand manufacturing services and digital design tools. Its ecosystem supports advanced applications from the product design shop to the factory floor to the operating room. 3D Systems’ precision healthcare capabilities include simulation, Virtual Surgical Planning, and printing of medical and dental devices as well as patient-specific surgical instruments. As the originator of 3D printing and a shaper of future 3D solutions, 3D Systems has spent its 30 year history enabling professionals and companies to optimize their designs, transform their workflows, bring innovative products to market and drive new business models.

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Recent plans to use these techniques to obstruct mosquitoes’ disease-carrying abilities have raised concerns from both experts and the public, and some have even argued that the tool can be used to create biological weapons.

Now, the US Defense Advanced Research Projects Agency has revealed a new program that aims to set a ‘safe course’ for this field, with hopes that their toolkit can work both to support bio-innovation and combat bio-threats.

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Written by ROLAND BENEDIKTER, KATJA SIEPMANN, ALEXANDER REYMANN

ABSTRACT. This article discusses the philosophical implications and potential social consequences of two experimental – and at the present moment still widely speculative – topics at the intersection between scientific and medical advances, the human body, the human mind, and the globalized health care sector. Head-Transplanting is a chirurgical endeavor envisaged by the HEAVEN project announced to be practically implemented around 2017 and to be available for routine-use around the mid-2020s by a group of internationally as prominent as disputed transplant surgeons. Mind-Uploading is a procedure currently in the first stages of development to create artificial representations of the human brain and its processes in computers and on the internet.

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I cannot wait to see how we can use VR for obtaining additional insights on other central nervous system diseases and disorders such as MS, Dystonia, GBM, etc.

Medical applications for VR continue to spread. Just a few weeks ago I wrote about how Paraplegics can learn to walk again with help from Virtual Reality. Scientists from Tomsk Polytechnic University and the Siberian State Medical University, in Russia, believe that it could be the future of diagnosing neurodegenerative diseases such as multiple sclerosis and Parkinson’s disease.

Methods to diagnosis many of these conditions is accomplished by visual assessment in most parts of Russia. The brain scanning technology such as a CAT scan or MRI to confirm the diagnosis is only available in a handful of cities. The VR system being developed would be cheap and easy to roll out across the country.

Virtual Reality Balance Test.

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NICE.

Scientists at the Swiss Nanoscience Institute, the University of Basel, and the University Hospital Basel have developed and have been testing a device that can screen people with malignant melanoma for a spcific genetic mutation. About half of malignant melanoma cases involve the BRAF gene that results in rapid cell division and drugs targeting this type of cancer are available. The problem is that without knowing if a patient exhibits the mutation, it is dangerous to prescribe the medications since they will not work and will only cause additional problems.

The new device was used to analyze malignant melanoma tissue samples and to find whether the relevant genetic sequence is present. It relies on microscopic cantilevers, some of which have a coating to which the particular genetic sequence sticks to. Other cantilevers have a coating without the sequence. RNA isolated from the biopsy samples was then introduced into the device and the molecules that stuck to the cantilevers made them bend. This bending can be detected, pointing to the presence of the searched for mutation.

The whole process, from when the biopsy is taken to when the result is produced, can be done within a day and appropriate therapy administered right after.

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