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Every day in a San Diego lab, raw material derived from donated tissue unsuitable for organ transplantation goes into a machine, and three-dimensional human liver tissue is printed out.

Pioneered by a company called Organovo, this 3D bioprinting technology may one day achieve the Holy Grail of its industry: the manufacturing of whole human organs to replace damaged ones. But for now, it’s already making an impact on human health, as pharmaceutical and biotech companies are using its manufactured human liver tissue to test the toxicity of new drugs and therapies.

Organovo is developing multiple tissue types for therapeutic use, with strong early results in animal models. In three to five years, there’s a good chance that it will have an Investigational New Drug Application in at least one tissue. The company’s strategic plan is coming to fruition just as its chief scientific officer, Sharon Presnell, envisioned when she joined the startup in 2011.

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I did a long-form interview on Medium’s Defiant of my run for California Governor. It covers many subjects (Trump, gene editing, basic income), as well as why I think technology is ready to change politics and governance forever:


By AJAI RAJ

Stop me if you’ve heard this one before. It’s 2015, and the ever-humming machinery of American presidential politics is picking up steam. The American political machine runs on steam, okay? It’s very old.

Out of the predictable, claustrophobic sameness of the political duopoly — with naked oligarchy on one side and an ostensibly friendlier, more diverse oligarchy on the other — emerges a candidate with some new ideas. Oh, maybe not completely new ideas, but wild ideas, fresh ideas, ideas long thought to be unpalatable to the American political mainstream.

Ideas like free college for everybody, a universal basic income, or UBI … and abolishing death once and for all.

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As I start to look at the emerging trends of 2017 from the vantage of IndieBio, where we see hundreds of biotech startup applications and technologies per year, a few key themes are already emerging. Even as political landscapes change, science and technology continue to push forward.

1. Cell Therapies and Regenerative Medicine

Most of us have seen science fiction shows that show future doctors regrowing and replacing entire organs. That fiction is now becoming a reality with cell therapies from companies like Juno (curing two infants with leukemia of their previously treatment resistant cancers with engineered T-cells), induced pluripotent stem cells (iPS) pioneered by the Nobel prize winning scientist, Shinya Yamanaka that can become any cell in the body, growing organoids (mini organs with some function of a fully grown organ like the stomach organoids grown by researchers in Ohio), and entirely re-grown organs.

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By Matt Reynolds

By making DNA endlessly change, researchers have shown how a biological computer might one day solve problems much faster than conventional computers or even quantum computers. It’s still a long way from being functional though.

The DNA-based system is an experiment in how it may be possible to make a theoretical type of computer known as a non-deterministic universal Turing machine.

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The goal of transcending flesh is an old fetish. Yogis meditated and fasted for eons in order to rise above our ‘meat casing,’ performing painful ablutions and inventing kriyas, intense breathing exercises that are physiologically indistinct from intentional hyperventilation. The goal of many religions, from some forms of Tibetan Buddhism to numerous strains of Christianity and Islam, is all about letting the spirit soar free.

While language changes, pretensions remain. Today we talk about ‘uploading consciousness’ to an as of yet discovered virtual cloud. Artificial intelligence is only moments away, so the story goes, with experts weighing in on the ethical consequences of creating machines void of emotional response systems. In this view consciousness, itself a loaded and mismanaged term, is nothing more than an algorithm waiting to be deciphered. Upon cracking the code, immortality awaits.

Of course others are more grounded. The goal of extending life to 150 years includes the body by default, though the mind is still championed above all else. Yet we seem to age in opposing directions by design. At forty-one little has changed in how I think about myself, yet my body is decaying: a post-knee surgery creek here, a perpetual tight shoulder there. It certainly feels like a slowly approaching transition, even if that, like much of life, is an illusion.

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What makes a cluster of cells become a liver, or a muscle? How do our genes give rise to proteins, proteins to cells, and cells to tissues and organs?

The incredible complexity of how these biological systems interact boggles the mind—and drives the work of biomedical scientists around the world.

But a pair of mathematicians has introduced a new way of thinking about these concepts that may help set the stage for better understanding of our bodies and other living things.

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The new research, led by nanoengineering professor Shaochen Chen, addresses one of the biggest challenges in tissue engineering: creating lifelike tissues and organs with functioning vasculature — networks of blood vessels that can transport blood, nutrients, waste and other biological materials — and do so safely when implanted inside the body.

Researchers from other labs have used different 3D printing technologies to create artificial blood vessels. But existing technologies are slow, costly and mainly produce simple structures, such as a single blood vessel — a tube, basically. These blood vessels also are not capable of integrating with the body’s own vascular system.

“Almost all tissues and organs need blood vessels to survive and work properly. This is a big bottleneck in making organ transplants, which are in high demand but in short supply,” said Chen, who leads the Nanobiomaterials, Bioprinting, and Tissue Engineering Lab at UC San Diego. “3D bioprinting organs can help bridge this gap, and our lab has taken a big step toward that goal.”

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Austen Heinz was Founder and CEO of Cambrian Genomics. With his company, Austen hoped to change the world by democratizing access to DNA through cost-effective and fast DNA laser printing. Austen will always be remembered as one of the most passionate, creative people to have spoken at Draper University.

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