And it begins.
Judge Deborah Katz, a former scientist, is presiding over the case of who holds the key intellectual property rights for CRISPR.
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Category: biotech/medical – Page 2748
African trypanosomiasis is called ‘sleeping sickness’ because when the infection is untreated, trypanosome parasites will invade the brain and cause disruption of sleeping patterns and irreversible neurological damage. A study published on February 25th in PLOS Pathogens reports that in a mouse model of trypanosome disease, nitric oxide (NO) plays an unexpected role in preserving the integrity of the blood brain barrier (BBB), thereby reducing parasite invasion into the brain, and likely limiting neurological damage.
NO is generally thought to be a pro-inflammatory signal, promoting a strong immune response against pathogens. The resulting inflammation is a mixed blessing: on one hand, it helps to control potentially dangerous pathogens, but on the other, it can cause “collateral damage” to the inflamed tissue.
Martin Rottenberg and colleagues, from the Karolinska Institute in Stockholm, Sweden, are interested in how trypanosome parasites cause disease and in the host immune defense against them. In this study, they examine the role of NO in a mouse model of trypanosomiasis, with a focus on how the parasites manage to get through the so-called blood brain barrier (BBB), the border surrounding the mammalian brain that is normally impenetrable to foreign intruders as well as most host cells.
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Just Amazing
Ralph Mobbs, a neurosurgeon at the Prince of Wales Hospital in Sydney, made medical history in late 2015 when he successfully replaced two vertebrae with custom made prosthesis. The patient, in his 60s, suffered from Chordoma, a particularly nasty form of cancer that had formed on his top two vertebrae and threatened to cinch off his spinal cord as it grew. That would have left him a quadriplegic. Complicating matters, those top two vertebrae are what allow you to turn and tilt your head, so it’s not like doctors can easily fashion a replacement out of bone grafted from another part of the patient’s body. They have to fit perfectly and that’s where the 3D printers come in.
Mobbs worked with Anatomics, an Australian medical device manufacturer, to craft perfect replicas of the patient’s top two vertebrae out of titanium. This is the first time that these two particular neck bones have been printed and installed. “To be able to get the printed implant that you know will fit perfectly because you’ve already done the operation on a model … It was just a pure delight,” Mobbs told Mashable Australia. “It was as if someone had switched on a light and said ‘crikey, if this isn’t the future, well then I don’t know what is’.”
The surgery itself was no small feat. The 15-hour procedure is fraught with peril as the medical team operates within inches of the top of the spinal cord as well as the brainstem and numerous major arteries. “The surgery that we’re doing today is a particularly complicated and long and difficult surgery. It involves exposure at the top of the neck where the neck and the head meets,” Mobbs told ABC 7.30. “It’s essentially disattaching the patient’s head from his neck and taking the tumour out and reattaching his head back onto his neck.” Thankfully, the surgery was a success. Mobbs was able to remove the tumor and implant the prosthetic.
Using a sophisticated, custom-designed 3D printer, regenerative medicine scientists at Wake Forest Baptist Medical Center have proved that it is feasible to print living tissue structures to replace injured or diseased tissue in patients.
Reporting in Nature Biotechnology, the scientists said they printed ear, bone and muscle structures. When implanted in animals, the structures matured into functional tissue and developed a system of blood vessels. Most importantly, these early results indicate that the structures have the right size, strength and function for use in humans.
“This novel tissue and organ printer is an important advance in our quest to make replacement tissue for patients,” said Anthony Atala, M.D., director of the Wake Forest Institute for Regenerative Medicine (WFIRM) and senior author on the study. “It can fabricate stable, human-scale tissue of any shape. With further development, this technology could potentially be used to print living tissue and organ structures for surgical implantation.”
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What happens when a patient is in X-Ray and the X-Ray machine blows up like a bomb killing the patient and staff in the room? Well, a new report shows that it can happen where machines are connected to any network (including the net) because a team of hackers showed in their report how they were they hacked several D.C. and Maryland Hospitals medical devices and numerous machines including life support, X-Rays, etc.
Area hospitals are riddled with cybersecurity flaws that could allow attackers to hack into medical devices and kill patients, a team of Baltimore-based researchers has concluded after a two-year investigation.
Hackers at Independent Security Evaluators say they broke into one hospital’s systems remotely to take control of several patient monitors, which would let an attacker disable alarms or display false information.
The team says it strolled into one hospital’s lobby and used an easily accessible kiosk to commandeer computer systems that track medicine delivery and bloodwork requests — more opportunities for malicious hackers to create mayhem.
