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Hallmarks of Aging – Altered Intercellular Communication

Today, we conclude our ongoing series discussing the Hallmarks of Aging [1] by looking at the hallmark of altered intercellular communication, the change in signals between cells that can lead to some of the diseases and disabilities of aging.

As an integrative hallmark, altered intercellular communication is caused by other hallmarks of aging. As a result, there is some hope that therapies targeting these other hallmarks will be able to treat this one.

There are a wide range of complex intercellular communications associated with aging, but we will focus on the ones discussed in the Hallmarks of Aging paper.

New Pill can Deliver Insulin Through the Stomach

An MIT-led research team has developed a drug capsule that could be used to deliver oral doses of insulin, potentially replacing the injections that people with type 2 diabetes have to give themselves every day.

About the size of a blueberry, the capsule contains a small needle made of compressed insulin, which is injected after the capsule reaches the stomach. In tests in animals, the researchers showed that they could deliver enough insulin to lower blood sugar to levels comparable to those produced by injections given through skin. They also demonstrated that the device can be adapted to deliver other protein drugs.

“We are really hopeful that this new type of capsule could someday help diabetic patients and perhaps anyone who requires therapies that can now only be given by injection or infusion,” says Robert Langer, the David H. Koch Institute Professor, a member of MIT’s Koch Institute for Integrative Cancer Research, and one of the senior authors of the study.

Want to live forever? You just have to make it to 2050

“If you’re under 40 reading this article, you’re probably not going to die unless you get a nasty disease.”

Those are the words of esteemed futurologist Dr. Ian Pearson, who told The Sun he believes humans are very close to achieving “immortality” – the ability to never die.

Humans have been trying to find a way to dodge death for years.

Data Driven Investor

How competing software, hardware and political ideology could accelerate existing divisions in humanity into the future

It’s been great to get people’s thoughts and feedback on the last article on “The iPhone 20”. Some of your responses considered that given Apple’s business model is effectively a walled garden, this makes any integration with the human body very unlikely in the future.

That’s why in this article, rather than focusing on Apple, I’ll look to explore some of the ways tech companies and organisations (including government bodies) will compete on software, hardware and protocols that will shape humanity’s journey to 2029, which may accelerate our existing divisions that stifle collaboration and splinters our future societies.

Cesarean Section — A Brief History

While Barry applied Western surgical techniques, nineteenth-century travelers in Africa reported instances of indigenous people successfully carrying out the procedure with their own medical practices. In 1879, for example, one British traveller, R.W. Felkin, witnessed cesarean section performed by Ugandans. The healer used banana wine to semi-intoxicate the woman and to cleanse his hands and her abdomen prior to surgery. He used a midline incision and applied cautery to minimize hemorrhaging. He massaged the uterus to make it contract but did not suture it; the abdominal wound was pinned with iron needles and dressed with a paste prepared from roots. The patient recovered well, and Felkin concluded that this technique was well-developed and had clearly been employed for a long time. Similar reports come from Rwanda, where botanical preparations were also used to anesthetize the patient and promote wound healing.


In Western society women for the most part were barred from carrying out cesarean sections until the late nineteenth century, because they were largely denied admission to medical schools. The first recorded successful cesarean in the British Empire, however, was conducted by a woman. Sometime between 1815 and 1821, James Miranda Stuart Barry performed the operation while masquerading as a man and serving as a physician to the British army in South Africa.

A naked, pregnant woman lies on an angled bed inside a building. Three naked men attend her childbirth. The man on the left stands holding her belly on both sides with his hands. The man in the center is on the opposite side of the bed, with his left hand on her right hip and the right hand upraised holding a knife. The man on the right is crouching at the woman's feet holding them down with both hands.

Successful Cesarean section performed by indigenous healers in Kahura, Uganda. As observed by R. W. Felkin in 1879 from his article “Notes on Labour in Central Africa” published in the Edinburgh Medical Journal, volume 20, April 1884, pages 922–930.

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