Aug 15, 2016
Anti-inflammatory drug reverses memory loss in Alzheimer’s-disease-model mice
Posted by Sean Brazell in categories: bioengineering, biotech/medical, genetics, life extension, neuroscience
Anti-inflammatory drug mefenamic acid completely reversed memory loss and brain inflammation in mice genetically engineered to develop symptoms of Alzheimer’s disease and amyloid beta-induced memory loss, a team led by David Brough, PhD, from the University of Manchester has discovered.
The non-steroidal anti-inflammatory drug (NSAID) drug targets an important inflammatory pathway called the NLRP3 inflammasome, which damages brain cells, according to Brough. This is the first time a drug has been shown to target this inflammatory pathway, highlighting its importance in the disease model, Brough said.
Continue reading “Anti-inflammatory drug reverses memory loss in Alzheimer’s-disease-model mice” »