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Category: biotech/medical – Page 2,521
New drug raises hopes of reversing memory loss in old age
An experimental drug that bolsters ailing brain cells has raised hopes of a treatment for memory loss, poor decision making and other mental impairments that often strike in old age.
The drug could be taken as a daily pill by over-55s if clinical trials, which are expected to start within two years, show that the medicine is safe and effective at preventing memory lapses.
Tests in the lab showed that old animals had far better memory skills half an hour after receiving the drug. After two months on the treatment, brain cells which had shrunk in the animals had grown back, scientists found.
Anti-Aging Drug That Kills Old Cells Passes First Human Trial
Over the course of three weeks, the patients took nine doses of a leukemia drug called dasatinib and quercetin, a supplement. By the end of the trial, the patients were reportedly able to walk farther than they could previously in the same amount of time and other signs of improved well being — all without any serious side effects.
“Though small, this pilot study marks a major breakthrough in how we treat age-related diseases such as IPF,” researcher Jamie Justice said in a press release. “Here, we’ve therapeutically targeted a fundamental biological hallmark of aging that is implicated in IPF, and we show early but promising results for the first time in human patients.”
Ending Aging. Be Excited!
Be excited! Technology is rapidly advancing to eliminate age related sickness and death.
Imagine a world where aging will be reversed and people can remain young and in good health. Dr. Aubrey de Gray and others are working on therapies in making this a reality.
Aging is a disease and they are working on the cure.
If a 60 year old takes these damage repair therapies, they become biologically 30 years old again and in good health.
Old age and death are a thing of the past.
Let your thoughts and prayers be with Aubrey and the scientists working on longevity research. Know that they will be successful. Age reversal and damage repair therapies will be available for the public to use within 20 years. Technology is rapidly advancing.
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Lactate triggers genes that modify brain activity
A genome-wide study led by Dean Pierre Magistretti sheds light on the mechanisms through which lactate regulates long-term memory formation and neuroprotection.
The breakdown of sugar in non-neuronal brain cells, called astrocytes, produces lactate, which gets shuttled to neurons as a source of energy. This lactate not only supports the energy demands of neurons, but also rapidly and transiently activates multiple genes that modulate neuronal activity and regulate brain function.
Previous studies have shown that lactate stimulates the expression of genes encoding proteins involved in neuronal activity by signaling through N-methyl-D-aspartate (NMDA) receptors. Magistretti’s latest study reveals the extent to which lactate modifies gene expression in cortical neurons and also points to the mechanisms through which lactate modulates brain function.
Pregnant Women Are Being Targeted by Antivax Ads Online During a Measles Outbreak
Facebook is aggressively being used by anti-vaccination advocates to target pregnant women with sponsored advertisements to spread false information and conspiracy theories as the US battles a climbing measles outbreak.
A sponsored ad found by Quartz journalist Jeremy Merrill shows the anti-vaccination organisation Stop Mandatory Vaccination targeting women ages 20 to 60 who have expressed interest in pregnancy living in the state of Washington – where the governor recently declared a state of emergency over the measles outbreak.
Nearly 50 children and young adults in Clark County, Washington have become sickened by the disease since January.